Search Results - "David, J R"

Machine learning with physicochemical relationships: solubility prediction in organic solvents and water by Boobier, Samuel, Hose, David R. J., Blacker, A. John, Nguyen, Bao N.

“…Solubility prediction remains a critical challenge in drug development, synthetic route and chemical process design, extraction and crystallisation. Here we…”
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Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images by Sirinukunwattana, Korsuk, Ahmed Raza, Shan E., Yee-Wah Tsang, Snead, David R. J., Cree, Ian A., Rajpoot, Nasir M.

“…Detection and classification of cell nuclei in histopathology images of cancerous tissue stained with the standard hematoxylin and eosin stain is a challenging…”
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A Stochastic Polygons Model for Glandular Structures in Colon Histology Images by Sirinukunwattana, Korsuk, Snead, David R. J., Rajpoot, Nasir M.

“…In this paper, we present a stochastic model for glandular structures in histology images of tissue slides stained with Hematoxylin and Eosin, choosing colon…”
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Anomalously weak Labrador Sea convection and Atlantic overturning during the past 150 years by Thornalley, David J. R., Oppo, Delia W., Ortega, Pablo, Robson, Jon I., Brierley, Chris M., Davis, Renee, Hall, Ian R., Moffa-Sanchez, Paola, Rose, Neil L., Spooner, Peter T., Yashayaev, Igor, Keigwin, Lloyd D.

“…The Atlantic meridional overturning circulation (AMOC) is a system of ocean currents that has an essential role in Earth’s climate, redistributing heat and…”
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Quenching and ram pressure stripping of simulated Milky Way satellite galaxies by Simpson, Christine M, Grand, Robert J J, Gómez, Facundo A, Marinacci, Federico, Pakmor, Rüdiger, Springel, Volker, Campbell, David J R, Frenk, Carlos S

“…Abstract We present predictions for the quenching of star formation in satellite galaxies of the Local Group from a suite of 30 cosmological zoom simulations…”
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Toward a More Holistic Framework for Solvent Selection by Diorazio, Louis J, Hose, David R. J, Adlington, Neil K

“…An interactive tool has been developed to facilitate solvent selection, allowing consideration of chemical functionality, physical properties, regulatory…”
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Phagocytosis in the Brain: Homeostasis and Disease by Galloway, Dylan A, Phillips, Alexandra E M, Owen, David R J, Moore, Craig S

“…Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during…”
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Holocene oscillations in temperature and salinity of the surface subpolar North Atlantic by Elderfield, Harry, Thornalley, David J. R, McCave, I. Nick

“…The Atlantic meridional overturning circulation (AMOC) transports warm salty surface waters to high latitudes, where they cool, sink and return southwards at…”
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Incidence and Determinants of Mental Health Service Use After Bariatric Surgery by Morgan, David J R, Ho, Kwok M, Platell, Cameron

“…Obesity is associated with an increased prevalence of psychiatric disorders. The association of bariatric surgery with mental health outcomes is poorly…”
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Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts by Sin, Jon, Andres, Allen M., Taylor, David J. R., Weston, Thomas, Hiraumi, Yoshimi, Stotland, Aleksandr, Kim, Brandon J., Huang, Chengqun, Doran, Kelly S., Gottlieb, Roberta A.

“…Myogenesis is a crucial process governing skeletal muscle development and homeostasis. Differentiation of primitive myoblasts into mature myotubes requires a…”
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Regulation of NADPH oxidase 5 by protein kinase C isoforms by Chen, Feng, Yu, Yanfang, Haigh, Steven, Johnson, John, Lucas, Rudolf, Stepp, David W, Fulton, David J R

“…NADPH oxidase5 (Nox5) is a novel Nox isoform which has recently been recognized as having important roles in the pathogenesis of coronary artery disease, acute…”
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Endotoxin Disrupts Circadian Rhythms in Macrophages via Reactive Oxygen Species by Wang, Yusi, Pati, Paramita, Xu, Yiming, Chen, Feng, Stepp, David W, Huo, Yuqing, Rudic, R Daniel, Fulton, David J R

