Search Results - "Davey, Gabriela E."

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J., Davey, Curt A.

“…Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity…”
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Engineering nucleosomes for generating diverse chromatin assemblies by Adhireksan, Zenita, Sharma, Deepti, Lee, Phoi Leng, Bao, Qiuye, Padavattan, Sivaraman, Shum, Wayne K, Davey, Gabriela E, Davey, Curt A

“…Abstract Structural characterization of chromatin is challenging due to conformational and compositional heterogeneity in vivo and dynamic properties that…”
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Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation by Davey, Gabriela E., Adhireksan, Zenita, Ma, Zhujun, Riedel, Tina, Sharma, Deepti, Padavattan, Sivaraman, Rhodes, Daniela, Ludwig, Alexander, Sandin, Sara, Murray, Benjamin S., Dyson, Paul J., Davey, Curt A.

“…The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and…”
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DNA stretching in the nucleosome facilitates alkylation by an intercalating antitumour agent by Davey, Gabriela E, Wu, Bin, Dong, Yuancai, Surana, Uttam, Davey, Curt A

“…DNA stretching in the nucleosome core can cause dramatic structural distortions, which may influence compaction and factor recognition in chromatin. We find…”
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The mechanics behind DNA sequence-dependent properties of the nucleosome by Chua, Eugene Y D, Vasudevan, Dileep, Davey, Gabriela E, Wu, Bin, Davey, Curt A

“…Chromatin organization and composition impart sophisticated regulatory features critical to eukaryotic genomic function. Although DNA sequence-dependent…”
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Chromatin - a New, Old Drug Target by Davey, Gabriela E, Davey, Curt A

“…Chromatin is the therapeutic target for DNA-binding medicinal agents, yet we know substantially more about the interaction of drugs with naked DNA. Current…”
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Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents by Chua, Eugene Y D, Davey, Gabriela E, Chin, Chee Fei, Dröge, Peter, Ang, Wee Han, Davey, Curt A

“…Platinum-based anticancer drugs act therapeutically by forming DNA adducts, but suffer from severe toxicity and resistance problems, which have not been…”
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Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation by Wu, Bin, Davey, Gabriela E., Nazarov, Alexey A., Dyson, Paul J., Davey, Curt A.

“…Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum…”
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Intracellular Ca2+ and Zn2+ Levels Regulate the Alternative Cell Density-dependent Secretion of S100B in Human Glioblastoma Cells by Davey, G E, Murmann, P, Heizmann, C W

“…In recent years, protein translocation has been implicated as the mechanism that controls assembly of signaling complexes and induction of signaling cascades…”
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Correction to article ‘The mechanics behind DNA sequence-dependent properties of the nucleosome’ by Chua, Eugene Y D, Vasudevan, Dileep, Davey, Gabriela E, Wu, Bin, Davey, Curt A

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Human S100A11 Exhibits Differential Steady-State RNA Levels in Various Tissues and a Distinct Subcellular Localization by Inada, Hiroyasu, Naka, Michiko, Tanaka, Toshio, Davey, Gabriela E., Heizmann, Claus W.

“…In order to analyze the steady-state RNA levels of S100A11 in different tissues, a cDNA fragment of human S100A11 was isolated from a cDNA library. The…”
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Targeting epigenetic vulnerabilities of cancer cells by exploiting chromatin structure and chemistry by Adhireksan, Zenita, Davey, Gabriela E., Ma, Zhujun, Palermo, Giulia, Riedel, Tina, Murray, Benjamin S., Nazarov, Alexey A., Hartinger, Christian G., Röthlisberger, Ursula, Dyson, Paul J., Davey, Curt A.

“…Abstract only…”
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Calcium-dependent translocation of S100A11 requires tubulin filaments by Davey, Gabriela E., Murmann, Petra, Hoechli, Mathias, Tanaka, Toshio, Heizmann, Claus W.

“…Protein translocation between different subcellular compartments might play a significant role in various signal transduction pathways. The S100 family is…”
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