Search Results - "David L Caudell"

Animal Model To Study Klebsiella pneumoniae Gastrointestinal Colonization and Host-to-Host Transmission by Young, Taylor M, Bray, Andrew S, Nagpal, Ravinder K, Caudell, David L, Yadav, Hariom, Zafar, M Ammar

“…An important yet poorly understood facet of the life cycle of a successful pathogen is host-to-host transmission. Hospital-acquired infections (HAI) resulting…”
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Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model by Atkins, Hannah M, Bharadwaj, Manish S, O'Brien Cox, Anderson, Furdui, Cristina M, Appt, Susan E, Caudell, David L

“…Endometriosis is the growth of uterine lining (endometrium) outside of the uterus. In other chronic inflammatory diseases, mitochondrial dysfunction is…”
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Alzheimer disease-like neuropathologic changes in a geriatric baboon ( Papio hamadryas ) by Harrison, William T, Cline, J Mark, Caudell, David L, Huber, Hillary F, Shively, Carol A, Register, Thomas C, Craft, Suzanne, Struthers, Jason D

“…Alzheimer's disease (AD) is the most common cause of dementia in the elderly with the incidence rising exponentially after the age of 65 years. Unfortunately,…”
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The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia by Alexander, Peter M, Caudell, David L, Kucera, Gregory L, Pladna, Kristin M, Pardee, Timothy S

“…Philadelphia chromosome positive B cell acute lymphoblastic leukemia (Ph+ ALL) is an aggressive cancer of the bone marrow. The addition of tyrosine kinase…”
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Potential therapeutic action of nitrite in sickle cell disease by Wajih, Nadeem, Basu, Swati, Jailwala, Anuj, Kim, Hee Won, Ostrowski, David, Perlegas, Andreas, Bolden, Crystal A, Buechler, Nancy L, Gladwin, Mark T, Caudell, David L, Rahbar, Elaheh, Alexander-Miller, Martha A, Vachharajani, Vidula, Kim-Shapiro, Daniel B

“…Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated…”
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Epizootic Yersinia enterocolitica in captive African green monkeys ( Chlorocebus aethiops sabaeus ) by Balamayooran, Gayathriy, Atkins, Hannah M, Andrews, Rachel N, Michalson, Kristofer T, Hutchison, A Robert, LeGrande, Andre C, Wilson, Quentin N, Gee, Melaney K, Aycock, S Tyler, Jorgensen, Matthew J, Young, Richard W, Kock, Nancy D, Caudell, David L

“…is a Gram-negative bacterium that typical results in enterocolitis in humans and poses significant worldwide risks to public health. An outbreak of yersiniosis…”
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Alzheimer disease-like neuropathologic changes in a geriatric baboon (Papio hamadryas) by William T Harrison, J Mark Cline, David L Caudell, Hillary F Huber, Carol A Shively, Thomas C Register, Suzanne Craft, Jason D Struthers

“…Importance: Alzheimer's disease (AD) is the most common cause of dementia in the elderly with the incidence rising exponentially after the age of 65 years…”
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The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML by Cook, Guerry J, Caudell, David L, Elford, Howard L, Pardee, Timothy S

“…Acute Myeloid Leukemia (AML) is an aggressive malignancy which leads to marrow failure, and ultimately death. There is a desperate need for new therapeutics…”
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Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus by Shimp, Samuel K, Chafin, Cristen B, Regna, Nicole L, Hammond, Sarah E, Read, Molly A, Caudell, David L, Rylander, MarissaNichole, Reilly, Christopher M

“…Elevated expression of heat shock protein 90 (HSP90) has been found in kidneys and serum of systemic lupus erythematosus (SLE) patients and MRL/Mp- Fas lpr /…”
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Tetravalent dengue DNA vaccine is not immunogenic when delivered by retrograde infusion into salivary glands by El Helou, Guy, Ponzio, Todd A, Goodman, Joseph F, Blevins, Maria, Caudell, David L, Raviprakash, Kanakatte S, Ewing, Daniel, Williams, Maya, Porter, Kevin R, Sanders, John W

“…A tetravalent DNA vaccine for Dengue virus is under development but has not yet achieved optimal immunogenicity. Salivary glands vaccination has been reported…”
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Canine Snake-Eye Myelopathy: Clinical, Magnetic Resonance Imaging, and Pathologic Findings in Four Cases by Rossmeisl, Jr, John H, Cecere, Thomas E, Kortz, Gregg D, Geiger, David A, Shinn, Richard L, Hinckley, Jonathan, Caudell, David L, Stahle, Jessica A

“…Intramedullary signal change (ISC) is a non-specific finding that is frequently observed on magnetic resonance imaging (MRI) examinations of the canine spinal…”
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Effects of nitrite and far-red light on coagulation by Wajih, Nadeem, Alipour, Elmira, Rigal, Fernando, Zhu, Jiqing, Perlegas, Andreas, Caudell, David L., Kim-Shapiro, Daniel

