Search Results - "David J. Gonzalez"

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules by Markmiller, Sebastian, Soltanieh, Sahar, Server, Kari L., Mak, Raymond, Jin, Wenhao, Fang, Mark Y., Luo, En-Ching, Krach, Florian, Yang, Dejun, Sen, Anindya, Fulzele, Amit, Wozniak, Jacob M., Gonzalez, David J., Kankel, Mark W., Gao, Fen-Biao, Bennett, Eric J., Lécuyer, Eric, Yeo, Gene W.

“…Stress granules (SGs) are transient ribonucleoprotein (RNP) aggregates that form during cellular stress and are increasingly implicated in human…”
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Enhancing Confusion Entropy (CEN) for binary and multiclass classification by Delgado, Rosario, Núñez-González, J David

“…Different performance measures are used to assess the behaviour, and to carry out the comparison, of classifiers in Machine Learning. Many measures have been…”
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Racial Disparities in Climate Change-Related Health Effects in the United States by Berberian, Alique G., Gonzalez, David J. X., Cushing, Lara J.

“…Purpose of Review Climate change is causing warming over most parts of the USA and more extreme weather events. The health impacts of these changes are not…”
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Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer by Singh, Vishal, Yeoh, Beng San, Chassaing, Benoit, Xiao, Xia, Saha, Piu, Aguilera Olvera, Rodrigo, Lapek, John D., Zhang, Limin, Wang, Wei-Bei, Hao, Sijie, Flythe, Michael D., Gonzalez, David J., Cani, Patrice D., Conejo-Garcia, Jose R., Xiong, Na, Kennett, Mary J., Joe, Bina, Patterson, Andrew D., Gewirtz, Andrew T., Vijay-Kumar, Matam

“…Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly,…”
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Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A by Yamanaka, Kazuya, Reynolds, Kirk A., Kersten, Roland D., Ryan, Katherine S., Gonzalez, David J., Nizet, Victor, Dorrestein, Pieter C., Moore, Bradley S.

“…Recent developments in next-generation sequencing technologies have brought recognition of microbial genomes as a rich resource for novel natural product…”
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Historic redlining and the siting of oil and gas wells in the United States by Gonzalez, David J. X., Nardone, Anthony, Nguyen, Andrew V., Morello-Frosch, Rachel, Casey, Joan A.

“…Background The presence of active or inactive (i.e., postproduction) oil and gas wells in neighborhoods may contribute to ongoing pollution. Racially…”
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Kinetic profiling of metabolic specialists demonstrates stability and consistency of in vivo enzyme turnover numbers by Heckmann, David, Campeau, Anaamika, Lloyd, Colton J., Phaneuf, Patrick V., Hefner, Ying, Carrillo-Terrazas, Marvic, Feist, Adam M., Gonzalez, David J., Palsson, Bernhard O.

“…Enzyme turnover numbers (k cats) are essential for a quantitative understanding of cells. Because k cats are traditionally measured in low-throughput assays,…”
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Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis by Tagliabracci, Vincent S, Engel, James L, Wiley, Sandra E, Xiao, Junyu, Gonzalez, David J, Nidumanda Appaiah, Hitesh, Koller, Antonius, Nizet, Victor, White, Kenneth E, Dixon, Jack E

“…The family with sequence similarity 20, member C (Fam20C) has recently been identified as the Golgi casein kinase. Fam20C phosphorylates secreted proteins on…”
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Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia by Campeau, Anaamika, Mills, Robert H., Stevens, Toer, Rossitto, Leigh-Ana, Meehan, Michael, Dorrestein, Pieter, Daly, Rebecca, Nguyen, Tanya T., Gonzalez, David J., Jeste, Dilip V., Hook, Vivian

“…Schizophrenia is a devastating psychiatric illness that detrimentally affects a significant portion of the worldwide population. Aging of schizophrenia…”
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Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide by Corriden, Ross, Hollands, Andrew, Olson, Joshua, Derieux, Jaclyn, Lopez, Justine, Chang, John T., Gonzalez, David J., Nizet, Victor

“…Tamoxifen is a selective oestrogen receptor modulator widely used for the treatment of breast cancer. In addition to its activity as an oestrogen receptor…”
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Intrinsic disorder in the human vitreous proteome by Antonietti, Michael, Taylor Gonzalez, David J., Djulbegovic, Mak B., Gameiro, Gustavo R., Uversky, Vladimir N., Sridhar, Jayanth, Karp, Carol L.

