Search Results - "Dave, Vrushank"

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases by Uversky, Vladimir N, Davé, Vrushank, Iakoucheva, Lilia M, Malaney, Prerna, Metallo, Steven J, Pathak, Ravi Ramesh, Joerger, Andreas C

“…Uversky et al examine pathological unfoldomics of uncontrolled chaos with regard to intrinsically disordered proteins and human diseases…”
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One mouse, one patient paradigm: New avatars of personalized cancer therapy by Malaney, Prerna, Nicosia, Santo V, Davé, Vrushank

“…Highlights • Current status, challenges and future use of Avatar Mice and Co-clinical models. • Avatar Mice and Co-clinical models of myriad cancers to assess…”
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Microproteins transitioning into a new Phase: Defining the undefined by Sahgal, Aayushi, Uversky, Vladimir, Davé, Vrushank

“…Recent advancements in omics technologies have unveiled a hitherto unknown group of short polypeptides called microproteins (miPs). Despite their size,…”
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PTEN proteoforms in biology and disease by Malaney, Prerna, Uversky, Vladimir N., Davé, Vrushank

“…Proteoforms are specific molecular forms of protein products arising from a single gene that possess different structures and different functions. Therefore, a…”
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Transcriptional Control of Lung Morphogenesis by Maeda, Yutaka, Dave, Vrushank, Whitsett, Jeffrey A

“…Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and The University of Cincinnati College of Medicine,…”
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PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer by Malaney, Prerna, Palumbo, Emily, Semidey-Hurtado, Jonathan, Hardee, Jamaal, Stanford, Katherine, Kathiriya, Jaymin J, Patel, Deepal, Tian, Zhi, Allen-Gipson, Diane, Davé, Vrushank

“…PTEN phosphorylation at its C-terminal (C-tail) serine/threonine cluster negatively regulates its tumor suppressor function. However, the consequence of such…”
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Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility by Malaney, Prerna, Pathak, Ravi Ramesh, Xue, Bin, Uversky, Vladimir N., Davé, Vrushank

“…IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain…”
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The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy by Malaney, Prerna, Uversky, Vladimir N, Davé, Vrushank

“…Aberrant activation of the PI3K/Akt/mTOR pathway is observed in several cancers and hyper proliferative disorders. PTEN, a tumor suppressor gene, negatively…”
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Analyzing aggregation propensities of clinically relevant PTEN mutants: a new culprit in pathogenesis of cancer and other PTENopathies by Palumbo, Emily, Zhao, Bi, Xue, Bin, Uversky, Vladimir N., Davé, Vrushank

“…While studies on pathological protein aggregation are largely limited to neurodegenerative disease, emerging evidence suggests that other diseases are also…”
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Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach by Malaney, Prerna, Uversky, Vladimir N., Davé, Vrushank

“…Intrinsically disordered proteins (IDPs) are proteins that lack stable higher order structures for the entire protein molecule or a significant portion of it…”
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Integrating Omics Technologies to Study Pulmonary Physiology and Pathology at the Systems Level by Pathak, Ravi Ramesh, Davé, Vrushank

“…Assimilation and integration of “omics” technologies, including genomics, epigenomics, proteomics, and metabolomics has readily altered the landscape of…”
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Loss of phosphatase and tensin homolog (PTEN) induces leptin-mediated leptin gene expression: feed-forward loop operating in the lung by Pathak, Ravi Ramesh, Grover, Aditya, Malaney, Prerna, Quarni, Waise, Pandit, Ashish, Allen-Gipson, Diane, Davé, Vrushank

“…Elevated levels of systemic and pulmonary leptin are associated with diseases related to lung injury and lung cancer. However, the role of leptin in lung…”
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Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis by Kathiriya, Jaymin J, Nakra, Niyati, Nixon, Jenna, Patel, Puja S, Vaghasiya, Vijay, Alhassani, Ahmed, Tian, Zhi, Allen-Gipson, Diane, Davé, Vrushank

“…Idiopathic pulmonary fibrosis (IPF) is characterized by lung remodeling arising from epithelial injury, aberrant fibroblast growth, and excessive deposition of…”
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Presence and utility of intrinsically disordered regions in kinases by Kathiriya, Jaymin J, Pathak, Ravi Ramesh, Clayman, Eric, Xue, Bin, Uversky, Vladimir N, Davé, Vrushank

“…Since aberrant cell signaling pathways underlie majority of pathophysiological morbidities, kinase inhibitors are routinely used for pharmacotherapy. However,…”
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Structural pliability adjacent to the kinase domain highlights contribution of FAK1 IDRs to cytoskeletal remodeling by Kathiriya, Jaymin J., Pathak, Ravi Ramesh, Bezginov, Alexandr, Xue, Bin, Uversky, Vladimir N., Tillier, Elisabeth R.M., Davé, Vrushank

“…Therapeutic protein kinase inhibitors are designed on the basis of kinase structures. Here, we define intrinsically disordered regions (IDRs) in structurally…”
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Signaling pathways in the epithelial origins of pulmonary fibrosis by Hardie, William D., Hagood, James S., Dave, Vrushank, Perl, Anne-Karina T., Whitsett, Jeffrey A., Korfhagen, Thomas R., Glasser, Stephan

“…Pulmonary fibrosis complicates a number of disease processes and leads to substantial morbidity and mortality. Idiopathic pulmonary fibrosis (IPF) is perhaps…”
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PARP-2 Interacts with TTF-1 and Regulates Expression of Surfactant Protein-B by Maeda, Yutaka, Hunter, Thomas C., Loudy, David E., Davé, Vrushank, Schreiber, Valérie, Whitsett, Jeffrey A.

“…Thyroid transcription factor 1 (TTF-1/Nkx-2.1) plays a critical role in lung morphogenesis and regulates the expression of lung-specific genes, including the…”
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A systems approach to mapping transcriptional networks controlling surfactant homeostasis by Xu, Yan, Zhang, Minlu, Wang, Yanhua, Kadambi, Pooja, Dave, Vrushank, Lu, Long J, Whitsett, Jeffrey A

“…Pulmonary surfactant is required for lung function at birth and throughout life. Lung lipid and surfactant homeostasis requires regulation among multi-tiered…”
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Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling by Kathiriya, Jaymin J., Pathak, Ravi Ramesh, Bezginov, Alexandr, Xue, Bin, Uversky, Vladimir N., Tillier, Elisabeth R.M., Davé, Vrushank

“…We present data on the evolution of intrinsically disordered regions (IDRs) taking into account the entire human protein kinome. The evolutionary data of the…”
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Nuclear Factor of Activated T Cells Regulates Transcription of the Surfactant Protein D Gene (Sftpd) via Direct Interaction with Thyroid Transcription Factor-1 in Lung Epithelial Cells by Davé, Vrushank, Childs, Tawanna, Whitsett, Jeffrey A

“…Surfactant protein D (SP-D) plays critical roles in host defense, surfactant homeostasis, and pulmonary immunomodulation. Here, we identify a role of nuclear…”
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