Search Results - "David J. Britton"

Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets by Khorsandi, Shirin Elizabeth, Dokal, Arran D, Rajeeve, Vinothini, Britton, David J, Illingworth, Megan S, Heaton, Nigel, Cutillas, Pedro R

“…Cholangiocarcinoma is a form of hepatobiliary cancer with an abysmal prognosis. Despite advances in our understanding of cholangiocarcinoma pathophysiology and…”
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MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression by Frampton, Adam E, Castellano, Leandro, Colombo, Teresa, Giovannetti, Elisa, Krell, Jonathan, Jacob, Jimmy, Pellegrino, Loredana, Roca-Alonso, Laura, Funel, Niccola, Gall, Tamara M.H, De Giorgio, Alexander, Pinho, Filipa G, Fulci, Valerio, Britton, David J, Ahmad, Raida, Habib, Nagy A, Coombes, R. Charles, Harding, Victoria, Knösel, Thomas, Stebbing, Justin, Jiao, Long R

“…Background & Aims There has not been a broad analysis of the combined effects of altered activities of microRNAs (miRNAs) in pancreatic ductal adenocarcinoma…”
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Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305 by Held, Jason M, Britton, David J, Scott, Gary K, Lee, Elbert L, Schilling, Birgit, Baldwin, Michael A, Gibson, Bradford W, Benz, Christopher C

“…Phosphorylation of estrogen receptor-α (ERα) is critical for its transcription factor activity and may determine its predictive and therapeutic value as a…”
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A Novel Serine Phosphorylation Site Detected in the N-Terminal Domain of Estrogen Receptor Isolated from Human Breast Cancer Cells by Britton, David J., Scott, Gary K., Schilling, Birgit, Atsriku, Christian, Held, Jason M., Gibson, Bradford W., Benz, Christopher C., Baldwin, Michael A.

“…Activated estrogen receptor (ERα) plays a critical role in breast cancer development and is a major target for drug treatment. Serine phosphorylation within…”
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Targeted Quantitation of Site-Specific Cysteine Oxidation in Endogenous Proteins Using a Differential Alkylation and Multiple Reaction Monitoring Mass Spectrometry Approach by Held, Jason M., Danielson, Steven R., Behring, Jessica B., Atsriku, Christian, Britton, David J., Puckett, Rachel L., Schilling, Birgit, Campisi, Judith, Benz, Christopher C., Gibson, Bradford W.

“…Reactive oxygen species (ROS) are both physiological intermediates in cellular signaling and mediators of oxidative stress. The cysteine-specific…”
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Phosphoproteomics predict response to midostaurin plus chemotherapy in independent cohorts of FLT3-mutated acute myeloid leukaemia by Borek, Weronika E., Nobre, Luis, Pedicona, S. Federico, Campbell, Amy E., Christopher, Josie A., Nawaz, Nazrath, Perkins, David N., Moreno-Cardoso, Pedro, Kelsall, Janet, Ferguson, Harriet R., Patel, Bela, Gallipoli, Paolo, Arruda, Andrea, Ambinder, Alex J., Thompson, Andrew, Williamson, Andrew, Ghiaur, Gabriel, Minden, Mark D., Gribben, John G., Britton, David J., Cutillas, Pedro R., Dokal, Arran D.

“…Acute myeloid leukaemia (AML) is a bone marrow malignancy with poor prognosis. One of several treatments for AML is midostaurin combined with intensive…”
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Systematic Mapping of Posttranslational Modifications in Human Estrogen Receptor-α with Emphasis on Novel Phosphorylation Sites by Atsriku, Christian, Britton, David J., Held, Jason M., Schilling, Birgit, Scott, Gary K., Gibson, Bradford W., Benz, Christopher C., Baldwin, Michael A.

“…A systematic study of posttranslational modifications of the estrogen receptor isolated from the MCF-7 human breast cancer cell line is reported. Proteolysis…”
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S124: PHOSPHOPROTEOMICS ACCURATELY PREDICTS RESPONSES TO MIDOSTAURIN PLUS CHEMOTHERAPY IN TWO INDEPENDENT COHORTS OF FLT3 MUTANT‐POSITIVE ACUTE MYELOID LEUKAEMIA by Dokal, Arran, Borek, Weronika E., Nobre, Luis, Federico Pedicona, Salvatore, Wrench, Bela, Gallipoli, Paolo, Arruda, Andrea, Campbell, Amy E., Nawaz, Nazrath, Ferguson, Harriet R., Perkins, David N., Moreno‐Cardoso, Pedro, Thompson, Andrew, Williamson, Andrew J.K., Minden, Mark D., Gribben, John G., Britton, David J., Cutillas, Pedro R.

