Search Results - "David, Sascha"

First do no harm-beware the risk of therapeutic plasma exchange in severe COVID-19 by Stahl, Klaus, Bode, Christian, David, Sascha

“…TPE carries a category 3 recommendation for sepsis with multiple organ failure in the 2019 American Society for Apheresis guidelines [10], stating…”
Get full text

Letter to the Editor: Innovative future concepts of extracorporeal strategies in sepsis and septic shock by Stahl, Klaus, Bode, Christian, David, Sascha

“…[...]the negative high-quality data from both the COMPACT-2 (unselective removal using high volume coupled plasma filtration and adsorption (CPFA)) and the…”
Get full text

From Angiopoietin-2 to basic chemistry: differential effects of statins on endothelial homeostasis in ARDS by Hofmaenner, Daniel A, David, Sascha

“…[...]low cholesterol levels have long been recognized to be associated with worse patient outcomes in sepsis and ARDS [4]. [...]ARDS is a syndrome known to be…”
Get full text

Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers by Knaup, Hannah, Stahl, Klaus, Schmidt, Bernhard M W, Idowu, Temitayo O, Busch, Markus, Wiesner, Olaf, Welte, Tobias, Haller, Hermann, Kielstein, Jan T, Hoeper, Marius M, David, Sascha

“…Given the pathophysiological key role of the host response to an infection rather than the infection per se, an ideal therapeutic strategy would also target…”
Get full text

Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years by Schmidt, Julius J, Lueck, Catherina, Ziesing, Stefan, Stoll, Matthias, Haller, Hermann, Gottlieb, Jens, Eder, Matthias, Welte, Tobias, Hoeper, Marius M, Scherag, André, David, Sascha

“…Despite modern intensive care with standardized strategies against acute respiratory distress syndrome (ARDS), Pneumocystis pneumonia (PcP) remains a…”
Get full text

Introductory editorial for the thematic collection “blood purification in sepsis: from bench to bedside” in intensive care medicine experimental by Stahl, Klaus, David, Sascha

Get full text

Endothelial‐to‐mesenchymal transition shapes the atherosclerotic plaque and modulates macrophage function by Helmke, Alexandra, Casper, Janis, Nordlohne, Johannes, David, Sascha, Haller, Hermann, Zeisberg, Elisabeth M., Vietinghoff, Sibylle

“…ABSTRACT Endothelial cells can acquire a mesenchymal phenotype upon irritation [endothelial‐to‐mesenchymal transition (EndMT)]. Macrophages accumulate in the…”
Get full text

Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome by Wendel-Garcia, Pedro David, Erlebach, Rolf, Hofmaenner, Daniel Andrea, Camen, Giovanni, Schuepbach, Reto Andreas, Jüngst, Christoph, Müllhaupt, Beat, Bartussek, Jan, Buehler, Philipp Karl, Andermatt, Rea, David, Sascha

“…A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the…”
Get full text

Effect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock by Stahl, Klaus, Schmidt, Julius J, Seeliger, Benjamin, Schmidt, Bernhard M W, Welte, Tobias, Haller, Hermann, Hoeper, Marius M, Budde, Ulrich, Bode, Christian, David, Sascha

“…A dysbalanced coagulation system is part of the pathological host response to infection in sepsis. Activation of pro-coagulant pathways and attenuation of…”
Get full text

Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome by Seeliger, Benjamin, Doebler, Michael, Hofmaenner, Daniel Andrea, Wendel-Garcia, Pedro D., Schuepbach, Reto A., Schmidt, Julius J., Welte, Tobias, Hoeper, Marius M., Gillmann, Hans-Jörg, Kuehn, Christian, Ehrentraut, Stefan Felix, Schewe, Jens-Christian, Putensen, Christian, Stahl, Klaus, Bode, Christian, David, Sascha

“…Extracorporeal membrane oxygenation (ECMO) is a potentially lifesaving procedure in acute respiratory distress syndrome (ARDS) due to COVID-19. Previous…”
Get full text

"Better be awake"-a role for awake extracorporeal membrane oxygenation in acute respiratory distress syndrome due to Pneumocystis pneumonia by Stahl, Klaus, Seeliger, Benjamin, Hoeper, Marius M, David, Sascha

“…Availability of data and materials Not applicable…”
Get full text

Comparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure by Seeliger, Benjamin, Döbler, Michael, Friedrich, Robert, Stahl, Klaus, Kühn, Christian, Bauersachs, Johann, Steinhagen, Folkert, Ehrentraut, Stefan F, Schewe, Jens-Christian, Putensen, Christian, Welte, Tobias, Hoeper, Marius M, Tiede, Andreas, David, Sascha, Bode, Christian

