Search Results - "David, CASTEL"

A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State by Mourikis, Philippos, Sambasivan, Ramkumar, Castel, David, Rocheteau, Pierre, Bizzarro, Valentina, Tajbakhsh, Shahragim

“…Notch signaling plays a key role in virtually all tissues and organs in metazoans; however, limited examples are available for the regulatory role of this…”
Get full text

Notch-Induced miR-708 Antagonizes Satellite Cell Migration and Maintains Quiescence by Baghdadi, Meryem B., Firmino, Joao, Soni, Kartik, Evano, Brendan, Di Girolamo, Daniela, Mourikis, Philippos, Castel, David, Tajbakhsh, Shahragim

“…Critical features of stem cells include anchoring within a niche and activation upon injury. Notch signaling maintains skeletal muscle satellite (stem) cell…”
Get full text

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma by Taylor, Kathryn R, Mackay, Alan, Truffaux, Nathalène, Butterfield, Yaron S, Morozova, Olena, Philippe, Cathy, Castel, David, Grasso, Catherine S, Vinci, Maria, Carvalho, Diana, Carcaboso, Angel M, de Torres, Carmen, Cruz, Ofelia, Mora, Jaume, Entz-Werle, Natacha, Ingram, Wendy J, Monje, Michelle, Hargrave, Darren, Bullock, Alex N, Puget, Stéphanie, Yip, Stephen, Jones, Chris, Grill, Jacques

“…Chris Jones, Jacques Grill and colleagues report the identification of recurrent activating mutations in ACVR1 in diffuse intrinsic pontine gliomas. Diffuse…”
Get full text

Dynamic binding of RBPJ is determined by Notch signaling status by Castel, David, Mourikis, Philippos, Bartels, Stefanie J J, Brinkman, Arie B, Tajbakhsh, Shahragim, Stunnenberg, Hendrik G

“…Notch signaling plays crucial roles in mediating cell fate choices in all metazoans largely by specifying the transcriptional output of one cell in response to…”
Get full text

Intracoronary Injection of In Situ Forming Alginate Hydrogel Reverses Left Ventricular Remodeling After Myocardial Infarction in Swine by Leor, Jonathan, MD, Tuvia, Shmuel, PhD, Guetta, Victor, MD, Manczur, Ferenc, PhD, DVM, Castel, David, DVM, Willenz, Udi, DVM, Petneházy, Örs, DVM, Landa, Natali, PhD, Feinberg, Micha S., MD, Konen, Eli, MD, Goitein, Orly, MD, Tsur-Gang, Orna, PhD, Shaul, Mazal, PhD, Klapper, Lea, PhD, Cohen, Smadar, PhD

“…Objectives This study sought to determine whether alginate biomaterial can be delivered effectively into the infarcted myocardium by intracoronary injection to…”
Get full text

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging by Pagès, Mélanie, Pajtler, Kristian W., Puget, Stéphanie, Castel, David, Boddaert, Nathalie, Tauziède‐Espariat, Arnault, Picot, Stéphanie, Debily, Marie‐Anne, Kool, Marcel, Capper, David, Sainte‐Rose, Christian, Chrétien, Fabrice, Pfister, Stefan M., Pietsch, Torsten, Grill, Jacques, Varlet, Pascale, Andreiuolo, Felipe

“…Ependymoma with RELA fusion has been defined as a novel entity of the revised World Health Organization 2016 classification of tumors of the central nervous…”
Get full text

Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model by Cornet, Sylvie, Carré, Denis, Limana, Lorenzo, Castel, David, Meilin, Sigal, Horne, Ron, Pons, Laurent, Evans, Steven, Lezmi, Stephane, Kalinichev, Mikhail

“…Pain after surgery remains a significant healthcare challenge. Here, abobotulinumtoxinA (aboBoNT-A, DYSPORT) was assessed in a post-surgical pain model in…”
Get full text

Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location by Castel, David, Philippe, Cathy, Kergrohen, Thomas, Sill, Martin, Merlevede, Jane, Barret, Emilie, Puget, Stéphanie, Sainte-Rose, Christian, Kramm, Christof M, Jones, Chris, Varlet, Pascale, Pfister, Stefan M, Grill, Jacques, Jones, David T W, Debily, Marie-Anne

“…Diffuse midline glioma (DMG), H3 K27M-mutant, is a new entity in the updated WHO classification grouping together diffuse intrinsic pontine gliomas and…”
Get full text

New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis by Plessier, Alexandre, Le Dret, Ludivine, Varlet, Pascale, Beccaria, Kévin, Lacombe, Joëlle, Mériaux, Sébastien, Geffroy, Françoise, Fiette, Laurence, Flamant, Patricia, Chrétien, Fabrice, Blauwblomme, Thomas, Puget, Stéphanie, Grill, Jacques, Debily, Marie-Anne, Castel, David

“…Diffuse Instrinsic Pontine Glioma is the most aggressive form of High Grade Gliomas in children. The lack of biological material and the absence of relevant…”
Get full text

Atrx loss as a promising screening tool for the identification of diffuse midline glioma subtype, H3K27/MAPKinase co-altered by Tauziède-Espariat, Arnault, Castel, David, Ajlil, Yassine, Auffret, Lucie, Appay, Romain, Mariet, Cassandra, Hasty, Lauren, Métais, Alice, Chrétien, Fabrice, Grill, Jacques, Varlet, Pascale

Get full text

Small-RNA sequencing identifies dynamic microRNA deregulation during skeletal muscle lineage progression by Castel, David, Baghdadi, Meryem B., Mella, Sébastien, Gayraud-Morel, Barbara, Marty, Virginie, Cavaillé, Jérôme, Antoniewski, Christophe, Tajbakhsh, Shahragim

“…Skeletal muscle satellite cells are quiescent adult resident stem cells that activate, proliferate and differentiate to generate myofibres following injury…”
Get full text

Multimodal Magnetic Resonance Imaging of Treatment Induced Changes to Diffuse Infiltrating Pontine Gliomas in Children and Correlation to Patient Progression Free Survival by Calmon, Raphael, Puget, Stephanie, Varlet, Pascale, Beccaria, Kevin, Blauwblomme, Thomas, Grevent, David, Sainte-Rose, Christian, Castel, David, Dufour, Christelle, Dhermain, Frédéric, Bolle, Stéphanie, Saitovitch, Ana, Zilbovicius, Monica, Brunelle, Francis, Grill, Jacques, Boddaert, Nathalie

“…Abstract Purpose To use multimodal magnetic resonance imaging to quantify treatment induced changes in the whole volume of diffuse infiltrating pontine gliomas…”
Get full text

VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells by Menez, Virginie, Kergrohen, Thomas, Shasha, Tal, Silva-Evangelista, Claudia, Le Dret, Ludivine, Auffret, Lucie, Subecz, Chloé, Lancien, Manon, Ajlil, Yassine, Vilchis, Irma Segoviano, Beccaria, Kévin, Blauwblomme, Thomas, Oberlin, Estelle, Grill, Jacques, Castel, David, Debily, Marie-Anne

“…We previously identified VRK3 as a specific vulnerability in DMG-H3K27M cells in a synthetic lethality screen targeting the whole kinome. The aim of the…”
Get full text

Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysis by Mariet, Cassandra, Castel, David, Grill, Jacques, Saffroy, Raphaël, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Llamas-Guttierrez, Francisco, Chappé, Céline, Puget, Stéphanie, Hasty, Lauren, Chrétien, Fabrice, Métais, Alice, Varlet, Pascale, Tauziède-Espariat, Arnault

“…Posterior fossa group A ependymomas (EPN_PFA) are characterized by a loss of H3 K27 trimethylation due to either EZHIP overexpression or H3 p.K27M mutation,…”
Get full text

Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome by Guerrini-Rousseau, Léa, Tauziède-Espariat, Arnault, Castel, David, Rouleau, Etienne, Sievers, Philipp, Saffroy, Raphaël, Beccaria, Kévin, Blauwblomme, Thomas, Hasty, Lauren, Bourdeaut, Franck, Grill, Jacques, Varlet, Pascale, Debily, Marie-Anne

Get full text

Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations by Yalon, Michal, Tuval-Kochen, Liron, Castel, David, Moshe, Itai, Mazal, Inbal, Cohen, Osher, Avivi, Camila, Rosenblatt, Kineret, Aviel-Ronen, Sarit, Schiby, Ginette, Yahalom, Joachim, Amariglio, Ninette, Pfeffer, Raphael, Lawrence, Yaacov, Toren, Amos, Rechavi, Gideon, Paglin, Shoshana

“…Inhibitors of poly[ADP-ribose] polymerase 1 (PARPis) show promise for treatment of cancers which lack capacity for homologous recombination repair (HRR)…”
Get full text

NF2 and ZFTA evaluation in the diagnostic algorithm of pediatric posterior fossa ependymoma with H3K27ME3 retained expression by Tauziède-Espariat, Arnault, Ajlil, Yassine, Debily, Marie-Anne, Castel, David, Grill, Jacques, Puget, Stéphanie, Hasty, Lauren, Chrétien, Fabrice, Métais, Alice, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Varlet, Pascale

Get full text

Disseminated diffuse midline gliomas, H3K27-altered mimicking diffuse leptomeningeal glioneuronal tumors: a diagnostical challenge by Tauziède-Espariat, Arnault, Siegfried, Aurore, Uro-Coste, Emmanuelle, Nicaise, Yvan, Castel, David, Sevely, Annick, Gambart, Marion, Boetto, Sergio, Hasty, Lauren, Métais, Alice, Chrétien, Fabrice, Benzakoun, Joseph, Puget, Stéphanie, Grill, Jacques, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Ebrahimi, Azadeh, Varlet, Pascale

“…Abstract The outcomes of adolescents/young adults with osteosarcoma have not improved in decades. The chaotic karyotype of this rare tumor has precluded the…”
Get full text

Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification by Andreiuolo, Felipe, Le Teuff, Gwénaël, Bayar, Mohamed Amine, Kilday, John-Paul, Pietsch, Torsten, von Bueren, André O, Witt, Hendrik, Korshunov, Andrey, Modena, Piergiorgio, Pfister, Stefan M, Pagès, Mélanie, Castel, David, Giangaspero, Felice, Chimelli, Leila, Varlet, Pascale, Rutkowski, Stefan, Frappaz, Didier, Massimino, Maura, Grundy, Richard, Grill, Jacques

“…Despite multimodal therapy, prognosis of pediatric intracranial ependymomas remains poor with a 5-year survival rate below 70% and frequent late deaths. This…”
Get full text

The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of "CNS tumors with BCOR internal tandem duplication" by Tauziède-Espariat, Arnault, Pierron, Gaëlle, Siegfried, Aurore, Guillemot, Delphine, Uro-Coste, Emmanuelle, Nicaise, Yvan, Castel, David, Catalaa, Isabelle, Larrieu-Ciron, Delphine, Chaynes, Patrick, de Barros, Amaury, Nicolau, Julien, Gareton, Albane, Lechapt, Emmanuèle, Chrétien, Fabrice, Bourdeaut, Franck, Doz, François, Bouchoucha, Yassine, Grill, Jacques, Beccaria, Kévin, Boddaert, Nathalie, Saffroy, Raphaël, Pagès, Mélanie, Varlet, Pascale

“…Here we report two tumors with a HGNET-BCOR methylation class (MC) but harboring a BCOR fusion with the EP300 gene (encoding the protein p300 which is an…”
Get full text