Search Results - "David, M"

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis by Shimada, Kenichi, Crother, Timothy R., Karlin, Justin, Dagvadorj, Jargalsaikhan, Chiba, Norika, Chen, Shuang, Ramanujan, V. Krishnan, Wolf, Andrea J., Vergnes, Laurent, Ojcius, David M., Rentsendorj, Altan, Vargas, Mario, Guerrero, Candace, Wang, Yinsheng, Fitzgerald, Katherine A., Underhill, David M., Town, Terrence, Arditi, Moshe

“…We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling that licensed production of…”
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Hallmarks of neurodegenerative diseases by Wilson, David M., Cookson, Mark R., Van Den Bosch, Ludo, Zetterberg, Henrik, Holtzman, David M., Dewachter, Ilse

“…Decades of research have identified genetic factors and biochemical pathways involved in neurodegenerative diseases (NDDs). We present evidence for the…”
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Twenty-five years of mTOR: Uncovering the link from nutrients to growth by Sabatini, David M.

“…In my PNAS Inaugural Article, I describe the development of the mTOR field, starting with efforts to understand the mechanism of action of the drug rapamycin,…”
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Efficient, uninformative sampling of limb darkening coefficients for two-parameter laws by Kipping, David M.

“…Stellar limb darkening affects a wide range of astronomical measurements and is frequently modelled with a parametric model using polynomials in the cosine of…”
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The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview by Nathan, David M

“…OBJECTIVE The Diabetes Control and Complications Trial (DCCT) was designed to test the glucose hypothesis and determine whether the complications of type 1…”
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OrthoFinder: phylogenetic orthology inference for comparative genomics by Emms, David M, Kelly, Steven

“…Here, we present a major advance of the OrthoFinder method. This extends OrthoFinder's high accuracy orthogroup inference to provide phylogenetic inference of…”
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Realizing the Mass Public Benefit of Evidence-Based Psychological Therapies: The IAPT Program by Clark, David M

“…Empirically supported psychological therapies have been developed for many mental health conditions. However, in most countries only a small proportion of the…”
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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums by Arnold, Steven E., Arvanitakis, Zoe, Macauley-Rambach, Shannon L., Koenig, Aaron M., Wang, Hoau-Yan, Ahima, Rexford S., Craft, Suzanne, Gandy, Sam, Buettner, Christoph, Stoeckel, Luke E., Holtzman, David M., Nathan, David M.

“…Key Points The molecular signalling pathways through which insulin exerts its actions in the body also mediate its roles in synaptic neurotransmission,…”
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Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors by Wang, Chanung, Holtzman, David M

“…As we age, we experience changes in our nighttime sleep and daytime wakefulness. Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems…”
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Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight by Shi, Yang, Holtzman, David M.

“…Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out during the pathogenesis of the disease and in turn modulates disease…”
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DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging by Tiwari, Vinod, Wilson, David M.

“…Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents, such as reactive oxygen species, atmospheric radiation,…”
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OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy by Emms, David M, Kelly, Steven

“…Identifying homology relationships between sequences is fundamental to biological research. Here we provide a novel orthogroup inference algorithm called…”
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Diabetes: Advances in Diagnosis and Treatment by Nathan, David M

“…IMPORTANCE: Chronic diseases have overtaken acute diseases, such as infections, as the major cause of premature mortality worldwide. Diabetes mellitus, a…”
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Phloem Loading and Unloading of Sucrose: What a Long, Strange Trip from Source to Sink by Braun, David M

“…Sucrose is transported from sources (mature leaves) to sinks (importing tissues such as roots, stems, fruits, and seeds) through the phloem tissues in veins…”
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Open science challenges, benefits and tips in early career and beyond by Allen, Christopher, Mehler, David M A

“…The movement towards open science is a consequence of seemingly pervasive failures to replicate previous research. This transition comes with great benefits…”
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An assessment of pre- and within-season remotely sensed variables for forecasting corn and soybean yields in the United States by Johnson, David M.

“…Four timely and broadly available remotely sensed datasets were assessed for inclusion into county-level corn and soybean yield forecasting efforts focused on…”
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Emerging Pandemic Diseases: How We Got to COVID-19 by Morens, David M., Fauci, Anthony S.

“…Infectious diseases prevalent in humans and animals are caused by pathogens that once emerged from other animal hosts. In addition to these established…”
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The neuroscience of prejudice and stereotyping by Amodio, David M.

“…Key Points Prejudice is a fundamental component of human social behaviour that represents the complex interplay between neural processes and situational…”
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Transcription Factors and DNA Play Hide and Seek by Suter, David M.

“…Transcription factors (TFs) bind to specific DNA motifs to regulate the expression of target genes. To reach their binding sites, TFs diffuse in 3D and perform…”
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Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis by Lin, Jeffrey H, Huffman, Austin P, Wattenberg, Max M, Walter, David M, Carpenter, Erica L, Feldser, David M, Beatty, Gregory L, Furth, Emma E, Vonderheide, Robert H

“…Type 1 conventional dendritic cells (cDC1s) are typically thought to be dysregulated secondarily to invasive cancer. Here, we report that cDC1 dysfunction…”
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