Search Results - "David Šmajs"

Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen by Radolf, Justin D., Deka, Ranjit K., Anand, Arvind, Šmajs, David, Norgard, Michael V., Yang, X. Frank

“…Key Points Pathogenic treponemes are clonal, unculturable, highly invasive bacteria that cause venereal syphilis, yaws, endemic syphilis and pinta —…”
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Treponema pallidum subsp. pallidum strains DAL-1 and Philadelphia 1 differ in generation times in vitro as well as during experimental rabbit infection by Bosák, Juraj, Mikalová, Lenka, Hrala, Matěj, Pospíšilová, Petra, Faldyna, Martin, Šmajs, David

“…In this work, we determined that Treponema pallidum subsp. pallidum (TPA) DAL-1 (belonging to Nichols-like group of TPA strains) grew 1.53 (± 0.08) times…”
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The Impact of DNA Extraction Methods on Stool Bacterial and Fungal Microbiota Community Recovery by Fiedorová, Kristýna, Radvanský, Matěj, Němcová, Eva, Grombiříková, Hana, Bosák, Juraj, Černochová, Michaela, Lexa, Matej, Šmajs, David, Freiberger, Tomáš

“…Our understanding of human gut microbiota in health and disease depends on accurate and reproducible microbial data acquisition. The critical step in this…”
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Molecular characterization of Treponema pallidum subsp. pallidum in Switzerland and France with a new multilocus sequence typing scheme by Grillová, Linda, Bawa, Tanika, Mikalová, Lenka, Gayet-Ageron, Angèle, Nieselt, Kay, Strouhal, Michal, Sednaoui, Patrice, Ferry, Tristan, Cavassini, Matthias, Lautenschlager, Stephan, Dutly, Fabrizio, Pla-Díaz, Marta, Krützen, Michael, González-Candelas, Fernando, Bagheri, Homayoun C, Šmajs, David, Arora, Natasha, Bosshard, Philipp P

“…Syphilis is an important public health problem and an increasing incidence has been noted in recent years. Characterization of strain diversity through…”
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High frequency of Nichols-like strains and increased levels of macrolide resistance in Treponema pallidum in clinical samples from Buenos Aires, Argentina by Morando, Nicolas, Vrbová, Eliška, Melgar, Asunta, Rabinovich, Roberto Daniel, Šmajs, David, Pando, María A.

“…Globally, 94% of Treponema pallidum subsp. pallidum (TPA) clinical strains belong to the SS14-like group and 6% to the Nichols-like group, with a prevalence of…”
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Sequence typing of Haemophilus ducreyi isolated from patients in the Namatanai region of Papua New Guinea: Infections by Class I and Class II strain types differ in ulcer duration and resurgence of infection after azithromycin treatment by Medappa, Monica, Pospíšilová, Petra, John, Lucy N, González-Beiras, Camila, Vall-Mayans, Marti, Mitjà, Oriol, Šmajs, David

“…Haemophilus ducreyi (HD) is an important cause of cutaneous ulcers in several endemic regions, including the Western Pacific Region, especially among children…”
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Majority of Treponema pallidum ssp. pallidum MLST allelic profiles in the Czech Republic (2004–2022) belong to two SS14-like clusters by Vrbová, Eliška, Pospíšilová, Petra, Dastychová, Eliška, Kojanová, Martina, Kreidlová, Miluše, Rob, Filip, Vašků, Vladimír, Mosio, Petra, Strnadel, Radim, Faustmannová, Olga, Kuklová, Ivana, Heroldová, Monika Dvořáková, Zákoucká, Hana, Šmajs, David

“…Syphilis is a multistage sexually transmitted disease caused by Treponema pallidum ssp. pallidum . In the Czech Republic, there are around 700–800 new syphilis…”
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The hare syphilis agent is related to, but distinct from, the treponeme causing rabbit syphilis by Pospíšilová, Petra, Čejková, Darina, Buršíková, Pavla, Fedrová, Pavla, Mikalová, Lenka, Najt, David, Tom, Nikola, Hisgen, Linda, Lueert, Simone, Lumeij, Johannes T, Ågren, Erik O, Knauf, Sascha, Šmajs, David

“…The treponemes infecting lagomorphs include Treponema paraluisleporidarum ecovar Cuniculus (TPeC) and ecovar Lepus (TPeL), infecting rabbits and hares,…”
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Escherichia coli Strains Producing Selected Bacteriocins Inhibit Porcine Enterotoxigenic Escherichia coli (ETEC) under both In Vitro and In Vivo Conditions by Hrala, Matěj, Bosák, Juraj, Micenková, Lenka, Křenová, Jitka, Lexa, Matej, Pirková, Viktória, Tomáštíková, Zuzana, Koláčková, Ivana, Šmajs, David

