Search Results - "Davidoff, A. M."

MicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcome by Ryan, J, Tivnan, A, Fay, J, Bryan, K, Meehan, M, Creevey, L, Lynch, J, Bray, I M, O'Meara, A, Davidoff, A M, Stallings, R L

“…Background: Neuroblastoma remains a major cause of cancer-linked mortality in children. miR-204 has been used in microRNA expression signatures predictive of…”
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Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine by McIntosh, J H, Cochrane, M, Cobbold, S, Waldmann, H, Nathwani, S A, Davidoff, A M, Nathwani, A C

“…The ability of transient immunosuppression with a combination of a non-depleting anti-CD4 (NDCD4) antibody and cyclosporine (CyA) to abrogate immune reactivity…”
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Timing of adjuvant chemotherapy after laparotomy for Wilms tumor and neuroblastoma by Ross, A., Gomez, O., Wang, X., Lu, Z., Abdelhafeez, H., Davidoff, A. M., Talbot, L., Murphy, A. J.

“…Purpose To describe the timing of chemotherapy initiation after surgery for Wilms tumor (WT) and neuroblastoma within a dedicated children’s cancer center…”
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Enhancing transduction of the liver by adeno-associated viral vectors by Nathwani, A C, Cochrane, M, McIntosh, J, Ng, C Y C, Zhou, J, Gray, J T, Davidoff, A M

“…A number of distinct factors acting at different stages of the adeno-associated virus vector (AAV)-mediated gene transfer process were found to influence…”
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Long-term outcomes of pediatric and adolescent mediastinal germ cell tumors: a single pediatric oncology institutional experience by Grabski, D. F., Pappo, A. S., Krasin, M. J., Davidoff, A. M., Rao, B. N., Fernandez-Pineda, I.

“…Purpose To evaluate the epidemiologic, demographic, and clinical characteristics, as well as prognostic factors and long-term outcomes of mediastinal germ cell…”
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Long-term functional outcomes and quality of life in adult survivors of childhood extremity sarcomas: a report from the St. Jude Lifetime Cohort Study by Fernandez-Pineda, Israel, Hudson, M. M., Pappo, A. S., Bishop, M. W., Klosky, J. L., Brinkman, T. M., Srivastava, D. K., Neel, M. D., Rao, B. N., Davidoff, A. M., Krull, K. R., Mulrooney, D. A., Robison, L. L., Ness, K. K.

“…Purpose This study compared measured physical performance, health-related quality of life (HRQOL), and social role attainment between extremity sarcoma…”
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Outcomes of a pediatric surgical oncology fellowship in a pediatric cancer institution by Fernandez‐Pineda, I., Sanders, D., Rao, B.N., Shochat, S.J., Davidoff, A.M.

“…Surgery plays an important role as part of the treatment plan in most children with malignant solid tumors in regards to initial biopsy, upfront resection, and…”
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Maturation of Tumor Vasculature by Interferon-β Disrupts the Vascular Niche of Glioma Stem Cells by WILLIAMS, R. F, SIMS, T. L, TRACEY, L, MYERS, A. L, NG, C. Y. C, POPPLETON, H, NATHWANI, A. C, DAVIDOFF, A. M

“…The vascular niche necessary for cancer stem cell maintenance is a potential target for cancer therapy. Human glioma xenografts were treated with IFN-β…”
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Bone Marrow-derived Cells Contribute to Tumor Neovasculature and, When Modified to Express an Angiogenesis Inhibitor, Can Restrict Tumor Growth in Mice by DAVIDOFF, Andrew M, NG, Catherine Y. C, BROWN, Peggy, LEARY, Margaret A, SPURBECK, William W, ZHOU, Junfang, HORWITZ, Edwin, VANIN, Elio F, NIENHUIS, Arthur W

“…Inhibition of tumor-induced neovascularization appears to be an effective anticancer approach, although long-term angiogenesis inhibition may be required. An…”
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Immune Response to p53 is Dependent Upon p53/HSP70 Complexes in Breast Cancers by Davidoff, Andrew M., Iglehart, J. Dirk, Marks, Jeffrey R.