“…The circadian clock is a transcriptional network that functions to regulate the expression of genes important in the anticipation of changes in cellular and…”
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Characterization of an α-Glucosidase Enzyme Conserved in Gardnerella spp. Isolated from the Human Vaginal Microbiome by Bhandari, Pashupati, Tingley, Jeffrey P, Palmer, David R J, Abbott, D Wade, Hill, Janet E

“…spp. in the vaginal microbiome are associated with bacterial vaginosis, in which a lactobacillus-dominated community is replaced with mixed bacteria, including…”
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Substrate Substitution in Kanosamine Biosynthesis Using Phosphonates and Phosphite Rescue by Vetter, Natasha D, Palmer, David R. J

“…Kanosamine is an antibiotic and antifungal compound synthesized from glucose 6-phosphate (G6P) in Bacillus subtilis by the action of three enzymes: NtdC, which…”
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The Deglacial Evolution of North Atlantic Deep Convection by Thornalley, David J. R., Barker, Stephen, Broecker, Wallace S., Elderfield, Henry, McCave, I. Nick

“…Deepwater formation in the North Atlantic by open-ocean convection is an essential component of the overturning circulation of the Atlantic Ocean, which helps…”
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Solar forcing of North Atlantic surface temperature and salinity over the past millennium by Moffa-Sánchez, Paola, Born, Andreas, Hall, Ian R., Thornalley, David J. R., Barker, Stephen

“…Fluctuations in North Atlantic climate and hydrography over the past 1,000 years are seemingly linked to changes in solar irradiance. Reconstructions of marine…”
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YTHDF1 Regulates Pulmonary Hypertension through Translational Control of MAGED1 by Hu, Li, Wang, Jie, Huang, Huijie, Yu, Yanfang, Ding, Jingjing, Yu, Youjia, Li, Kai, Wei, Dong, Ye, Qing, Wang, Fangzhu, Shen, Bin, Chen, Jingyu, Fulton, David J R, Chen, Feng

“…Posttranscriptional modifications are implicated in vascular remodeling of pulmonary hypertension (PH). m A (N -methyladenosine) is an abundant RNA…”
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Validation of digital pathology imaging for primary histopathological diagnosis by Snead, David R J, Tsang, Yee-Wah, Meskiri, Aisha, Kimani, Peter K, Crossman, Richard, Rajpoot, Nasir M, Blessing, Elaine, Chen, Klaus, Gopalakrishnan, Kishore, Matthews, Paul, Momtahan, Navid, Read-Jones, Sarah, Sah, Shatrughan, Simmons, Emma, Sinha, Bidisa, Suortamo, Sari, Yeo, Yen, El Daly, Hesham, Cree, Ian A

“…Aims Digital pathology (DP) offers advantages over glass slide microscopy (GS), but data demonstrating a statistically valid equivalent (i.e. non‐inferior)…”
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A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH by Abuhelwa, Ahmad Y., Foster, David J. R., Upton, Richard N.

“…This study aimed to conduct a quantitative meta-analysis for the values of, and variability in, gastrointestinal (GI) pH in the different GI segments;…”
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Land-sharing versus land-sparing logging: reconciling timber extraction with biodiversity conservation by Edwards, David P., Gilroy, James J., Woodcock, Paul, Edwards, Felicity A., Larsen, Trond H., Andrews, David J. R., Derhé, Mia A., Docherty, Teegan D. S., Hsu, Wayne W., Mitchell, Simon L., Ota, Takahiro, Williams, Leah J., Laurance, William F., Hamer, Keith C., Wilcove, David S.

“…Selective logging is a major driver of rainforest degradation across the tropics. Two competing logging strategies are proposed to meet timber demands with the…”
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