Search Results - "David, T.E"

Hemodilution during cardiopulmonary bypass is an independent risk factor for acute renal failure in adult cardiac surgery by Karkouti, K., Beattie, W.S., Wijeysundera, D.N., Rao, V., Chan, C., Dattilo, K.M., Djaiani, G., Ivanov, J., Karski, J., David, T.E.

“…This observational study sought to determine whether the degree of hemodilution during cardiopulmonary bypass is independently related to perioperative acute…”
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DAVID VS. GOLIATH: VALVE-SPARING ROOT REPLACEMENT IMPROVES Outcomes COMPARED TO BENTALL PROCEDURES IN PATIENTS WITH AORTIC ROOT DILATATION by Ouzounian, M, Rao, V, Manlhiot, C, Abraham, N, David, C, Feindel, C.M, David, T.E

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PROGRESSIVE AORTIC DILATATION IS REGULATED BY THE MIR-17 CLUSTER by Wu, J, Guo, J, Li, S, Tsang, K, Tumiati, L, David, C, Bos, J, Ouzounian, M, Yau, T.M, David, T.E, Weisel, R.D, Li, R

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Experimental measurements of zebra mussel (Dreissena polymorpha) impacts on phytoplankton community composition by Bastviken, David T.E, Caraco, Nina F, Cole, Jonathan J

“…1. To investigate direct effects of zebra mussel (Dreissena polymorpha) feeding activities on phytoplankton community composition, short-term microcosm…”
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Radical cyclisations promoted by dimanganese decacarbonyl: A new and flexible approach to 5-membered N-heterocycles by Gilbert, Bruce C., Kalz, Wilhelm, Lindsay, Chris I., McGrail, P.Terry, Parsons, Andrew F., Whittaker, David T.E.

“…Radical cyclisation of various unsaturated halides using dimanganese decacarbonyl/ hv has been explored. Substituted pyrrolidinones and a pyrrolidine were…”
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Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction by Graham, Mark A., Noonan, Gary, Cherryman, Janette H., Douglas, James J., Gonzalez, Miguel, Jackson, Lucinda V., Leslie, Kevin, Liu, Zhi-qing, McKinney, David, Munday, Rachel H., Parsons, Chris D., Whittaker, David T. E., Zhang, En-xuan, Zhang, Jun-wang

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Investigating the Activation Kinetics of Phosphoramidites for Oligonucleotide Synthesis by Laraman, Fiona J, Fisk, Heidi, Whittaker, David T. E, Cherryman, Janette H, Diorazio, Louis J

“…Solid-phase synthesis of oligonucleotides relies on a repeating cycle of rapid and well-defined synthetic steps to generate the target sequence. It is…”
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NMR and Thermal Studies for the Characterization of Mass Transport and Phase Separation in Paracetamol/Copovidone Hot-Melt Extrusion Formulations by Pisa, Elena, Hughes, Leslie P, Wren, Stephen A C, Booth, Jonathan, McCabe, James Francis, Whittaker, David T E, Mantle, Mick D

“…The formulation of drug/polymer amorphous solid dispersions (ASDs) is one of the most successful strategies for improving the oral bioavailability of poorly…”
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Monitoring apoptosis in intact cells by high‐resolution magic angle spinning 1H NMR spectroscopy by Wylot, Marta, Whittaker, David T.E., Wren, Stephen A.C., Bothwell, John H., Hughes, Leslie, Griffin, Julian L.

