Search Results - "David M. Ojcius"

Impact of COVID‐19 on dental education in the United States by Iyer, Parvati, Aziz, Kalid, Ojcius, David M.

“…Dental institutions in the United States are reeling from the consequences of the novel SARS‐CoV2 coronavirus, the causative agent of CODIV‐19. As oral health…”
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Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China by Yu, Fei, Du, Lanying, Ojcius, David M., Pan, Chungen, Jiang, Shibo

“…On 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 2019-nCoV by the World Health Organization…”
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Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis by Shimada, Kenichi, Crother, Timothy R., Karlin, Justin, Dagvadorj, Jargalsaikhan, Chiba, Norika, Chen, Shuang, Ramanujan, V. Krishnan, Wolf, Andrea J., Vergnes, Laurent, Ojcius, David M., Rentsendorj, Altan, Vargas, Mario, Guerrero, Candace, Wang, Yinsheng, Fitzgerald, Katherine A., Underhill, David M., Town, Terrence, Arditi, Moshe

“…We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling that licensed production of…”
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Lessons learned from the 2019-nCoV epidemic on prevention of future infectious diseases by Pan, Xingchen, Ojcius, David M., Gao, Tianyue, Li, Zhongsheng, Pan, Chunhua, Pan, Chungen

“…Only a month after the outbreak of pneumonia caused by 2019-nCoV, more than forty-thousand people were infected. This put enormous pressure on the Chinese…”
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Phytochemicals as Prebiotics and Biological Stress Inducers by Martel, Jan, Ojcius, David M., Ko, Yun-Fei, Young, John D.

“…Phytochemicals in fruits and vegetables produce health benefits, but questions remain regarding their bioavailability, molecular targets, and mechanism of…”
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Association between periodontal pathogens and systemic disease by Bui, Fiona Q, Almeida-da-Silva, Cassio Luiz Coutinho, Huynh, Brandon, Trinh, Alston, Liu, Jessica, Woodward, Jacob, Asadi, Homer, Ojcius, David M

“…A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease,…”
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Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota by Chang, Chih-Jung, Lin, Chuan-Sheng, Lu, Chia-Chen, Martel, Jan, Ko, Yun-Fei, Ojcius, David M., Tseng, Shun-Fu, Wu, Tsung-Ru, Chen, Yi-Yuan Margaret, Young, John D., Lai, Hsin-Chih

“…Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom used in traditional Chinese…”
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Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase by Saïd-Sadier, Najwane, Padilla, Eduardo, Langsley, Gordon, Ojcius, David M

“…Invasive aspergillosis (IA) is a life-threatening disease that occurs in immunodepressed patients when infected with Aspergillus fumigatus. This fungus is the…”
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Hormetic Effects of Phytochemicals on Health and Longevity by Martel, Jan, Ojcius, David M., Ko, Yun-Fei, Ke, Po-Yuan, Wu, Cheng-Yeu, Peng, Hsin-Hsin, Young, John D.

“…Caloric restriction, intermittent fasting, and exercise activate defensive cellular responses such as autophagy, DNA repair, and the induction of antioxidant…”
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Effects of obesity on depression: A role for inflammation and the gut microbiota by Schachter, Julieta, Martel, Jan, Lin, Chuan-Sheng, Chang, Chih-Jung, Wu, Tsung-Ru, Lu, Chia-Chen, Ko, Yun-Fei, Lai, Hsin-Chih, Ojcius, David M., Young, John D.

“…•Depression is caused by environmental, genetic and psychological factors.•Consumption of a high-fat diet induces obesity and chronic inflammation in the…”
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Is there an association between oral health and severity of COVID-19 complications? by Botros, Nathalie, Iyer, Parvati, Ojcius, David M

“…Most patients with severe complications from COVID-19 have underlying conditions such as obesity, diabetes, and hypertension. In parallel, there is growing…”
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The role of NOD-like receptors in innate immunity by Almeida-da-Silva, Cássio Luiz Coutinho, Savio, Luiz Eduardo Baggio, Coutinho-Silva, Robson, Ojcius, David M

“…The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways that can rapidly initiate the host response…”
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Immunotherapies for Neurodegenerative Diseases by Mortada, Ibrahim, Farah, Raymond, Nabha, Sanaa, Ojcius, David M., Fares, Youssef, Almawi, Wassim Y., Sadier, Najwane Said

“…The current treatments for neurodegenerative diseases are mostly symptomatic without affecting the underlying cause of disease. Emerging evidence supports a…”
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Sleep Deprivation and Neurological Disorders by Ray, Bipul, Tuladhar, Sunanda, Chidambaram, Saravana Babu, Sakharkar, Meena Kishore, Guillemin, Gilles J., Qoronfleh, M. Walid, Ojcius, David J., Mahalakshmi, Arehally M., Mohan, Surapaneni Krishna, Veeraraghavan, Vishnu Priya, Ihunwo, Amadi O., Ekpo, Okobi, Essa, Musthafa Mohamed, Bhat, Abid, Bishir, Muhammed, Chang, Sulie

“…Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs…”
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Salivary biomarkers for the diagnosis and monitoring of neurological diseases by Farah, Raymond, Haraty, Hayat, Salame, Ziad, Fares, Youssef, Ojcius, David M, Said Sadier, Najwane

“…Current research efforts on neurological diseases are focused on identifying novel disease biomarkers to aid in diagnosis, provide accurate prognostic…”
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Unveiling the mycobiota: The fungal frontier of human health by Iyer, Parvati, Ojcius, David M

“…The microbiota and its effect on health has been extensively studied over the past decade. In many studies, the term microbiota has become synonymous with the…”
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P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation by Hung, Shu-Chen, Choi, Chul Hee, Said-Sadier, Najwane, Johnson, Larry, Atanasova, Kalina Rosenova, Sellami, Hanen, Yilmaz, Özlem, Ojcius, David M

“…We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to…”
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ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages by Cruz, Cristiane M., Rinna, Alessandra, Forman, Henry Jay, Ventura, Ana L.M., Persechini, Pedro M., Ojcius, David M.

“…Secretion of the proinflammatory cytokines, interleukin (IL)-1β and IL-18, usually requires two signals. The first, due to microbial products such as…”
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Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells by Almeida-da-Silva, Cassio Luiz Coutinho, Matshik Dakafay, Harmony, Liu, Kaitlyn, Ojcius, David M.

“…A large body of evidence shows the harmful effects of cigarette smoke to oral and systemic health. More recently, a link between smoking and susceptibility to…”
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Is a return to nature a piece of the health puzzle? by Martel, Jan, Ojcius, David M

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