Search Results - "David S. Williams"

A comparison of some organizational characteristics of the mouse central retina and the human macula by Volland, Stefanie, Esteve-Rudd, Julian, Hoo, Juyea, Yee, Claudine, Williams, David S

“…Mouse models have greatly assisted our understanding of retinal degenerations. However, the mouse retina does not have a macula, leading to the question of…”
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The cell biology of the retinal pigment epithelium by Lakkaraju, Aparna, Umapathy, Ankita, Tan, Li Xuan, Daniele, Lauren, Philp, Nancy J., Boesze-Battaglia, Kathleen, Williams, David S.

“…The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the…”
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Hierarchical Self-Assembly of a Copolymer-Stabilized Coacervate Protocell by Mason, Alexander F, Buddingh’, Bastiaan C, Williams, David S, van Hest, Jan C. M

“…Complex coacervate microdroplets are finding increased utility in synthetic cell applications due to their cytomimetic properties. However, their intrinsic…”
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Molecular basis for photoreceptor outer segment architecture by Goldberg, Andrew F.X., Moritz, Orson L., Williams, David S.

“…To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the light stimuli into cellular signals, and then convey the encoded…”
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Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy by Cao, Shoupeng, Shao, Jingxin, Wu, Hanglong, Song, Shidong, De Martino, Maria Teresa, Pijpers, Imke A. B., Friedrich, Heiner, Abdelmohsen, Loai K. E. A., Williams, David S., van Hest, Jan C. M.

“…Aggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly…”
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Tuning the membrane permeability of polymersome nanoreactors developed by aqueous emulsion polymerization-induced self-assembly by Varlas, Spyridon, Foster, Jeffrey C, Georgiou, Panagiotis G, Keogh, Robert, Husband, Jonathan T, Williams, David S, O'Reilly, Rachel K

“…Polymeric vesicles (or polymersomes) are hollow bilayer structures consisting of an inner aqueous compartment enclosed by a hydrophobic membrane. Vesicular…”
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Photoactivated Polymersome Nanomotors: Traversing Biological Barriers by Shao, Jingxin, Cao, Shoupeng, Williams, David S., Abdelmohsen, Loai K. E. A., Hest, Jan C. M.

“…Synthetic nanomotors are appealing delivery vehicles for the dynamic transport of functional cargo. Their translation toward biological applications is limited…”
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Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide by Hazim, Roni A., Volland, Stefanie, Yen, Alice, Burgess, Barry L., Williams, David S.

“…Human RPE cell lines, especially the ARPE-19 cell line, are widely-used in eye research, as well as general epithelial cell studies. In comparison with primary…”
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Spatial Organization in Proteinaceous Membrane‐Stabilized Coacervate Protocells by Li, Junbo, Liu, Xiaoman, Abdelmohsen, Loai K. E. A., Williams, David S., Huang, Xin

“…As a model protocell, the membrane‐free coacervate microdroplet is widely utilized in functional studies to provide insights into the physicochemical…”
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ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption by Ashraf, Shazia, Gee, Heon Yung, Woerner, Stephanie, Xie, Letian X, Vega-Warner, Virginia, Lovric, Svjetlana, Fang, Humphrey, Song, Xuewen, Cattran, Daniel C, Avila-Casado, Carmen, Paterson, Andrew D, Nitschké, Patrick, Bole-Feysot, Christine, Cochat, Pierre, Esteve-Rudd, Julian, Haberberger, Birgit, Allen, Susan J, Zhou, Weibin, Airik, Rannar, Otto, Edgar A, Barua, Moumita, Al-Hamed, Mohamed H, Kari, Jameela A, Evans, Jonathan, Bierzynska, Agnieszka, Saleem, Moin A, Böckenhauer, Detlef, Kleta, Robert, El Desoky, Sherif, Hacihamdioglu, Duygu O, Gok, Faysal, Washburn, Joseph, Wiggins, Roger C, Choi, Murim, Lifton, Richard P, Levy, Shawn, Han, Zhe, Salviati, Leonardo, Prokisch, Holger, Williams, David S, Pollak, Martin, Clarke, Catherine F, Pei, York, Antignac, Corinne, Hildebrandt, Friedhelm

“…Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has furthered the understanding of the pathogenesis of this disease. Here,…”
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Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis by Hultgren, Nan W., Fang, Jennifer S., Ziegler, Mary E., Ramirez, Ricardo N., Phan, Duc T. T., Hatch, Michaela M. S., Welch-Reardon, Katrina M., Paniagua, Antonio E., Kim, Lin S., Shon, Nathan N., Williams, David S., Mortazavi, Ali, Hughes, Christopher C. W.

