Search Results - "David, Larry L."

Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events by Conti, Brian J., Devaraneni, Prasanna K., Yang, Zhongying, David, Larry L., Skach, William R.

“…The ER Sec61 translocon is a large macromolecular machine responsible for partitioning secretory and membrane polypeptides into the lumen, cytosol, and lipid…”
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Characterization of different-sized human αA-crystallin homomers and implications to Asp151 isomerization by Sun, Jiayue, Matsubara, Toshiya, Koide, Tamaki, Lampi, Kirsten J, David, Larry L, Takata, Takumi

“…Site-specific modifications of aspartate residues spontaneously occur in crystallin, the major protein in the lens. One of the primary modification sites is…”
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Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach by Carter-O’Connell, Ian, Jin, Haihong, Morgan, Rory K., Zaja, Roko, David, Larry L., Ahel, Ivan, Cohen, Michael S.

“…ADP-ribosyltransferases (ARTD1–16) have emerged as major downstream effectors of NAD+ signaling in the cell. Most ARTDs (ARTD7 and 8, 10–12, and 14–17)…”
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Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM by Martin, Gregory M, Sung, Min Woo, Yang, Zhongying, Innes, Laura M, Kandasamy, Balamurugan, David, Larry L, Yoshioka, Craig, Shyng, Show-Ling

“…ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1)…”
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The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing by Chen, Yingxiao, Li, Yanping, Dai, Roselyn S, Savage, Jonathan C, Shinde, Ujwal, Klimek, John, David, Larry L, Young, Emma A, Hafner, Markus, Sears, Rosalie C, Sun, Xiao-Xin, Dai, Mu-Shui

“…Abstract The RNA exosome is an essential 3′ to 5′ exoribonuclease complex that mediates degradation, processing and quality control of virtually all eukaryotic…”
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Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs by Smith, Justine R., David, Larry L., Appukuttan, Binoy, Wilmarth, Phillip A.

“…Diseases that involve retinal or choroidal vascular endothelial cells are leading causes of vision loss: age-related macular degeneration, retinal ischemic…”
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Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery by Aryal, Sandeep, Anand, Deepti, Huang, Hongzhan, Reddy, Ashok P., Wilmarth, Phillip A., David, Larry L., Lachke, Salil A.

“…To expedite gene discovery in eye development and its associated defects, we previously developed a bioinformatics resource-tool iSyTE (integrated Systems Tool…”
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Fatiguing exercise reduces cellular passive Young's modulus in human vastus lateralis muscle by Privett, Grace E., Ricci, Austin W., David, Larry L., Wiedenfeld Needham, Karen, Tan, Yong How, Nakayama, Karina H., Callahan, Damien M.

“…Previous studies demonstrated that acute fatiguing exercise transiently reduces whole‐muscle stiffness, which might contribute to increased risk of injury and…”
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Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets by Rodriguez, Kelsie M, Buch-Larsen, Sara C, Kirby, Ilsa T, Siordia, Ivan Rodriguez, Hutin, David, Rasmussen, Marit, Grant, Denis M, David, Larry L, Matthews, Jason, Nielsen, Michael L, Cohen, Michael S

“…Poly(ADP-ribose) polymerase 7 (PARP-7) has emerged as a critically important member of a large enzyme family that catalyzes ADP-ribosylation in mammalian…”
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Insights into the kinetics and dynamics of the furin-cleaved form of PCSK9 by Oleaga, Carlota, Hay, Joshua, Gurcan, Emma, David, Larry L., Mueller, Paul A., Tavori, Hagai, Shapiro, Michael D., Pamir, Nathalie, Fazio, Sergio

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by inducing the degradation of hepatic low density lipoprotein receptors…”
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Proteomics and phosphoproteomics analysis of human lens fiber cell membranes by Wang, Zhen, Han, Jun, David, Larry L, Schey, Kevin L

“…The human lens fiber cell insoluble membrane fraction contains important membrane proteins, cytoskeletal proteins, and cytosolic proteins that are strongly…”
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Role of the retinal vascular endothelial cell in ocular disease by Bharadwaj, Arpita S., Appukuttan, Binoy, Wilmarth, Phillip A., Pan, Yuzhen, Stempel, Andrew J., Chipps, Timothy J., Benedetti, Eric E., Zamora, David O., Choi, Dongseok, David, Larry L., Smith, Justine R.

