Search Results - "David, Helène"

Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers by Jeltsch-David, Hélène, Muller, Sylviane

“…Key Points Neuropsychiatric symptoms can be an important complication of systemic lupus erythematosus (SLE); among patients with neuropsychiatric SLE (NPSLE),…”
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Targeting Transcription Factors for Cancer Treatment by Lambert, Mélanie, Jambon, Samy, Depauw, Sabine, David-Cordonnier, Marie-Hélène

“…Transcription factors are involved in a large number of human diseases such as cancers for which they account for about 20% of all oncogenes identified so far…”
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Xanthurenic acid: A role in brain intercellular signaling by Maitre, Michel, Taleb, Omar, Jeltsch‐David, Hélène, Klein, Christian, Mensah‐Nyagan, Ayikoe‐Guy

“…Xanthurenic acid (XA) raises a growing multidisciplinary interest based upon its oxidizing properties, its ability to complex certain metal ions, and its…”
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Neuropsychiatric systemic lupus erythematosus and cognitive dysfunction: The MRL- lpr mouse strain as a model by Jeltsch-David, Hélène, Muller, Sylviane

“…Abstract Mouse models of autoimmunity, such as (NZB × NZW)F1, MRL/MpJ-Faslpr (MRL- lpr ) and BXSB mice, spontaneously develop systemic lupus erythematosus…”
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From Systemic Inflammation to Neuroinflammation: The Case of Neurolupus by Bendorius, Mykolas, Po, Chrystelle, Muller, Sylviane, Jeltsch-David, Hélène

“…It took decades to arrive at the general consensus dismissing the notion that the immune system is independent of the central nervous system. In the case of…”
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Restrictive Transfusion Strategy after Cardiac Surgery: Role of Central Venous Oxygen Saturation Trigger: A Randomized Controlled Trial by Zeroual, Norddine, Blin, Cinderella, Saour, Marine, David, Hélène, Aouinti, Safa, Picot, Marie-Christine, Colson, Pascal H., Gaudard, Philippe

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Autoimmunity, neuroinflammation, pathogen load: A decisive crosstalk in neuropsychiatric SLE by Jeltsch-David, Hélène, Muller, Sylviane

“…Abstract Depicting the cellular and molecular bases of the continuous dialogue existing between the peripheral immune and the central nervous systems, as in…”
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Ex vivo and in vivo neuroprotection induced by argon when given after an excitotoxic or ischemic insult by David, Hélène N, Haelewyn, Benoît, Degoulet, Mickael, Colomb, Jr, Denis G, Risso, Jean-Jacques, Abraini, Jacques H

“…In vitro studies have well established the neuroprotective action of the noble gas argon. However, only limited data from in vivo models are available, and…”
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Involvement of Vasopressin in Tissue Hypoperfusion during Cardiogenic Shock Complicating Acute Myocardial Infarction in Rats by Gaudard, Philippe, David, Hélène, Bideaux, Patrice, Sicard, Pierre, Cristol, Jean-Paul, Guillon, Gilles, Richard, Sylvain, Colson, Pascal, Virsolvy, Anne

“…Acute heart failure (AHF) due to acute myocardial infarction (AMI) is likely to involve cardiogenic shock (CS), with neuro-hormonal activation. A relationship…”
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Radiotherapy for geriatric head-and-neck cancer patients: what is the value of standard treatment in the elderly? by Haehl, Erik, Rühle, Alexander, David, Hélène, Kalckreuth, Tobias, Sprave, Tanja, Stoian, Raluca, Becker, Christoph, Knopf, Andreas, Grosu, Anca-Ligia, Nicolay, Nils H

“…Head-and-neck squamous cell carcinoma (HNSCC) is one of the most common malignancies globally, and the number of elderly patients diagnosed with HNSCC is…”
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Acute kidney injury during daptomycin versus vancomycin treatment in cardiovascular critically ill patients: a propensity score matched analysis by Gaudard, Philippe, Saour, Marine, Morquin, David, David, Hélène, Eliet, Jacob, Villiet, Maxime, Daures, Jean-Pierre, Colson, Pascal

“…Gram-positive organisms are a leading cause of infection in cardiovascular surgery. Furthermore, these patients have a high risk of developing postoperative…”
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Growth Outcomes After GH Therapy of Patients Given Long-Term Corticosteroids for Juvenile Idiopathic Arthritis by David, Hélène, Aupiais, Camille, Louveau, Baptiste, Quartier, Pierre, Jacqz-Aigrain, Evelyne, Carel, Jean-Claude, Simon, Dominique