“…Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in >25% of primary human breast cancers. In…”
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NF-κB activation mediates resistance to IFNβ in MLL-rearranged acute lymphoblastic leukemia by Tracey, L, Streck, C J, Du, Z, Williams, R F, Pfeffer, L M, Nathwani, A C, Davidoff, A M

“…Acute lymphoblastic leukemia (ALL) harboring the t(4;11) translocation is associated with a very poor prognosis; innovative treatment strategies are required…”
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Overexpression and mutation of p53 in epithelial ovarian cancer by MARKS, J. R, DAVIDOFF, A. M, KERNS, B. J, HUMPHREY, P. A, PENCE, J. C, DODGE, R. K, CLARKE-PEARSON, D. L, IGLEHART, J. D, BAST, R. C, BERCHUCK, A

“…We examined p53 expression in 107 epithelial ovarian cancers with immunohistochemical techniques using monoclonal antibody PAb1801. High level expression of…”
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Genetic Basis for p53 Overexpression in Human Breast Cancer by Davidoff, Andrew M., Humphrey, Peter A., Iglehart, J. Dirk, Marks, Jeffrey R.

“…Overexpression of an activated form of the p53 protein may be involved in neoplastic transformation. We found widespread overexpression of p53 by…”
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Antitumor efficacy of AAV-mediated systemic delivery of interferon-beta by Streck, C J, Dickson, P V, Ng, C Y C, Zhou, J, Hall, M M, Gray, J T, Nathwani, A C, Davidoff, A M

“…Type I interferons (alpha/beta) have significant antitumor activity although their short half-life and systemic side effects have limited their clinical…”
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Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer by Kohler, M F, Marks, J R, Wiseman, R W, Jacobs, I J, Davidoff, A M, Clarke-Pearson, D L, Soper, J T, Bast, Jr, R C, Berchuck, A

“…The p53 gene encodes a nuclear phosphoprotein present in low levels in normal human cells. The wild-type form of this protein functions to restrain…”
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Prospects for gene therapy of haemophilia by Nathwani, A. C., Davidoff, A. M., Tuddenham, E. G. D.

“…That gene therapy offers the promise of a cure for haemophilia was apparent more than a decade ago. After years of failure, substantial progress in the…”
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Is reexcision in pediatric nonrhabdomyosarcoma soft tissue sarcoma necessary after an initial unplanned resection? by Chui, C.H., Spunt, S.L., Liu, T., Pappo, A.S., Davidoff, A.M., Rao, B.N., Shochat, S.J.

“…Purpose: The aim of this study was to determine the importance of pretreatment reexcision (PRE) of pediatric nonrhabdomyosarcoma soft tissue sarcoma (NRSTS)…”
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Mechanisms of major biliary injury during laparoscopic cholecystectomy by DAVIDOFF, A. M, PAPPAS, T. N, MURRAY, E. A, HILLEREN, D. J, JOHNSON, R. D, BAKER, M. E, NEWMAN, G. E, COTTON, P. B, MEYERS, W. C

“…Laparoscopic cholecystectomy has become the procedure of choice for surgical removal of the gallbladder. The most significant complication of this new…”
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Current status and prospects for gene therapy by Nathwani, A. C., Benjamin, R., Nienhuis, A. W., Davidoff, A. M.

“…Gene therapy is a new and exciting therapeutic concept that offers the promise of cure for an array of inherited, malignant and infectious disorders. After…”
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Gene therapy-mediated expression by tumor cells of the angiogenesis inhibitor flk-1 results in inhibition of neuroblastoma growth in vivo by Davidoff, A.M., Leary, M.A., Ng, C.Y.C., Vanin, E.F.

“…Preventing tumors from forming new blood vessels appears to be an effective new anticancer approach. Antiangiogenic therapy usually is cytostatic, however,…”
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