Search Results - "David, Wyatt"

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks by Wyatt, David W., Feng, Wanjuan, Conlin, Michael P., Yousefzadeh, Matthew J., Roberts, Steven A., Mieczkowski, Piotr, Wood, Richard D., Gupta, Gaorav P., Ramsden, Dale A.

“…DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) has been implicated in the repair of chromosome breaks, but its cellular mechanism and role relative…”
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Mechanism of suppression of chromosomal instability by DNA polymerase POLQ by Yousefzadeh, Matthew J, Wyatt, David W, Takata, Kei-Ichi, Mu, Yunxiang, Hensley, Sean C, Tomida, Junya, Bylund, Göran O, Doublié, Sylvie, Johansson, Erik, Ramsden, Dale A, McBride, Kevin M, Wood, Richard D

“…Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been…”
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Clinical and socioeconomic predictors of hospital use and emergency department visits among children with medical complexity: A machine learning approach using administrative data by Sidra, Michael, Pietrosanu, Matthew, Zwicker, Jennifer, Johnson, David Wyatt, Round, Jeff, Ohinmaa, Arto

“…The primary objective of this study was to identify clinical and socioeconomic predictors of hospital and ED use among children with medical complexity within…”
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The impact of road grade on carbon dioxide (CO2) emission of a passenger vehicle in real-world driving by Wyatt, David W., Li, Hu, Tate, James E.

“…•A simple LiDAR-GIS methodology introduced to establish second-by-second road grade.•PEMS CO2 emission analysis of micro-scale sections in an urban traffic…”
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A Phase I, Open-label, Randomized, 2-Way Crossover Study to Evaluate the Relative Bioavailability of Intranasal and Oral Varenicline by Nau, Jeffrey, Wyatt, David J., Rollema, Hans, Crean, Christopher S.

“…To estimate the systemic bioavailability of OC-01 (varenicline) nasal spray, an investigational treatment for dry eye disease, relative to oral varenicline…”
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TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A by Ma, X. Rosa, Prudencio, Mercedes, Koike, Yuka, Vatsavayai, Sarat C., Kim, Garam, Harbinski, Fred, Briner, Adam, Rodriguez, Caitlin M., Guo, Caiwei, Akiyama, Tetsuya, Schmidt, H. Broder, Cummings, Beryl B., Wyatt, David W., Kurylo, Katherine, Miller, Georgiana, Mekhoubad, Shila, Sallee, Nathan, Mekonnen, Gemechu, Ganser, Laura, Rubien, Jack D., Jansen-West, Karen, Cook, Casey N., Pickles, Sarah, Oskarsson, Björn, Graff-Radford, Neill R., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Dickson, Dennis W., Shorter, James, Myong, Sua, Green, Eric M., Seeley, William W., Petrucelli, Leonard, Gitler, Aaron D.

“…A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of…”
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Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets by Karimy, Jason K., Reeves, Benjamin C., Damisah, Eyiyemisi, Duy, Phan Q., Antwi, Prince, David, Wyatt, Wang, Kevin, Schiff, Steven J., Limbrick, David D., Alper, Seth L., Warf , Benjamin C., Nedergaard, Maiken, Simard, J. Marc, Kahle, Kristopher T.

“…Hydrocephalus is the most common neurosurgical disorder worldwide and is characterized by enlargement of the cerebrospinal fluid (CSF)-filled brain ventricles…”
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Nonhomologous end joining: A good solution for bad ends by Waters, Crystal A., Strande, Natasha T., Wyatt, David W., Pryor, John M., Ramsden, Dale A.

“…•We review here how diverse ends at chromosome breaks are resolved by NHEJ.•We summarize structures, interactions, and activities of factors implicated in…”
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Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation by Duy, Phan Q, David, Wyatt B, Kahle, Kristopher T

“…Epilepsy is a common neurological disorder characterized by recurrent and unprovoked seizures thought to arise from impaired balance between neuronal…”
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Impacts of COVID-19 on clinical research in the UK: A multi-method qualitative case study by Wyatt, David, Faulkner-Gurstein, Rachel, Cowan, Hannah, Wolfe, Charles D. A

“…Background Clinical research has been central to the global response to COVID-19, and the United Kingdom (UK), with its research system embedded within the…”
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Hospital Consumer Assessment of Healthcare Providers and Systems survey response rates are significantly affected by patient characteristics and postoperative outcomes for patients undergoing primary total knee arthroplasty by Mercier, Michael R, Galivanche, Anoop R, David, Wyatt B, Malpani, Rohil, Pathak, Neil, Hilibrand, Ari S, Rubin, Lee E, Grauer, Jonathan N

“…Introduction The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey measures patients’ satisfaction of their hospital experience…”
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Adaptive Prognostic Malfunction Based Processor for Autonomous Landing Guidance Assistance System Using FPGA by Ahmed, Hossam O., Wyatt, David

“…The demand for more developed and agile urban taxi drones is increasing rapidly nowadays to sustain crowded cities and their traffic issues. The critical…”
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Evaluating the role of amino acids and isothermal dry particle coating in modulating buccal permeation of large molecule drug vancomycin by Rajabi, Anthony, Idrees, Muhammed, Rahman, Ayesha, Iyire, Affiong, Wyatt, David, Koner, Jasdip, Mohammed, Afzal R.