“…Nitric oxide, NO, has been explored as a therapeutic agent to treat thrombosis. In particular, NO has potential in treating mechanical device-associated…”
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Systemic immune response to a CD40 agonist antibody in nonhuman primates by Caudell, David L, Dugan, Gregory O, Babitzki, Galina, Schubert, Christine, Braendli-Baiocco, Annamaria, Wasserman, Ken, Acona, Gonzalo, Stern, Martin, Passioukov, Alexandre, Cline, J Mark, Charo, Jehad

“…The cell surface molecule CD40 is a member of the tumor necrosis factor receptor superfamily and is broadly expressed by immune cells including B cells,…”
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Long-Term Immunological Consequences of Radiation Exposure in a Diverse Cohort of Rhesus Macaques by French, Matthew J., Wuerker, Ryan, Dugan, Greg, Olson, John D., Sanders, Brittany R., Tooze, Janet A., Caudell, David L., Cline, J. Mark, Sempowski, Gregory D., Macintyre, Andrew N.

“…The aim of this study was to develop an improved understanding of the delayed immunologic effects of acute total body irradiation (TBI) using a diverse cohort…”
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Total-Body Irradiation Is Associated With Increased Incidence of Mesenchymal Neoplasia in a Radiation Late Effects Cohort of Rhesus Macaques (Macaca mulatta) by Sills, W. Shane, Tooze, Janet A., Olson, John D., Caudell, David L., Dugan, Greg O., Johnson, Brendan J., Kock, Nancy D., Andrews, Rachel N., Schaaf, George W., Lang, Richard A., Cline, J. Mark

“…Cancer is a severe delayed effect of acute radiation exposure. Total-body irradiation has been associated with an increased risk of solid cancer and leukemia…”
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Mechanisms of Human Erythrocytic Bioactivation of Nitrite by Liu, Chen, Wajih, Nadeem, Liu, Xiaohua, Basu, Swati, Janes, John, Marvel, Madison, Keggi, Christian, Helms, Christine C., Lee, Amber N., Belanger, Andrea M., Diz, Debra I., Laurienti, Paul J., Caudell, David L., Wang, Jun, Gladwin, Mark T., Kim-Shapiro, Daniel B.

“…Nitrite signaling likely occurs through its reduction to nitric oxide (NO). Several reports support a role of erythrocytes and hemoglobin in nitrite reduction,…”
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The TLR2/TLR6 ligand FSL-1 mitigates radiation-induced hematopoietic injury in mice and nonhuman primates by Brickey, W June, Caudell, David L, Macintyre, Andrew N, Olson, John D, Dai, Yanwan, Li, Sirui, Dugan, Gregory O, Bourland, J Daniel, O'Donnell, Lisa M, Tooze, Janet A, Huang, Guannan, Yang, Shuangshuang, Guo, Hao, French, Matthew N, Schorzman, Allison N, Zamboni, William C, Sempowski, Gregory D, Li, Zhiguo, Owzar, Kouros, Chao, Nelson J, Cline, J Mark, Ting, Jenny P Y

“…Thrombocytopenia, hemorrhage, anemia, and infection are life-threatening issues following accidental or intentional radiation exposure. Since few therapeutics…”
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Improved Antitumor Activity of the Fluoropyrimidine Polymer CF10 in Preclinical Colorectal Cancer Models through Distinct Mechanistic and Pharmacologic Properties by Gmeiner, William H, Dominijanni, Anthony, Haber, Alex O, Ghiraldeli, Lais P, Caudell, David L, D'Agostino, Jr, Ralph, Pasche, Boris C, Smith, Thomas L, Deng, Zhiyong, Kiren, Sezgin, Mani, Chinnadurai, Palle, Komaraiah, Brody, Jonathan R

“…Chemotherapy regimens that include 5-fluorouracil (5-FU) are central to colorectal cancer treatment; however, risk/benefit concerns limit 5-FU's use,…”
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Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo by Regna, Nicole L, Chafin, Cristen B, Hammond, Sarah E, Puthiyaveetil, Abdul G, Caudell, David L, Reilly, Christopher M

“…Abstract We sought to determine if a specific class I and II HDAC inhibitor (ITF2357) was able to decrease disease in lupus-prone NZB/W mice through regulation…”
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Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies by Yamaleyeva, Liliya M, Chappell, Mark C, Brosnihan, K Bridget, Anton, Lauren, Caudell, David L, Shi, Sara, McGee, Carolynne, Pirro, Nancy, Gallagher, Patricia E, Taylor, Robert N, Merrill, David C, Mertz, Heather L

“…The role of the endogenous apelin system in pregnancy is not well understood. Apelin's actions in pregnancy are further complicated by the expression of…”
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