Search Results - "David Goldstein"

The possible association between COVID-19 and postural tachycardia syndrome by Goldstein, David S.

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Common Genetic Variation and Human Traits by Goldstein, David B

“…Researchers now know how to properly account for most of the multiple hypothesis testing involved in mining the genome for associations, and most reported…”
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The extended autonomic system, dyshomeostasis, and COVID-19 by Goldstein, David S.

“…The pandemic viral illness COVID-19 is especially life-threatening in the elderly and in those with any of a variety of chronic medical conditions. This essay…”
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Genic intolerance to functional variation and the interpretation of personal genomes by Petrovski, Slavé, Wang, Quanli, Heinzen, Erin L, Allen, Andrew S, Goldstein, David B

“…A central challenge in interpreting personal genomes is determining which mutations most likely influence disease. Although progress has been made in scoring…”
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Drug development in the era of precision medicine by Dugger, Sarah A., Platt, Adam, Goldstein, David B.

“…Key Points Prior efforts using genomics to inform drug discovery (that is, expressed sequencing tag profiling and genome-wide association studies) have yielded…”
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How does homeostasis happen? Integrative physiological, systems biological, and evolutionary perspectives by Goldstein, David S

“…Homeostasis is a founding principle of integrative physiology. In current systems biology, however, homeostasis seems almost invisible. Is homeostasis a key…”
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The catecholaldehyde hypothesis: where MAO fits in by Goldstein, David S.

“…Monoamine oxidase (MAO) plays a central role in the metabolism of the neurotransmitters dopamine, norepinephrine, and serotonin. This brief review focuses on…”
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Rare variants create synthetic genome-wide associations by Dickson, Samuel P, Wang, Kai, Krantz, Ian, Hakonarson, Hakon, Goldstein, David B

“…Genome-wide association studies (GWAS) have now identified at least 2,000 common variants that appear associated with common diseases or related traits…”
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Post-COVID dysautonomias: what we know and (mainly) what we don’t know by Goldstein, David S.

“…Following on from the COVID-19 pandemic is another worldwide public health challenge that is referred to variously as long COVID, post-COVID syndrome or…”
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Extra-cranial cholinergic lesions in dementia with Lewy bodies by Goldstein, David S

“…This scientific commentary refers to ‘Impaired cholinergic integrity of the colon and pancreas in dementia with Lewy bodies’ by Okkels et al…”
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Is postural tachycardia syndrome a psychogenic disorder? by Goldstein, David S

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Enhancer Domains Predict Gene Pathogenicity and Inform Gene Discovery in Complex Disease by Wang, Xinchen, Goldstein, David B.

“…Non-coding transcriptional regulatory elements are critical for controlling the spatiotemporal expression of genes. Here, we demonstrate that the sizes and…”
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Uncovering the roles of rare variants in common disease through whole-genome sequencing by Goldstein, David B, Cirulli, Elizabeth T

“…Key Points Genome-wide association studies of very common variants have neither identified associations that explain a large portion of the heritability for…”
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Stress and the “extended” autonomic system by Goldstein, David S.

“…This review updates three key concepts of autonomic neuroscience—stress, the autonomic nervous system (ANS), and homeostasis. Hans Selye popularized stress as…”
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The Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Do Not Know by Goldstein, David S.

“…3,4-Dihydroxyphenylacetaldehyde (DOPAL) is the focus of the catecholaldehyde hypothesis for the pathogenesis of Parkinson’s disease and other Lewy body…”
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Unequal representation of genetic variation across ancestry groups creates healthcare inequality in the application of precision medicine by Petrovski, Slavé, Goldstein, David B

“…An important application of modern genomics is diagnosing genetic disorders. We use the largest publicly available exome sequence database to show that this…”
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Cardiovascular dysautonomia in Parkinson disease: From pathophysiology to pathogenesis by Jain, Samay, Goldstein, David S

“…Abstract Signs or symptoms of impaired autonomic regulation of circulation often attend Parkinson disease (PD). This review covers biomarkers and mechanisms of…”
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Adrenal Responses to Stress by Goldstein, David S

“…Based on concepts proposed by Langley, Cannon, and Selye, adrenal responses to stress occur in a syndrome that reflects activation of the sympathoadrenal…”
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The “All of Us” Research Program by Denny, Joshua C, Rutter, Joni L, Goldstein, David B, Philippakis, Anthony, Smoller, Jordan W, Jenkins, Gwynne, Dishman, Eric

“…The U.S. research cohort All of Us was announced in 2015 and launched last year. With more than one fifth of the target enrollment now completed, the…”
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Cerebrospinal fluid concentration gradients of catechols in synucleinopathies by Goldstein, David S., Sullivan, Patti, Holmes, Courtney

“…The synucleinopathies Parkinson disease (PD), multiple system atrophy (MSA), and the Lewy body form of pure autonomic failure (PAF) entail intra‐cytoplasmic…”
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