“…The formulation and delivery of macromolecules through the oral route pose considerable challenges due to factors such as large molecular weight, pH…”
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Stepwise requirements for polymerases δ and θ in theta-mediated end joining by Stroik, Susanna, Carvajal-Garcia, Juan, Gupta, Dipika, Edwards, Alyssa, Luthman, Adam, Wyatt, David W., Dannenberg, Rachel L., Feng, Wanjuan, Kunkel, Thomas A., Gupta, Gaorav P., Hedglin, Mark, Wood, Richard, Doublié, Sylvie, Rothenberg, Eli, Ramsden, Dale A.

“…Timely repair of chromosomal double-strand breaks is required for genome integrity and cellular viability. The polymerase theta-mediated end joining pathway…”
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Extent of resection of epidermoid tumors and risk of recurrence: case report and meta-analysis by Shear, Brian M, Jin, Lan, Zhang, Yawei, David, Wyatt B, Fomchenko, Elena I, Erson-Omay, E Zeynep, Huttner, Anita, Fulbright, Robert K, Moliterno, Jennifer

“…Intracranial epidermoid tumors are slow-growing, histologically benign tumors of epithelial cellular origin that can be symptomatic because of their size and…”
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Portending Influence Racial Disparities has on Extended Length of Stay after Elective Anterior Cervical Discectomy and Interbody Fusion for Cervical Spondylotic Myelopathy by Elsamadicy, Aladine A, Koo, Andrew B, David, Wyatt, Sarkozy, Margot, Freedman, Isaac G, Reeves, Benjamin, Laurans, Maxwell, Kolb, Luis, Sciubba, Daniel M

“…INTRODUCTION Despite recent progress towards equitable and unbiased healthcare delivery, previous studies exploring anterior cervical discectomy and fusion…”
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Race and All-cause Mortality in Patients with a Primary Malignant or Nonmalignant Tumor of the Spinal Cord or Spinal Meninges: A Propensity-score Analysis by Elsamadicy, Aladine A, Freedman, Isaac G, Koo, Andrew B, David, Wyatt, Reeves, Benjamin, Antonios, Joseph P, Laurans, Maxwell, Kolb, Luis, Sciubba, Daniel M

“…INTRODUCTION Previous studies have demonstrated that non-white race is associated with inferior outcomes for patients with neurological, spinal, and other…”
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Differences in Outcomes and Health Care Resource Utilization After Surgical Intervention for Metastatic Spinal Column Tumor in Safety-Net Hospitals by Elsamadicy, Aladine A., Koo, Andrew B., David, Wyatt B., Reeves, Benjamin C., Sherman, Josiah J.Z., Craft, Samuel, Hersh, Andrew M., Duvall, Julia, Lo, Sheng-Fu Larry, Shin, John H., Mendel, Ehud, Sciubba, Daniel M.

“…Observational cohort study. The aim of this study was to investigate the association between safety-net hospital (SNH) status and hospital length of stay…”
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Modified-frailty index does not independently predict complications, hospital length of stay or 30-day readmission rates following posterior lumbar decompression and fusion for spondylolisthesis by Elsamadicy, Aladine A., Freedman, Isaac G., Koo, Andrew B., David, Wyatt B, Reeves, Benjamin C., Havlik, John, Pennington, Zach, Kolb, Luis, Shin, John H., Sciubba, Daniel M.

“…Frailty has been associated with inferior surgical outcomes in various fields of spinal surgery. With increasing healthcare costs, hospital length of stay…”
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Thirty- and 90-day Readmissions After Spinal Surgery for Spine Metastases: A National Trend Analysis of 4423 Patients by Elsamadicy, Aladine A., Koo, Andrew B., David, Wyatt B., Zogg, Cheryl K., Kundishora, Adam J., Hong, Christopher S., Kuzmik, Gregory A., Gorrepati, Ramana, Coutinho, Pedro O., Kolb, Luis, Laurans, Maxwell, Abbed, Khalid

“…Retrospective cohort study. The aim of this study was to investigate differences in 30- and 90-day readmissions for spine metastases treated with decompression…”
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