Search Results - "David‐Habiel"

Quercetin Enhances Ligand-induced Apoptosis in Senescent Idiopathic Pulmonary Fibrosis Fibroblasts and Reduces Lung Fibrosis In Vivo by Hohmann, Miriam S, Habiel, David M, Coelho, Ana L, Verri, Jr, Waldiceu A, Hogaboam, Cory M

“…Although cellular senescence may be a protective mechanism in modulating proliferative capacity, fibroblast senescence is now recognized as a key pathogenic…”
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Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis by Espindola, Milena S, Habiel, David M, Narayanan, Rohan, Jones, Isabelle, Coelho, Ana L, Murray, Lynne A, Jiang, Dianhua, Noble, Paul W, Hogaboam, Cory M

“…Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant lung remodeling, which progressively abolishes lung function in an RTK (receptor tyrosine…”
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Heterogeneity in fibroblast proliferation and survival in idiopathic pulmonary fibrosis by Habiel, David M, Hogaboam, Cory

“…Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease characterized by the persistence of activated myofibroblasts resulting…”
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Heterogeneity of Fibroblasts and Myofibroblasts in Pulmonary Fibrosis by Habiel, David M., Hogaboam, Cory M.

“…Purpose of Review Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease of unknown etiopathogenesis with mean survival of…”
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Differential Responses to Targeting Matrix Metalloproteinase 9 in Idiopathic Pulmonary Fibrosis by Espindola, Milena S, Habiel, David M, Coelho, Ana Lucia, Stripp, Barry, Parks, William C, Oldham, Justin, Martinez, Fernando J, Noth, Imre, Lopez, David, Mikels-Vigdal, Amanda, Smith, Victoria, Hogaboam, Cory M

“…Aberrant lung remodeling in idiopathic pulmonary fibrosis (IPF) is characterized by elevated MMP9 (matrix metalloproteinase 9) expression, but the precise role…”
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Modeling Idiopathic Pulmonary Fibrosis in Humanized Severe Combined Immunodeficient Mice by Habiel, David M., Espindola, Milena S., Coelho, Ana L., Hogaboam, Cory M.

“…Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease of unknown etiopathogenesis with limited therapeutic options. IPF is characterized by an…”
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The IKKα-dependent NF-κB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1 by Kew, Richard R, Penzo, Marianna, Habiel, David M, Marcu, Kenneth B

“…HMGB1 is a chromatin architectural protein that is released by dead or damaged cells at sites of tissue injury. Extracellular HMGB1 functions as a…”
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Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine by Hartl, Dominik, Tirouvanziam, Rabindra, Laval, Julie, Greene, Catherine M., Habiel, David, Sharma, Lokesh, Yildirim, Ali Önder, Dela Cruz, Charles S., Hogaboam, Cory M.

“…The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune…”
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Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism by Parathath, Sajesh, Mick, Stephanie L, Feig, Jonathan E, Joaquin, Victor, Grauer, Lisa, Habiel, David M, Gassmann, Max, Gardner, Lawrence B, Fisher, Edward A

“…RATIONALE:Human atherosclerotic plaques contain large numbers of cells deprived of O2. In murine atherosclerosis, because the plaques are small, it is…”
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Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes by Parimon, Tanyalak, Brauer, Rena, Schlesinger, Saundra Y., Xie, Ting, Jiang, Dianhua, Ge, Lingyin, Huang, Ying, Birkland, Timothy P., Parks, William C., Habiel, David M., Hogaboam, Cory M., Gharib, Sina A., Deng, Nan, Liu, Zhenqui, Chen, Peter

“…Syndecan-1 is a transmembrane proteoglycan expressed prominently by lung epithelium and has pleiotropic functions such as regulating cell migration,…”
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Reply to D'Alessandro-Gabazza et al.: Risks of Treating Idiopathic Pulmonary Fibrosis with a TAM Receptor Kinase Inhibitor by Espindola, Milena S, Habiel, David M, Hogaboam, Cory M