“…Enterotoxigenic Escherichia coli (ETEC) and Shiga toxin-producing E. coli (STEC) strains are the causative agents of severe foodborne diseases in both humans…”
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Analysis of Treponema pallidum Strains From China Using Improved Methods for Whole-Genome Sequencing From Primary Syphilis Chancres by Chen, Wentao, Šmajs, David, Hu, Yongfei, Ke, Wujian, Pospíšilová, Petra, Hawley, Kelly L, Caimano, Melissa J, Radolf, Justin D, Sena, Arlene, Tucker, Joseph D, Yang, Bin, Juliano, Jonathan J, Zheng, Heping, Parr, Jonathan B

“…Abstract Background Whole-genome sequencing (WGS) of Treponema pallidum subspecies pallidum (TPA) has been constrained by the lack of in vitro cultivation…”
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The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct by Janecková, Klára, Roos, Christian, Fedrová, Pavla, Tom, Nikola, Cejková, Darina, Lueert, Simone, Keyyu, Julius D, Chuma, Idrissa S, Knauf, Sascha, Smajs, David

“…Background Treponema pallidum subsp. pertenue ( TPE ) is the causative agent of human yaws. Yaws is currently reported in 13 endemic countries in Africa,…”
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Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients' ulcers in Namatanai District of Papua New Guinea: Local human population is infected by three TPE genotypes by Medappa, Monica, Pospíšilová, Petra, Madruga, Maria Paula M, John, Lucy N, Beiras, Camila G, Grillová, Linda, Oppelt, Jan, Banerjee, Arka, Vall-Mayans, Marti, Mitjà, Oriol, Šmajs, David

“…Yaws is an endemic disease caused by Treponema pallidum subsp. pertenue (TPE) that primarily affects children in rural regions of the tropics. The endemic…”
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Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters by Pětrošová, Helena, Pospíšilová, Petra, Strouhal, Michal, Čejková, Darina, Zobaníková, Marie, Mikalová, Lenka, Sodergren, Erica, Weinstock, George M, Šmajs, David

“…Treponema pallidum ssp. pallidum (TPA), the causative agent of syphilis, is a highly clonal bacterium showing minimal genetic variability in the genome…”
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Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively by Mikalová, Lenka, Strouhal, Michal, Oppelt, Jan, Grange, Philippe Alain, Janier, Michel, Benhaddou, Nadjet, Dupin, Nicolas, Šmajs, David

“…Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a…”
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Whole genome sequences of Treponema pallidum subsp. endemicum isolated from Cuban patients: The non-clonal character of isolates suggests a persistent human infection rather than a single outbreak by Vrbová, Eliška, Noda, Angel A, Grillová, Linda, Rodríguez, Islay, Forsyth, Allyn, Oppelt, Jan, Šmajs, David

“…Bejel (endemic syphilis) is a neglected non-venereal disease caused by Treponema pallidum subsp. endemicum (TEN). Although it is mostly present in hot, dry…”
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Molecular typing of Treponema pallidum isolates from Buenos Aires, Argentina: Frequent Nichols-like isolates and low levels of macrolide resistance by Gallo Vaulet, Lucía, Grillová, Linda, Mikalová, Lenka, Casco, Ricardo, Rodríguez Fermepin, Marcelo, Pando, María A, Šmajs, David

“…A total of 54 clinical samples, including genital lesion swabs, whole blood and cerebrospinal fluid from patients diagnosed with syphilis were collected in…”
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R-Type Fonticins Produced by Pragia fontium Form Large Pores with High Conductance by Látrová, Klára, Dolejšová, Tereza, Motlová, Lucia, Mikušová, Gabriela, Bosák, Juraj, Snopková, Kateřina, Šmajs, David, Konopásek, Ivo, Fišer, Radovan

“…Fonticins are phage tail-like bacteriocins produced by the Gram-negative bacterium Pragia fontium from the family . This bacterium produces contractile-type…”
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Patients With Common Variable Immunodeficiency (CVID) Show Higher Gut Bacterial Diversity and Levels of Low-Abundance Genes Than the Healthy Housemates by Bosák, Juraj, Lexa, Matej, Fiedorová, Kristýna, Gadara, Darshak C., Micenková, Lenka, Spacil, Zdenek, Litzman, Jiří, Freiberger, Tomáš, Šmajs, David

“…Common variable immunodeficiency (CVID) is a clinically and genetically heterogeneous disorder with inadequate antibody responses and low levels of…”
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Whole genome sequence of the Treponema pallidum subsp. endemicum strain Iraq B: A subpopulation of bejel treponemes contains full-length tprF and tprG genes similar to those present in T. p. subsp. pertenue strains by Mikalová, Lenka, Janečková, Klára, Nováková, Markéta, Strouhal, Michal, Čejková, Darina, Harper, Kristin N, Šmajs, David

“…Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). Until now, only a single TEN strain, Bosnia A, has been…”
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Molecular Typing of Syphilis-Causing Strains Among Human Immunodeficiency Virus-Positive Patients in Antwerp, Belgium by Mikalová, Lenka, Grillová, Linda, Osbak, Kara, Strouhal, Michal, Kenyon, Chris, Crucitti, Tania, Šmajs, David

“…Centers for Disease Control and Prevention and sequencingbased treponeme typing was used to analyze 72 blood samples, collected from human immunodeficiency…”
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