“…Extracorporeal membrane oxygenation (ECMO) support in acute respiratory failure may be lifesaving, but bleeding and thromboembolic complications are common…”
Get full text

Extracorporeal membrane oxygenation in non-intubated immunocompromised patients by Stahl, Klaus, Schenk, Heiko, Kühn, Christian, Wiesner, Olaf, Hoeper, Marius M, David, Sascha

“…Ventilator-induced lung injury, ventilator-acquired pneumonia and ventilator-induced diaphragm dysfunction are severe side effects of invasive ventilation and…”
Get full text

Reappearance of effector T cells is associated with recovery from COVID-19 by Odak, Ivan, Barros-Martins, Joana, Bošnjak, Berislav, Stahl, Klaus, David, Sascha, Wiesner, Olaf, Busch, Markus, Hoeper, Marius M., Pink, Isabell, Welte, Tobias, Cornberg, Markus, Stoll, Matthias, Goudeva, Lilia, Blasczyk, Rainer, Ganser, Arnold, Prinz, Immo, Förster, Reinhold, Koenecke, Christian, Schultze-Florey, Christian R.

“…Elucidating the role of T cell responses in COVID-19 is of utmost importance to understand the clearance of SARS-CoV-2 infection. 30 hospitalized COVID-19…”
Get full text

Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening by Ioannou, Marianna, Hoving, Dennis, Aramburu, Iker Valle, Temkin, Mia I., De Vasconcelos, Nathalia M., Tsourouktsoglou, Theodora-Dorita, Wang, Qian, Boeing, Stefan, Goldstone, Robert, Vernardis, Spyros, Demichev, Vadim, Ralser, Markus, David, Sascha, Stahl, Klaus, Bode, Christian, Papayannopoulos, Venizelos

“…The mechanisms linking systemic infection to hyperinflammation and immune dysfunction in sepsis are poorly understood. Extracellular histones promote sepsis…”
Get full text

Clinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial by Stahl, Klaus, Wand, Philipp, Seeliger, Benjamin, Wendel-Garcia, Pedro David, Schmidt, Julius J, Schmidt, Bernhard M W, Sauer, Andrea, Lehmann, Felix, Budde, Ulrich, Busch, Markus, Wiesner, Olaf, Welte, Tobias, Haller, Hermann, Wedemeyer, Heiner, Putensen, Christian, Hoeper, Marius M, Bode, Christian, David, Sascha

“…Recently, a randomized controlled trial (RCT) demonstrated rapid but individually variable hemodynamic improvement with therapeutic plasma exchange (TPE) in…”
Get full text

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis by David, Sascha, Mukherjee, Aditi, Ghosh, Chandra C, Yano, Midori, Khankin, Eliyahu V, Wenger, Julia B, Karumanchi, S Ananth, Shapiro, Nathan I, Parikh, Samir M

“…OBJECTIVE:In sepsis, quiescent blood vessels become leaky and inflamed by mechanisms that are incompletely understood. We hypothesized that angiopoietin-2, a…”
Get full text

Gene control of tyrosine kinase TIE2 and vascular manifestations of infections by Ghosh, Chandra C., David, Sascha, Zhang, Ruyang, Berghelli, Anthony, Milam, Katelyn, Higgins, Sarah J., Hunter, Jon, Mukherjee, Aditi, Wei, Yongyue, Tran, Mei, Suber, Freeman, Kobzik, Lester, Kain, Kevin C., Lu, Shulin, Santel, Ansgar, Yano, Kiichiro, Guha, Prajna, Dumont, Daniel J., Christiani, David C., Parikh, Samir M.

“…Ligands of the endothelial-enriched tunica interna endothelial cell kinase 2 (Tie2) are markedly imbalanced in severe infections associated with vascular…”
Get full text

Angiopoietin-1 Requires IQ Domain GTPase-Activating Protein 1 to Activate Rac1 and Promote Endothelial Barrier Defense by David, Sascha, Ghosh, Chandra C, Mukherjee, Aditi, Parikh, Samir M

“…OBJECTIVE—IQ domain GTPase-activating protein 1 (IQGAP1) contributes to cytoskeletal network regulation in epithelial cells by its scaffolding properties and…”
Get full text

What every intensivist should know about Tocilizumab by Hofmaenner, Daniel Andrea, Wendel Garcia , Pedro David, Ganter, Christoph Camille, Brugger, Silvio D, Buehler, Philipp Karl, David, Sascha

“…Given its unknown biological specifics in the critical care context, we have analyzed the longitudinal course of IL-6, together with C-reactive protein (CRP),…”
Get full text