Search Results - "David J Braun"

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling by Späni, Claudia B., Braun, David J., Van Eldik, Linda J.

“…•Sex is an understudied variable in TBI research.•Sex and hormonal status at time of injury influence different outcome measures.•Female mice show a stronger…”
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Theory of Fast Walking With Human-Driven Load-Carrying Robot Exoskeletons by Zhang, Tiange, Braun, David J.

“…Reaching and maintaining high walking speeds is challenging for a human when carrying extra weight, such as walking with a heavy backpack. Robotic limbs can…”
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Variable Stiffness Spring Actuators for Low-Energy-Cost Human Augmentation by Braun, David J., Chalvet, Vincent, Chong, Tze-Hao, Apte, Salil S., Hogan, Neville

“…Theoretical studies suggest and experimental evidence confirms that maintaining and changing human joint stiffness by coactivated antagonistic muscles are…”
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Optimization and validation of a modified radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury by Macheda, Teresa, Roberts, Kelly N, Morganti, Josh M, Braun, David J, Bachstetter, Adam D

“…Cognitive impairments can be a significant problem after a traumatic brain injury (TBI), which affects millions worldwide each year. There is a need for…”
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Early chronic suppression of microglial p38α in a model of Alzheimer's disease does not significantly alter amyloid-associated neuropathology by Braun, David J, Frazier, Hilaree N, Davis, Verda A, Coleman, Meggie J, Rogers, Colin B, Van Eldik, Linda J

“…The p38 alpha mitogen-activated protein kinase (p38α) is linked to both innate and adaptive immune responses and is under investigation as a target for drug…”
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Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer's disease by Braun, David J, Dimayuga, Edgardo, Morganti, Josh M, Van Eldik, Linda J

“…Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer's disease (AD) in elderly populations. While…”
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Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology by Braun, David J, Powell, David K, McLouth, Christopher J, Roy, Saktimayee M, Watterson, D Martin, Van Eldik, Linda J

“…Alzheimer's disease (AD) is the leading cause of dementia in the elderly, but therapeutic options are lacking. Despite long being able to effectively treat the…”
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Editorial: Modulation of neuroimmune systems to preserve brain function in aging and dementia by Braun, David J, Weekman, Erica M, Gordon, Marcia N, Späni, Claudia B

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Actuated Dynamic Walking in a Seven-Link Biped Robot by Braun, David J., Mitchell, Jason E., Goldfarb, Michael

“…The authors have previously described a method for enabling fully actuated biped walking without prescribing joint angle trajectories or imposing kinematic…”
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Exogenous Short Chain Fatty Acid Effects in APP/PS1 Mice by Zajac, Diana J, Shaw, Benjamin C, Braun, David J, Green, Stefan J, Morganti, Joshua M, Estus, Steven

“…Elucidating the impact of the gut microbiome on Alzheimer's Disease (AD) is an area of intense interest. Short chain fatty acids (SCFAs) are major microbiota…”
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In vivo Brainstem Imaging in Alzheimer's Disease: Potential for Biomarker Development by Braun, David J, Van Eldik, Linda J

“…The dearth of effective treatments for Alzheimer's disease (AD) is one of the largest public health issues worldwide, costing hundreds of billions of dollars…”
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Conditional Depletion of Hippocampal Brain-Derived Neurotrophic Factor Exacerbates Neuropathology in a Mouse Model of Alzheimer’s Disease by Braun, David J., Kalinin, Sergey, Feinstein, Douglas L.

“…Damage occurring to noradrenergic neurons in the locus coeruleus (LC) contributes to the evolution of neuroinflammation and neurodegeneration in a variety of…”
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A small molecule p38α MAPK inhibitor, MW150, attenuates behavioral deficits and neuronal dysfunction in a mouse model of mixed amyloid and vascular pathologies by Frazier, Hilaree N., Braun, David J., Bailey, Caleb S., Coleman, Meggie J., Davis, Verda A., Dundon, Stephen R., McLouth, Christopher J., Muzyk, Hana C., Powell, David K., Rogers, Colin B., Roy, Saktimayee M., Van Eldik, Linda J.

“…Inhibition of p38 alpha mitogen activated protein kinase (p38α) has shown great promise as a treatment for Alzheimer's disease (AD) in preclinical tests…”
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Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia by Braun, David J., Abner, Erin, Bakshi, Vikas, Goulding, Danielle S., Grau, Elizabeth M., Lin, Ai-Ling, Norris, Christopher M., Sudduth, Tiffany L., Webster, Scott J., Wilcock, Donna M., Van Eldik, Linda J.

“…Elevated homocysteine in the blood, or hyperhomocysteinemia, is a recognized risk factor for multiple causes of dementia including Alzheimer’s disease. While…”
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Positive-Negative Stiffness Actuators by Braun, David J., Chalvet, Vincent, Dahiya, Abhinav

“…Compliant actuators are typically designed to possess a tunable positive stiffness characteristic in order to generate restoring force upon displacement. These…”
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Enhancing Mobility With Quasi-Passive Variable Stiffness Exoskeletons by Sutrisno, Amanda, Braun, David J.

“…Shoes were invented to provide user comfort using rubber soles, despite marginal improvement in human mobility. Unlike shoes, current lower-limb exoskeletons…”
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Design of Parallel Variable Stiffness Actuators by Mathews, Chase W., Braun, David J.

“…Direct-drive motors (DDMs) have been increasingly used for robot actuation because they provide high-fidelity torque control, but they typically have low…”
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Iterative Online Optimal Feedback Control by Chen, Yuqing, Braun, David J.

“…This article proposes a data-driven iterative feedback control method to efficiently solve finite time horizon, nonlinear, input constrained optimal control…”
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Criterion for the Design of Low-Power Variable Stiffness Mechanisms by Chalvet, Vincent, Braun, David J.

“…Designing robotic systems capable of low-power operation, inherent to their compliant actuation, has been elusive in practical application. In this paper, we…”
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Hardware-in-the-Loop Iterative Optimal Feedback Control Without Model-Based Future Prediction by Chen, Yuqing, Braun, David J.

“…Optimal control provides a systematic approach to control robots. However, computing optimal controllers for hardware-in-the-loop control is sensitively…”
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