“…Apoptosis maintains an equilibrium between cell proliferation and cell death. Many diseases, including cancer, develop because of defects in apoptosis. A known…”
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Monitoring apoptosis in intact cells by high-resolution magic angle spinning 1 H NMR spectroscopy by Wylot, Marta, Whittaker, David T E, Wren, Stephen A C, Bothwell, John H, Hughes, Leslie, Griffin, Julian L

“…Apoptosis maintains an equilibrium between cell proliferation and cell death. Many diseases, including cancer, develop because of defects in apoptosis. A known…”
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Process Development of a Suzuki Reaction Used in the Manufacture of Lanabecestat by Ashworth, Ian W, Campbell, Andrew D, Cherryman, Janette H, Clark, Jemma, Crampton, Alex, Eden-Rump, Edward G. B, Evans, Matthew, Jones, Martin F, McKeever-Abbas, Sahar, Meadows, Rebecca E, Skilling, Kathryn, Whittaker, David T. E, Woodward, Robert L, Inglesby, Phillip A

“…We developed a scalable Suzuki process for the synthesis of lanabecestat (+)-camsylate, an active pharmaceutical ingredient that was recently investigated in a…”
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LONG-TERM OUTCOMES OF THE ROSS PROCEDURE VERSUS MECHANICAL AORTIC VALVE REPLACEMENT: A PROPENSITY-MATCHED COHORT STUDY by Mazine, A, David, T.E, Rao, V, Hickey, E.J, Christie, S, Manlhiot, C, Ouzounian, M

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An efficient one-pot synthesis of 2-bromo-6-aryl[5H]pyrrolo[2,3-b]pyrazines by Simpson, Iain, St-Gallay, Steve A., Stokes, Stephen, Whittaker, David T.E., Wiewiora, Rafal

“…[Display omitted] We report a two step one-pot method for the synthesis of 2-bromo-6-aryl[5H]pyrrolo[2,3-b]pyrazines. The process makes use of a cleaner…”
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Long-term results of surgery for active infective endocarditis1 by d'Udekem, Y, David, T.E, Feindel, C.M, Armstrong, S, Sun, Z

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068TWENTY-YEAR DURABILITY OF THE AORTIC HANCOCK II BIOPROSTHESIS IN YOUNG PATIENTS: IS IT DURABLE ENOUGH? by Une, D., Armstrong, S., Ruel, M., David, T.E.

“…Objectives: The Hancock II bioprosthesis has been reported to have excellent durability in patients ≥60 years of age. This study examined the long-term…”
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Asymmetric deprotonation of N-Boc-piperidines by Coldham, Iain, O’Brien, Peter, Patel, Jignesh J., Raimbault, Sophie, Sanderson, Adam J., Stead, Darren, Whittaker, David T.E.

“…A selection of chiral ligands was screened for the asymmetric deprotonation of N-Boc-piperidine. The asymmetric deprotonation of this compound is notoriously…”
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LONG-TERM OUTCOMES OF THE ROSS PROCEDURE VERSUS MECHANICAL AORTIC VALVE REPLACEMENT: A PROPENSITY-MATCHED COHORT STUDY by Mazine, A., David, T.E., Rao, V., Hickey, E.J., Christie, S., Manlhiot, C., Ouzounian, M.

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Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine by Coldham, Iain, Patel, Jignesh J, Raimbault, Sophie, Whittaker, David T E

“…Asymmetric substitution of 2-lithiopiperidines can be achieved by dynamic resolution; the organolithium is formed as a racemic mixture by proton abstraction…”
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Efficient Radical Coupling of Organobromides Using Dimanganese Decacarbonyl by Gilbert, Bruce C., Lindsay, Chris I., McGrail, P. Terry, Parsons, Andrew F., Whittaker, David T. E.

“…Wurtz-type radical coupling of a variety of allylic and benzylic bromides was observed on irradiation with dimanganese decacarbonyl in excellent yield…”
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Myocardial infarction determined by technetium-99m pyrophosphate single-photon tomography complicating elective coronary artery bypass grafting for angina pectoris by Burns, Robert J., Gladstone, Peter J., Tremblay, Paul C., Feindel, Christopher M., Salter, David R., Lipton, Irving H., Ogilvie, Raymond R., David, Tirone E.

“…The incidence of acute myocardial infarction (AMI) complicating coronary artery bypass grafting (CABG) has previously been based on concordance of…”
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