Search Results - "David J Bell"
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Rapid acquisition and model-based analysis of cell-free transcription–translation reactions from nonmodel bacteria
Published in Proceedings of the National Academy of Sciences - PNAS (08-05-2018)“…Native cell-free transcription–translation systems offer a rapid route to characterize the regulatory elements (promoters, transcription factors) for gene…”
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Physiotherapists clinical reasoning to prescribe exercise for patients with chronic pain: A qualitative study research protocol
Published in PloS one (01-12-2023)“…Background Physiotherapists' play a key role in the management of chronic pain, and as part of the National Institute for Health and Care Excellence (NICE)…”
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Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast
Published in Nature communications (04-05-2017)“…Fungi are a valuable source of enzymatic diversity and therapeutic natural products including antibiotics. Here we engineer the baker’s yeast Saccharomyces…”
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Reconstituting the complete biosynthesis of D-lysergic acid in yeast
Published in Nature communications (07-02-2022)“…The ergot alkaloids are a class of natural products known for their pharmacologically privileged molecular structure that are used in the treatment of…”
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Efficacy and safety of a patch vaccine containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase 3, randomised, double-blind, placebo-controlled field trial in travellers from Europe to Mexico and Guatemala
Published in The Lancet infectious diseases (01-03-2014)“…Summary Background Enterotoxigenic Escherichia coli (ETEC) is a major cause of travellers' diarrhoea. We investigated the efficacy and safety of a skin-patch…”
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Intrinsic calf factors associated with the behavior of healthy pre-weaned group-housed dairy-bred calves
Published in Frontiers in veterinary science (03-08-2023)“…Technology-derived behaviors are researched for disease detection in artificially-reared calves. Whilst existing studies demonstrate differences in behaviors…”
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The Effect of the Climatic Housing Environment on the Growth of Dairy-Bred Calves in the First Month of Life on a Scottish Farm
Published in Animals (Basel) (27-08-2021)“…Calf housing is naturally thermodynamic, with interactions between various elements such as wind speed, air temperature, and humidity. This study investigated…”
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First confirmed case of Crimean-Congo haemorrhagic fever in the UK
Published in The Lancet (British edition) (26-10-2013)“…Despite intravenous ribavirin, the patient's condition deteriorated, with fluctuating Glasgow Coma Scale scores, and rising respiratory rate and pulse. 60 h…”
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Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi
Published in Malaria journal (26-08-2009)“…Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study,…”
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10
Building a global alliance of biofoundries
Published in Nature communications (09-05-2019)“…Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology…”
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Late Ebola virus relapse causing meningoencephalitis: a case report
Published in The Lancet (British edition) (30-07-2016)“…Summary Background There are thousands of survivors of the 2014 Ebola outbreak in west Africa. Ebola virus can persist in survivors for months in…”
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A Cell-Free Biosensor for Detecting Quorum Sensing Molecules in P. aeruginosa-Infected Respiratory Samples
Published in ACS synthetic biology (15-12-2017)“…Synthetic biology designed cell-free biosensors are a promising new tool for the detection of clinically relevant biomarkers in infectious diseases. Here, we…”
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UK malaria treatment guidelines 2016
Published in The Journal of infection (01-06-2016)“…Summary 1.Malaria is the tropical disease most commonly imported into the UK, with 1300–1800 cases reported each year, and 2–11 deaths. 2. Approximately three…”
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Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi
Published in PloS one (13-02-2008)“…In Malawi, there has been a return of Plasmodium falciparum sensitivity to chloroquine (CQ) since sulfadoxine-pyrimethamine (SP) replaced CQ as first line…”
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Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy
Published in The EMBO journal (21-06-2006)“…The obligatory heterodimerization of the GABAB receptor (GBR) raises fundamental questions about molecular mechanisms controlling its signaling efficacy. Here,…”
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Modular Metabolic Engineering and Synthetic Coculture Strategies for the Production of Aromatic Compounds in Yeast
Published in ACS synthetic biology (16-06-2023)“…Microbial-derived aromatics provide a sustainable and renewable alternative to petroleum-derived chemicals. In this study, we used the model yeast…”
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EcoFlex: A Multifunctional MoClo Kit for E. coli Synthetic Biology
Published in ACS synthetic biology (21-10-2016)“…Golden Gate cloning is a prominent DNA assembly tool in synthetic biology for the assembly of plasmid constructs often used in combinatorial pathway…”
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Engineering a Model Cell for Rational Tuning of GPCR Signaling
Published in Cell (18-04-2019)“…G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to respond to specific cues in their environment. However, the relationship…”
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Plasmodium falciparum Strains Harboring Dihydrofolate Reductase with the I164L Mutation Are Absent in Malawi and Zambia Even under Antifolate Drug Pressure
Published in Antimicrobial Agents and Chemotherapy (01-11-2008)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Population Pharmacokinetic Properties of Sulfadoxine and Pyrimethamine: a Pooled Analysis To Inform Optimal Dosing in African Children with Uncomplicated Malaria
Published in Antimicrobial agents and chemotherapy (01-05-2018)“…Sulfadoxine-pyrimethamine with amodiaquine is recommended by the World Health Organization as seasonal malaria chemoprevention for children aged 3 to 59 months…”
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