“…Retinal endothelial cells line the arborizing microvasculature that supplies and drains the neural retina. The anatomical and physiological characteristics of…”
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MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract by Aryal, Sandeep, Anand, Deepti, Hernandez, Francisco G., Weatherbee, Bailey A. T., Huang, Hongzhan, Reddy, Ashok P., Wilmarth, Phillip A., David, Larry L., Lachke, Salil A.

“…While the bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene discovery) effectively identifies human cataract-associated genes, it is…”
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Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway by Rozansky, David J, Cornwall, Tonya, Subramanya, Arohan R, Rogers, Shaunessy, Yang, Yong-Feng, David, Larry L, Zhu, Xiaoman, Yang, Chao-Ling, Ellison, David H

“…Aldosterone regulates volume homeostasis and blood pressure by enhancing sodium reabsorption in the kidney's distal nephron (DN). On the apical surface of…”
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Proteomic profiling of concurrently isolated primary microvascular endothelial cells, pericytes, and vascular smooth muscle cells from adult mouse heart by Cao, Zhiping, Minnier, Jessica, Liu, Lijuan, Scott, Kristin L. Lyon, Reddy, Ashok P., Wilmarth, Phillip A., David, Larry L., Barnes, Anthony P., Grafe, Marjorie R., Kaul, Sanjiv, Alkayed, Nabil J., Davis, Catherine M.

“…The microcirculation serves crucial functions in adult heart, distinct from those carried out by epicardial vessels. Microvessels are governed by unique…”
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Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation by Matsumura, Yoshihiro, David, Larry L, Skach, William R

“…The Hsp/c70 cytosolic chaperone system facilitates competing pathways of protein folding and degradation. Here we use a reconstituted cell-free system to…”
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Metabolic reprogramming during purine stress in the protozoan pathogen Leishmania donovani by Martin, Jessica L, Yates, Phillip A, Soysa, Radika, Alfaro, Joshua F, Yang, Feng, Burnum-Johnson, Kristin E, Petyuk, Vladislav A, Weitz, Karl K, Camp, 2nd, David G, Smith, Richard D, Wilmarth, Phillip A, David, Larry L, Ramasamy, Gowthaman, Myler, Peter J, Carter, Nicola S

“…The ability of Leishmania to survive in their insect or mammalian host is dependent upon an ability to sense and adapt to changes in the microenvironment…”
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p300 and cAMP response element‐binding protein‐binding protein in skeletal muscle homeostasis, contractile function, and survival by Svensson, Kristoffer, LaBarge, Samuel A., Sathe, Abha, Martins, Vitor F., Tahvilian, Shahriar, Cunliffe, Jennifer M., Sasik, Roman, Mahata, Sushil K., Meyer, Gretchen A., Philp, Andrew, David, Larry L., Ward, Samuel R., McCurdy, Carrie E., Aslan, Joseph E., Schenk, Simon

“…Background Reversible ε‐amino acetylation of lysine residues regulates transcription as well as metabolic flux; however, roles for specific lysine…”
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Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity by Yang, Yue, Dai, Min, Wilson, Teresa M, Omelchenko, Irina, Klimek, John E, Wilmarth, Phillip A, David, Larry L, Nuttall, Alfred L, Gillespie, Peter G, Shi, Xiaorui

“…The endothelial-blood/tissue barrier is critical for maintaining tissue homeostasis. The ear harbors a unique endothelial-blood/tissue barrier which we term…”
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The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation by Aslan, Joseph E, Baker, Sandra M, Loren, Cassandra P, Haley, Kristina M, Itakura, Asako, Pang, Jiaqing, Greenberg, Daniel L, David, Larry L, Manser, Ed, Chernoff, Jonathan, McCarty, Owen J T

“…Regulation of the platelet actin cytoskeleton by the Rho family of small GTPases is essential for the proper maintenance of hemostasis. However, little is…”
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