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Chain transfer to polymer in emulsion copolymerizations by Britton, David J., Lovell, Peter A., Heatley, Frank, Venkatesh, Rajan

“…Chain transfer to polymer in emulsion copolymerizations of (i) vinyl acetate (VAc) with n‐butyl acrylate (BA) and (ii) BA/acrylic acid with (a) methyl…”
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Proteomic Analysis Directs Effective Drug Selection in Relapsed AML By Quantifying Drug Targets by Britton, David J, Wilkes, Edmund, Casado, Pedro, Rajeeve, Vinothini, Fitzgibbon, Jude, Gribben, John, Cutillas, Pedro R

“…Introduction: Standard therapy for acute myeloid leukaemia (AML) generally includes intense induction with daunorubicin (D) on days 1-3 and cytarabine (A) on…”
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Phosphoproteomics predict response to midostaurin plus chemotherapy in independent cohorts of FLT3-mutated acute myeloid leukaemiaResearch in context by Weronika E. Borek, Luis Nobre, S. Federico Pedicona, Amy E. Campbell, Josie A. Christopher, Nazrath Nawaz, David N. Perkins, Pedro Moreno-Cardoso, Janet Kelsall, Harriet R. Ferguson, Bela Patel, Paolo Gallipoli, Andrea Arruda, Alex J. Ambinder, Andrew Thompson, Andrew Williamson, Gabriel Ghiaur, Mark D. Minden, John G. Gribben, David J. Britton, Pedro R. Cutillas, Arran D. Dokal

“…Background: Acute myeloid leukaemia (AML) is a bone marrow malignancy with poor prognosis. One of several treatments for AML is midostaurin combined with…”
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Liquid chromatography-multiple reaction monitoring mass spectrometry biomarker quantification for breast cancer patient assessment by Chen, Yi, Britton, David J., Wood, Elizabeth R., Han, Hyo S., Magliocco, Anthony M., Pike, Ian, Koomen, John M

“…Abstract only…”
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Abstract 2494: Liquid chromatography-multiple reaction monitoring mass spectrometry biomarker quantification for breast cancer patient assessment by Chen, Yi, Britton, David J., Wood, Elizabeth R., Magliocco, Anthony M., Pike, Ian, Koomen, John M.

“…Abstract Introduction: A quantitative mass spectrometry platform has been developed for measuring biomarkers of protein expression and phosphorylation in…”
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Abstract 2491: Quantification of biomarker expression, phosphorylation, and mutation in cancer using TMT labeling prior to liquid chromatography-multiple reaction monitoring mass spectrometry by Chen, Yi, Britton, David J., Paraiso, Kim, Fedorenko, Inna, Wood, Elizabeth R., Magliocco, Anthony, Sondak, Vernon K., Smalley, Keiran, Pike, Ian, Koomen, John M.

“…Abstract Introduction: Quantitative mass spectrometry assays using the Tandem Mass Tag (TMT) labeling strategy have been developed for measuring biologically…”
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Tubulin beta-3: A novel tissue diagnostic marker for intrahepatic peripheral cholangiocarcionoma by Britton, David J., Zen, Yoh, Mitra, Vikram, Jung, Stephan, Loessner, Christopher, Ward, Malcolm, Pike, Ian, Sarker, Debashis, Heaton, Nigel, Quaglia, Alberto

“…Abstract only…”
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Identification of new liver tumor biomarkers using proteomics by Maimonis, Peter J., Zen, Yoh, Britton, David J., Brand, Andrew, Ward, Malcolm, Pike, Ian, Quaglia, Alberto

“…Abstract only e21091 Background: It is crucial to identify new biomarkers that help diagnose cancers at an early stage and contribute to the development of new…”
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Abstract 4810: Multiplexed immunoprecipitation-liquid chromatography-multiple reaction monitoring mass spectrometry quantification of protein expression and phosphorylation for breast cancer biomarkers by Chen, Yi, Britton, David J., Wood, Elizabeth R., Pike, Ian, Koomen, John M.

“…Abstract Introduction: Estrogen receptor alpha (ER alpha), progesterone receptor B (PR B), and the receptor tyrosine kinase, Her2, are tumor markers classified…”
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Abstract 3933: ERα phosphorylation patterns at hinge domain Ser294 and Ser305 differentiate ligand-dependent from ligand-independent receptor activation by Scott, Gary K., Held, Jason, Britton, David J., Lee, Elbert, Schilling, Birgit, Baldwin, Michael, Gibson, Brad W., Benz, Christopher C.

“…Abstract Domain-specific phosphorylation of estrogen receptor alpha (ERα) is critical for its transcription factor activity and may determine its predictive…”
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Systematic Mapping of Posttranslational Modifications in Human Estrogen Receptor-α with Emphasis on Novel Phosphorylation Sites by Christian Atsriku, David J. Britton, Jason M. Held, Birgit Schilling, Gary K. Scott, Bradford W. Gibson, Christopher C. Benz, Michael A. Baldwin

“…A systematic study of posttranslational modifications of the estrogen receptor isolated from the MCF-7 human breast cancer cell line is reported. Proteolysis…”
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Systematic Mapping of Posttranslational Modifications in Human Estrogen Receptor-α with Emphasis on Novel Phosphorylation SitesS by Atsriku, Christian, Britton, David J., Held, Jason M., Schilling, Birgit, Scott, Gary K., Gibson, Bradford W., Benz, Christopher C., Baldwin, Michael A.

“…A systematic study of posttranslational modifications of the estrogen receptor isolated from the MCF-7 human breast cancer cell line is reported. Proteolysis…”
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