“…Slug ( SNAI2 ), a member of the well-conserved Snail family of transcription factors, has multiple developmental roles, including in epithelial-to-mesenchymal…”
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Drusen in patient-derived hiPSC-RPE models of macular dystrophies by Galloway, Chad A., Dalvi, Sonal, Hung, Sandy S. C., MacDonald, Leslie A., Latchney, Lisa R., Wong, Raymond C. B., Guymer, Robyn H., Mackey, David A., Williams, David S., Chung, Mina M., Gamm, David M., Pébay, Alice, Hewitt, Alex W., Singh, Ruchira

“…Age-related macular degeneration (AMD) and related macular dystrophies (MDs) are a major cause of vision loss. However, the mechanisms underlying their…”
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Mismatch Repair Protein Defects and Microsatellite Instability in Malignant Pleural Mesothelioma by Arulananda, Surein, Thapa, Bibhusal, Walkiewicz, Marzena, Zapparoli, Giada V, Williams, David S, Dobrovic, Alexander, John, Thomas

“…Malignant pleural mesothelioma is an aggressive malignancy with limited systemic therapy options. Promising results have been reported with use of…”
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Non-toxic polymer nanovectors for improved delivery of dexamethasone by Ede, Benjamin C., Diamanti, Paraskevi, Williams, David S., Blair, Allison

“…Dexamethasone (Dex) is a highly insoluble front-line drug used in cancer therapy. Data from clinical trials indicates that the pharmacokinetics of Dex vary…”
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Three-dimensional organization of nascent rod outer segment disk membranes by Volland, Stefanie, Hughes, Louise C., Kong, Christina, Burgess, Barry L., Linberg, Kenneth A., Luna, Gabriel, Zhou, Z. Hong, Fisher, Steven K., Williams, David S.

“…The vertebrate photoreceptor cell contains an elaborate cilium that includes a stack of phototransductive membrane disks. The disk membranes are continually…”
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A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy by De Jong, Edwin, Williams, David S., Abdelmohsen, Loai K.E.A., Van Hest, Jan C.M., Zuhorn, Inge S.

“…The delivery of therapeutics to the brain is greatly hampered by the blood-brain barrier (BBB). The use of nanoparticles that can cross the BBB via the process…”
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Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration by Esteve-Rudd, Julian, Hazim, Roni A., Diemer, Tanja, Paniagua, Antonio E., Volland, Stefanie, Umapathy, Ankita, Williams, David S.

“…Stargardt macular dystrophy 3 (STGD3) is caused by dominant mutations in the ELOVL4 gene. Like other macular degenerations, pathogenesis within the retinal…”
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Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis by Jiang, Mei, Esteve-Rudd, Julian, Lopes, Vanda S, Diemer, Tanja, Lillo, Concepción, Rump, Agrani, Williams, David S

“…The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment…”
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Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity by Dávalos-Salas, Mercedes, Montgomery, Magdalene K., Reehorst, Camilla M., Nightingale, Rebecca, Ng, Irvin, Anderton, Holly, Al-Obaidi, Sheren, Lesmana, Analia, Scott, Cameron M., Ioannidis, Paul, Kalra, Hina, Keerthikumar, Shivakumar, Tögel, Lars, Rigopoulos, Angela, Gong, Sylvia J., Williams, David S., Yoganantharaja, Prusoth, Bell-Anderson, Kim, Mathivanan, Suresh, Gibert, Yann, Hiebert, Scott, Scott, Andrew M., Watt, Matthew J., Mariadason, John M.

“…Histone deacetylase 3 ( Hdac3 ) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulating lipid metabolism in the…”
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Stabilization and enhanced reactivity of actinorhodin polyketide synthase minimal complex in polymer-nucleotide coacervate droplets by Crosby, John, Treadwell, Tom, Hammerton, Michelle, Vasilakis, Konstantinos, Crump, Matthew P, Williams, David S, Mann, Stephen

“…Compartmentalization of the minimal complex of actinorhodin polyketide synthase in coacervate liquid droplets produces enhanced yields of shunt polyketides…”
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