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Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma by Shibata, Takehiko, Habiel, David M, Coelho, Ana L, Kunkel, Steven L, Lukacs, Nicholas W, Hogaboam, Cory M

“…Viruses use Tyro3, Axl, and Mertk (TAM) receptor tyrosine kinases to infect and modulate the immune properties of various cell types, which led us to…”
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Inhibition of the stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease by Rasky, Andrew, Habiel, David M, Morris, Susan, Schaller, Matthew, Moore, Bethany B, Phan, Sem, Kunkel, Steven L, Phillips, Martin, Hogaboam, Cory, Lukacs, Nicholas W

“…Stem cell factor (SCF) and its receptor c-kit have been implicated in inflammation, tissue remodeling, and fibrosis. Ingenuity Integrated Pathway Analysis of…”
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Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice by Trujillo, Glenda, Habiel, David M, Ge, Lingyin, Ramadass, Mahalakshmi, Cooke, Nancy E, Kew, Richard R

“…Knowledge of how neutrophils respond to chemotactic signals in a complex inflammatory environment is not completely understood. Moreover, even less is known…”
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PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis by Geng, Yan, Liu, Xue, Liang, Jiurong, Habiel, David M, Kulur, Vrishika, Coelho, Ana Lucia, Deng, Nan, Xie, Ting, Wang, Yizhou, Liu, Ningshan, Huang, Guanling, Kurkciyan, Adrianne, Liu, Zhenqiu, Tang, Jie, Hogaboam, Cory M, Jiang, Dianhua, Noble, Paul W

“…Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unremitting extracellular matrix deposition, leading to a distortion of pulmonary…”
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Divergent roles for Clusterin in Lung Injury and Repair by Habiel, David M., Camelo, Ana, Espindola, Milena, Burwell, Timothy, Hanna, Richard, Miranda, Elena, Carruthers, Alan, Bell, Matthew, Coelho, Ana Lucia, Liu, Hao, Pilataxi, Fernanda, Clarke, Lori, Grant, Ethan, Lewis, Arthur, Moore, Bethany, Knight, Darryl A., Hogaboam, Cory M., Murray, Lynne A.

“…Lung fibrosis is an unabated wound healing response characterized by the loss and aberrant function of lung epithelial cells. Herein, we report that…”
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Axl receptor blockade protects from invasive pulmonary aspergillosis in mice by Shibata, Takehiko, Habiel, David M, Coelho, Ana Lucia, Hogaboam, Cory M

“…Aspergillus fumigatus is a sporulating fungus found ubiquitously in the environment, which is quickly contained in the immunocompetent host but can cause…”
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Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium by Murray, Lynne A, Dunmore, Rebecca, Camelo, Ana, Da Silva, Carla A, Gustavsson, Malin J, Habiel, David M, Hackett, Tillie L, Hogaboam, Cory M, Sleeman, Matthew A, Knight, Darryl A

“…Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis…”
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Targeting MAP3K19 prevents human lung myofibroblast activation both in vitro and in a humanized SCID model of idiopathic pulmonary fibrosis by Jones, Isabelle C., Espindola, Milena S., Narayanan, Rohan, Coelho, Ana L., Habiel, David M., Boehme, Stefen A., Ly, Tai Wei, Bacon, Kevin B., Hogaboam, Cory M.

“…Idiopathic Pulmonary Fibrosis (IPF) is a disease with a devastating prognosis characterized by unrelenting lung scarring. Aberrant activation of lung…”
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DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis by Habiel, David M, Hohmann, Miriam S, Espindola, Milena S, Coelho, Ana Lucia, Jones, Isabelle, Jones, Heather, Carnibella, Richard, Pinar, Isaac, Werdiger, Freda, Hogaboam, Cory M

“…Recent studies have highlighted the contribution of senescent mesenchymal and epithelial cells in Idiopathic Pulmonary Fibrosis (IPF), but little is known…”
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