“…The vitreous is a vital component of the eye, occupying a substantial portion of its volume and maintaining its structure. This study delves into the presence…”
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Proteome allocation is linked to transcriptional regulation through a modularized transcriptome by Patel, Arjun, McGrosso, Dominic, Hefner, Ying, Campeau, Anaamika, Sastry, Anand V., Maurya, Svetlana, Rychel, Kevin, Gonzalez, David J., Palsson, Bernhard O.

“…It has proved challenging to quantitatively relate the proteome to the transcriptome on a per-gene basis. Recent advances in data analytics have enabled a…”
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Intrinsic disorder may drive the interaction of PROS1 and MERTK in uveal melanoma by Djulbegovic, Mak, Taylor Gonzalez, David J., Antonietti, Michael, Uversky, Vladimir N., Shields, Carol L., Karp, Carol L.

“…Class 2 uveal melanomas are associated with the inactivation of the BRCA1 ((breast cancer type 1 susceptibility protein)-associated protein 1 (BAP1)) gene…”
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Essential metabolism for a minimal cell by Breuer, Marian, Earnest, Tyler M, Merryman, Chuck, Wise, Kim S, Sun, Lijie, Lynott, Michaela R, Hutchison, Clyde A, Smith, Hamilton O, Lapek, John D, Gonzalez, David J, de Crécy-Lagard, Valérie, Haas, Drago, Hanson, Andrew D, Labhsetwar, Piyush, Glass, John I, Luthey-Schulten, Zaida

“…JCVI-syn3A, a robust minimal cell with a 543 kbp genome and 493 genes, provides a versatile platform to study the basics of life. Using the vast amount of…”
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Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model by Lordén, Gema, Wozniak, Jacob M., Doré, Kim, Dozier, Lara E., Cates-Gatto, Chelsea, Patrick, Gentry N., Gonzalez, David J., Roberts, Amanda J., Tanzi, Rudolph E., Newton, Alexandra C.

“…Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining cellular homeostasis. Whereas loss-of-function mutations are…”
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Intrinsic Disorder in the Human Tear Proteome by Taylor Gonzalez, David J, Djulbegovic, Mak, Antonietti, Michael, Cordova, Matthew, Dayhoff, 2nd, Guy W, Mattes, Robby, Galor, Anat, Uversky, Vladimir N, Karp, Carol L

“…We aimed to characterize the proteome of human tears and assess for the presence of intrinsically disordered proteins (IDPs). IDPs, despite lacking a rigid…”
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Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement and inflammation modulators by Sanchez, Concepcion, Campeau, Anaamika, Liu-Bryan, Ru, Mikuls, Ted R., O’Dell, James R., Gonzalez, David J., Terkeltaub, Robert

“…Urate-lowering treatment (ULT) to target with xanthine oxidase inhibitors (XOIs) paradoxically causes early increase in gouty arthritis flares. Because delayed…”
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Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules by Kersten, Roland D, Ziemert, Nadine, Gonzalez, David J, Duggan, Brendan M, Nizet, Victor, Dorrestein, Pieter C, Moore, Bradley S

“…Glycosyl groups are an essential mediator of molecular interactions in cells and on cellular surfaces. There are very few methods that directly relate…”
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Semantically enhanced network analysis for influencer identification in online social networks by Ríos, Sebastián A., Aguilera, Felipe, Nuñez-Gonzalez, J. David, Graña, Manuel

“…Influencers in a social network are members that have greater effect in the online social network (OSN) than the average member. In the specific social…”
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Location-specific signatures of Crohn's disease at a multi-omics scale by Gonzalez, Carlos G, Mills, Robert H, Zhu, Qiyun, Sauceda, Consuelo, Knight, Rob, Dulai, Parambir S, Gonzalez, David J

“…Crohn's disease (CD), an inflammatory bowel disease (IBD) subtype, results from pathologic interactions between host cells and its resident gut microbes. CD…”
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