“…Abstract Context Growth hormone (GH) therapy may improve statural growth outcomes in patients with severe juvenile idiopathic arthritis (JIA). Objectives To…”
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Intracellular removal of acetyl, feruloyl and p-coumaroyl decorations on arabinoxylo-oligosaccharides imported from lignocellulosic biomass degradation by Ruminiclostridium cellulolyticum by Liu, Nian, Odinot, Elise, David, Hélène, Vita, Nicolas, Otalvaro, Felipe Mejia, Parsiegla, Goetz, Denis, Yann, Faulds, Craig, Fierobe, Henri-Pierre, Perret, Stéphanie

“…Xylans are polysaccharides that are naturally abundant in agricultural by-products, such as cereal brans and straws. Microbial degradation of arabinoxylan is…”
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Development and validation of a novel prognostic score for elderly head-and-neck cancer patients undergoing radiotherapy or chemoradiation by Rühle, Alexander, Stromberger, Carmen, Haehl, Erik, Senger, Carolin, David, Hélène, Stoian, Raluca, Zamboglou, Constantinos, Knopf, Andreas, Budach, Volker, Grosu, Anca-Ligia, Nicolay, Nils H.

“…•The survival score stratifies elderly HNSCC patients in 3 prognostic groups.•The score is based on performance status, comorbidity burden and baseline CRP…”
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Early temporary mechanical circulatory support for cardiogenic shock: Real-life data from a regional cardiac assistance network by Ughetto, Aurore, Eliet, Jacob, Nagot, Nicolas, David, Hélène, Bazalgette, Florian, Marin, Grégory, Kollen, Sébastien, Mourad, Marc, Zeroual, Norddine, Muller, Laurent, Gaudard, Philippe, Colson, Pascal

“…Temporary mechanical circulatory support as well as multidisciplinary team approach in a regional care organization might improve survival of cardiogenic…”
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Myelin in Alzheimer's disease: culprit or bystander? by Maitre, Michel, Jeltsch-David, Hélène, Okechukwu, Nwife Getrude, Klein, Christian, Patte-Mensah, Christine, Mensah-Nyagan, Ayikoe-Guy

“…Alzheimer's disease (AD) is a neurodegenerative disorder with neuronal and synaptic losses due to the accumulation of toxic amyloid β (Αβ) peptide oligomers,…”
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Neuroprotective effects of xenon: a therapeutic window of opportunity in rats subjected to transient cerebral ischemia by David, Hélène N, Haelewyn, Benoit, Rouillon, Christophe, Lecoq, Myriam, Chazalviel, Laurent, Apiou, Gabriela, Risso, Jean-Jacques, Lemaire, Marc, Abraini, Jacques H

“…Brain insults are a major cause of acute mortality and chronic morbidity. Given the largely ineffective current therapeutic strategies, the development of new…”
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Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Randomized Clinical Trial by Levy, Bruno, Girerd, Nicolas, Amour, Julien, Besnier, Emmanuel, Nesseler, Nicolas, Helms, Julie, Delmas, Clément, Sonneville, Romain, Guidon, Catherine, Rozec, Bertrand, David, Helène, Bougon, David, Chaouch, Oussama, Walid, Oulehri, Hervé, Dupont, Belin, Nicolas, Gaide-Chevronnay, Lucie, Rossignol, Patrick, Kimmoun, Antoine, Duarte, Kevin, Slutsky, Arthur S, Brodie, Daniel, Fellahi, Jean-Luc, Ouattara, Alexandre, Combes, Alain

“…IMPORTANCE: The optimal approach to the use of venoarterial extracorporeal membrane oxygenation (ECMO) during cardiogenic shock is uncertain. OBJECTIVE: To…”
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Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model by Depauw, Sabine, Lambert, Mélanie, Jambon, Samy, Paul, Ananya, Peixoto, Paul, Nhili, Raja, Marongiu, Laura, Figeac, Martin, Dassi, Christelle, Paul-Constant, Charles, Billoré, Benjamin, Kumar, Arvind, Farahat, Abdelbasset A, Ismail, Mohamed A, Mineva, Ekaterina, Sweat, Daniel P, Stephens, Chad E, Boykin, David W, Wilson, W. David, David-Cordonnier, Marie-Hélène

“…Most transcription factors were for a long time considered as undruggable targets because of the absence of binding pockets for direct targeting. HOXA9,…”
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Autophagy in neuroinflammatory diseases by Muller, Sylviane, Brun, Susana, René, Frédérique, de Sèze, Jérôme, Loeffler, Jean-Philippe, Jeltsch-David, Hélène

“…Abstract Autophagy is a metabolically-central process that is crucial in diverse areas of cell physiology. It ensures a fair balance between life and death…”
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