Search Results - "Dave Sharp, Zelton"

Acarbose improved survival for Apc+/Min mice by Dodds, Sherry G., Parihar, Manish, Javors, Martin, Nie, Jia, Musi, Nicolas, Dave Sharp, Zelton, Hasty, Paul

“…Acarbose blocks the digestion of complex carbohydrates, and the NIA Intervention Testing Program (ITP) found that it improved survival when fed to mice. Yet,…”
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Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update by Sharp, Zelton Dave, Strong, Randy

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Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction by Miller, Richard A., Harrison, David E., Astle, Clinton M., Fernandez, Elizabeth, Flurkey, Kevin, Han, Melissa, Javors, Martin A., Li, Xinna, Nadon, Nancy L., Nelson, James F., Pletcher, Scott, Salmon, Adam B., Sharp, Zelton Dave, Van Roekel, Sabrina, Winkleman, Lynn, Strong, Randy

“…Summary Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a…”
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice by Nelson, James F, Carter, Christy S, Pahor, Marco, Frenkel, Krystyna, Miller, Richard A, Nadon, Nancy L, Wilkinson, J. Erby, Fernandez, Elizabeth, Javors, Martin A, Flurkey, Kevin, Astle, Clinton M, Sharp, Zelton Dave, Harrison, David E, Strong, Randy

“…Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and…”
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Activation of estrogen receptor-alpha by E2 or EGF induces temporally distinct patterns of large-scale chromatin modification and mRNA transcription by Berno, Valeria, Amazit, Larbi, Hinojos, Cruz, Zhong, Jeannie, Mancini, Maureen G, Sharp, Zelton Dave, Mancini, Michael A

“…Estrogen receptor-alpha (ER) transcription function is regulated in a ligand-dependent (e.g., estradiol, E2) or ligand-independent (e.g., growth factors)…”
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eRapa Restores a Normal Life Span in a FAP Mouse Model by HASTY, Paul, LIVI, Carolina B, LISHI SUN, HUREZ, Vincent, CURIEL, Tyler J, ZELTON DAVE SHARP, DODDS, Sherry G, JONES, Diane, STRONG, Randy, JAVORS, Martin, FISCHER, Kathleen E, SLOANE, Lauren, MURTHY, Kruthi, HUBBARD, Gene

“…Mutation of a single copy of the adenomatous polyposis coli (APC) gene results in familial adenomatous polyposis (FAP), which confers an extremely high risk…”
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Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice by Sharp, Zelton Dave, Bartke, Andrzej

“…How growth hormone (GH) stimulates protein synthesis is unknown. Phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways…”
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mTOR inhibitors for treatment of low-risk prostate cancer by Liss, Michael A., Rickborn, Lanette, DiGiovanni, John, Bacich, Dean, DeGraffenried, Linda A., Parihar, Manish, Thompson, Ian M., Sharp, Zelton Dave

“…Prostate cancer incidence increases with age; along with many other cancers, it could be considered a disease of aging. Prostate cancer screening has led to a…”
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Aging and cancer: can mTOR inhibitors kill two birds with one drug? by Sharp, Zelton Dave, Richardson, Arlan

“…The main risk factor for a number of diseases, including cancer, is aging. By delaying the effects of aging, many years of research indicate that diseases…”
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Adaptations to chronic rapamycin in mice by Dodds, Sherry G., Livi, Carolina B., Parihar, Manish, Hsu, Hang-Kai, Benavides, Adriana D., Morris, Jay, Javors, Martin, Strong, Randy, Christy, Barbara, Hasty, Paul, Sharp, Zelton Dave

“…Rapamycin inhibits mechanistic (or mammalian) target of rapamycin (mTOR) that promotes protein production in cells by facilitating ribosome biogenesis (RiBi)…”
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Rapamycin, the only drug that consistently demonstrated to increase mammalian longevity. An update by Sharp, Zelton Dave, Strong, Randy

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Abstract 671: mTORC1 suppression in Paneth cells prevents tumors in a mouse model of intestinal cancer by Parihar, Manish, Dodds, Sherry G., Hasty, Paul, Sharp, Zelton Dave

“…Abstract The mechanistic (or mammalian) target of rapamycin, mTOR, is a highly conserved PI3K-related kinase that regulates cell growth, proliferation,…”
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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice by Miller, Richard A, Harrison, David E, Astle, C M, Baur, Joseph A, Boyd, Angela Rodriguez, de Cabo, Rafael, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin A, Nelson, James F, Orihuela, Carlos J, Pletcher, Scott, Sharp, Zelton Dave, Sinclair, David, Starnes, Joseph W, Wilkinson, J Erby, Nadon, Nancy L, Strong, Randy

“…Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including…”
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mTORC1 and p53: Clash of the gods? by Hasty, Paul, Sharp, Zelton Dave, Curiel, Tyler J., Campisi, Judith

“…A balance must be struck between cell growth and stress responses to ensure that cells proliferate without accumulating damaged DNA. This balance means that…”
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Rapamycin Extends Life Span in Apc Colon Cancer FAP Model by Parihar, Manish, Dodds, Sherry G., Hubbard, Gene, Javors, Martin A., Strong, Randy, Hasty, Paul, Sharp, Zelton Dave

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Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice by Hurez, Vincent, Dao, Vinh, Liu, Aijie, Pandeswara, Srilakshmi, Gelfond, Jonathan, Sun, Lishi, Bergman, Molly, Orihuela, Carlos J., Galvan, Veronica, Padrón, Álvaro, Drerup, Justin, Liu, Yang, Hasty, Paul, Sharp, Zelton Dave, Curiel, Tyler J.

“…Summary The mammalian (mechanistic) target of rapamycin (mTOR) regulates critical immune processes that remain incompletely defined. Interest in mTOR inhibitor…”
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The Role of mTOR Signaling in Controlling Mammalian Life Span: What a Fungicide Teaches Us About Longevity by Sharp, Zelton Dave, Strong, Randy

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Aging and TOR: interwoven in the fabric of life by Sharp, Zelton Dave

“…Longstanding results with calorie and growth factor restriction plus recent results with the first interventional drug suggest that retarding the pace of aging…”
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Rapamycin Extends Life Span in ApcMin/+ Colon Cancer FAP Model by Parihar, Manish, Dodds, Sherry G., Hubbard, Gene, Javors, Martin A., Strong, Randy, Hasty, Paul, Sharp, Zelton Dave

“…We previously showed that lifelong rapamycin treatment of short-lived ApcMin/+ mice, a model for familial adenomatous polyposis, resulted in a normal lifespan…”
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Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors by Livi, Carolina B, Hardman, Rulon L, Christy, Barbara A, Dodds, Sherry G, Jones, Diane, Williams, Charnae, Strong, Randy, Bokov, Alex, Javors, Martin A, Ikeno, Yuji, Hubbard, Gene, Hasty, Paul, Sharp, Zelton Dave

“…Chronic treatment of mice with an enterically released formulation of rapamycin (eRapa) extends median and maximum life span, partly by attenuating cancer. The…”
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