Search Results - "David, Christopher A. W"

Exposure of the Basophilic Cell Line KU812 to Liposomes Reveals Activation Profiles Associated with Potential Anaphylactic Responses Linked to Physico-Chemical Characteristics by Plant-Hately, Alexander J, Eryilmaz, Burcu, David, Christopher A W, Brain, Danielle E, Heaton, Bethany J, Perrie, Yvonne, Liptrott, Neill J

“…Lipidic nanoparticles (LNP), particularly liposomes, have been proven to be a successful and versatile platform for intracellular drug delivery for decades…”
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Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations by Curley, Paul, Hobson, James J, Liptrott, Neill J, Makarov, Edward, Al-Khouja, Amer, Tatham, Lee, David, Christopher A W, Box, Helen, Neary, Megan, Sharp, Joanne, Pertinez, Henry, Meyers, David, Flexner, Charles, Freel Meyers, Caren L, Poluektova, Larisa, Rannard, Steve, Owen, Andrew

“…Long-acting injectable (LAI) formulations promise to deliver patient benefits by overcoming issues associated with non-adherence. A preclinical assessment of…”
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Assessment of changes in autophagic vesicles in human immune cell lines exposed to nano particles by David, Christopher A. W, del Castillo Busto, M. Estela, Cuello-Nuéez, Susana, Goenaga-Infante, Heidi, Barrow, Michael, Fernig, David G, Murray, Patricia, Rosseinsky, Matthew J, Owen, Andrew, Liptrott, Neill J

“…Safe and rational development of nanomaterials for clinical translation requires the assessment of potential biocompatibility. Autophagy, a critical…”
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Nano(bio)Materials Do Not Affect Macrophage Phenotype-A Study Conducted by the REFINE Project by David, Christopher A W, Vermeulen, Jolanda P, Gioria, Sabrina, Vandebriel, Rob J, Liptrott, Neill J

“…Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of…”
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In Vitro Determination of the Immunogenic Impact of Nanomaterials on Primary Peripheral Blood Mononuclear Cells by David, Christopher A W, Barrow, Michael, Murray, Patricia, Rosseinsky, Matthew J, Owen, Andrew, Liptrott, Neill J

“…Investigation of the potential for nanomaterials to generate immunogenic effects is a key aspect of a robust preclinical evaluation. In combination with…”
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Determining the relationship between nanoparticle characteristics and immunotoxicity: key challenges and approaches by David, Christopher AW, Owen, Andrew, Liptrott, Neill J

“…The growing wealth of information regarding the influence that physicochemical characteristics play on nanoparticle biocompatibility and safety is allowing…”
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Age-differential CD13 and interferon expression in airway epithelia affect SARS-CoV-2 infection - Effects of vitamin D by Sposito, Francesca, Pennington, Shaun H, David, Christopher A W, Duggan, Jack, Northey, Sarah, Biagini, Giancarlo A, Liptrott, Neill J, Charras, Amandine, McNamara, Paul S, Hedrich, Christian M

“…Young age and high vitamin D plasma levels have been associated with lower SARS-CoV-2 infection risk and favourable disease outcomes. This study investigated…”
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Umbilical cord mesenchymal stromal cell-derived extracellular vesicles lack the potency to immunomodulate human monocyte-derived macrophages in vitro by da Silva, Tamiris Borges, Rendra, Erika, David, Christopher A.W., Bieback, Karen, Cross, Michael J., Wilm, Bettina, Liptrott, Neill J., Murray, Patricia

“…Mesenchymal stromal cells (MSCs) have been reported to display efficacy in a variety of preclinical models, but without long-term engraftment, suggesting a…”
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Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1 by Heaton, Bethany J., Jensen, Rebecca L., Line, James, David, Christopher A.W., Brain, Danielle E., Chadwick, Amy E., Liptrott, Neill J.

“…SLC2A1 mediates glucose cellular uptake; key to appropriate immune function. Our previous work has shown efavirenz and lopinavir exposure inhibits T cell and…”
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Application of KU812 cells for assessing complement activation related effects by nano(bio)materials by David, Christopher A.W., de la Fonteyne-Blankestijn, Liset J.J., Vermeulen, Jolanda P., Plant-Hately, Alexander J., Vandebriel, Rob J., Liptrott, Neill J.

“…Immunocompatibility issues related to nano(bio)materials, particularly liposomal formulations, involving activation of the complement system have been…”
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An inter-laboratory comparison of an NLRP3 inflammasome activation assay and dendritic cell maturation assay using a nanostructured lipid carrier and a polymeric nanomedicine, as exemplars by Vandebriel, Rob J., David, Christopher A. W., Vermeulen, Jolanda P., Liptrott, Neill J.

“…Nanoparticles including nanomedicines are known to be recognised by and interact with the immune system. As these interactions may result in adverse effects,…”
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NanoMaterials Do Not Affect Macrophage Phenotype—A Study Conducted by the REFINE Project by David, Christopher A. W, Vermeulen, Jolanda P, Gioria, Sabrina, Vandebriel, Rob J, Liptrott, Neill J

“…Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of…”
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Assessing the relationship between nanoparticle physicochemical characteristics and biological interactions: optimisation of in vitro techniques and protocols by David, Christopher A. W

“…The development and implementation of nanomaterials for a variety of clinical applications is increasing as their utility in improving healthcare is…”
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