Search Results - "Dave, Apeksha"

In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease by Bose, Sourav K., White, Brandon M., Kashyap, Meghana V., Dave, Apeksha, De Bie, Felix R., Li, Haiying, Singh, Kshitiz, Menon, Pallavi, Wang, Tiankun, Teerdhala, Shiva, Swaminathan, Vishal, Hartman, Heather A., Jayachandran, Sowmya, Chandrasekaran, Prashant, Musunuru, Kiran, Jain, Rajan, Frank, David B., Zoltick, Philip, Peranteau, William H.

“…In utero base editing has the potential to correct disease-causing mutations before the onset of pathology. Mucopolysaccharidosis type I (MPS-IH, Hurler…”
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Small RNA combination therapy for lung cancer by Xue, Wen, Dahlman, James E., Tammela, Tuomas, Khan, Omar F., Sood, Sabina, Dave, Apeksha, Cai, Wenxin, Chirino, Leilani M., Yang, Gillian R., Bronson, Roderick, Crowley, Denise G., Sahay, Gaurav, Schroeder, Avi, Langer, Robert, Anderson, Daniel G., Jacks, Tyler

“…MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we…”
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Disparities in Stage-Specific Guideline-Concordant Cancer-Directed Treatment for Patients with Pancreatic Adenocarcinoma by Hamad, Ahmad, DePuccio, Matthew, Reames, Bradley N., Dave, Apeksha, Kurien, Natasha, Cloyd, Jordan M, Shen, Chengli, Pawlik, Timothy M., Tsung, Allan, McAlearney, Ann Scheck, Ejaz, Aslam

“…Background The utilization of cancer-directed treatment for patients with all stages of pancreatic cancer in the USA is unknown. This study sought to examine…”
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Evaluating the ACS NSQIP Risk Calculator in Primary Pancreatic Neuroendocrine Tumor: Results from the US Neuroendocrine Tumor Study Group by Dave, Apeksha, Beal, Eliza W., Lopez-Aguiar, Alexandra G., Poultsides, George, Makris, Eleftherios, Rocha, Flavio G., Kanji, Zaheer, Ronnekleiv-Kelly, Sean, Rendell, Victoria R., Fields, Ryan C., Krasnick, Bradley A., Idrees, Kamran, Smith, Paula Marincola, Nathan, Hari, Beems, Megan, Maithel, Shishir K., Pawlik, Timothy M., Schmidt, Carl R., Dillhoff, Mary E.

“…Background In a changing health care environment where patient outcomes will be more closely scrutinized, the ability to predict surgical complications is…”
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Late-Gestation Hematopoietic Cell Transplantation with Transient T Cell Depletion Significantly Improves Disease Phenotype in the Townes Mouse Model of Sickle Cell Disease by Riley, John S, Dave, Apeksha, Abdulmalik, Osheiza Y., Peranteau, William H

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Sustained Engraftment in Fanconi Anemia (FA) Mice Using in Utero Hematopoietic Cell Transplantation (IUHCT) by Dave, Apeksha, Liu, Suying, Riley, John S, Bose, Sourav, Menon, Pallavi, Kurre, Peter, Peranteau, William H

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Maternal Cas9 Antibodies Do Not Prevent Fetal Gene Editing by Riley, John, Dave, Apeksha, Luks, Valerie, Berkowitz, Cara L, Zoltick, Philip W, Peranteau, William Hughes

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Targeting of Fetal and Neonatal Pulmonary Epithelial Cells for Therapeutic Applications by Dave, Apeksha, Berkowitz, Cara, Luks, Valerie, Puc, Marcelina, Riley, John, Carpenter, Marco D, Alameh, Mohamad-Gabriel, Peranteau, William

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Fetal Pulmonary Genome Modification via Direct Intratracheal Injection in the Mouse by White, Brandon M., Bose, Sourav K., Palanki, Rohan, Dave, Apeksha, Mitchell, Michael J., Peranteau, William H.

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Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery by Swingle, Kelsey L., Billingsley, Margaret M., Bose, Sourav K., White, Brandon, Palanki, Rohan, Dave, Apeksha, Patel, Savan K., Gong, Ningqiang, Hamilton, Alex G., Alameh, Mohamad-Gabriel, Weissman, Drew, Peranteau, William H., Mitchell, Michael J.

“…Congenital disorders resulting in pathological protein deficiencies are most often treated postnatally with protein or enzyme replacement therapies. However,…”
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In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight by Dahlman, James E., Barnes, Carmen, Khan, Omar F., Thiriot, Aude, Jhunjunwala, Siddharth, Shaw, Taylor E., Xing, Yiping, Sager, Hendrik B., Sahay, Gaurav, Speciner, Lauren, Bader, Andrew, Bogorad, Roman L., Yin, Hao, Racie, Tim, Dong, Yizhou, Jiang, Shan, Seedorf, Danielle, Dave, Apeksha, Singh Sandhu, Kamaljeet, Webber, Matthew J., Novobrantseva, Tatiana, Ruda, Vera M., Lytton-Jean, Abigail K. R., Levins, Christopher G., Kalish, Brian, Mudge, Dayna K., Perez, Mario, Abezgauz, Ludmila, Dutta, Partha, Smith, Lynelle, Charisse, Klaus, Kieran, Mark W., Fitzgerald, Kevin, Nahrendorf, Matthias, Danino, Dganit, Tuder, Rubin M., von Andrian, Ulrich H., Akinc, Akin, Panigrahy, Dipak, Schroeder, Avi, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G.

“…Dysfunctional endothelium contributes to more diseases than any other tissue in the body. Small interfering RNAs (siRNAs) can help in the study and treatment…”
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Intracranial Delivery of Lipid Nanoparticles in the Murine Model by Berkowitz, Cara L, Luks, Valerie L, Dave, Apeksha, Menon, Pallavi V, Carpenter, Marco D, Riley, John S, Alameh, Mohamad-Gabriel, Peranteau, William H

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The Extrauterine Environment for Neonatal Development Supports Mid-Gestation Fetal Lambs by Dave, Apeksha, Nieuwburgh, Maureen Peers de, Hayes, Kevin B, Ngo, Michelle, Ebrahimi, Mina, Slipenchuk, Matthew, Khan, Sameer A, Choudhry, Alia M, Davey, Marcus G, Flake, Alan W

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Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease by Palanki, Rohan, Bose, Sourav K., Dave, Apeksha, White, Brandon M., Berkowitz, Cara, Luks, Valerie, Yaqoob, Fazeela, Han, Emily, Swingle, Kelsey L., Menon, Pallavi, Hodgson, Emily, Biswas, Arijit, Billingsley, Margaret M., Li, Li, Yiping, Fan, Carpenter, Marco, Trokhan, Alexandra, Yeo, Julie, Johana, Nuryanti, Wan, Tan Yi, Alameh, Mohamad-Gabriel, Bennett, Frederick Chris, Storm, Phillip B., Jain, Rajan, Chan, Jerry, Weissman, Drew, Mitchell, Michael J., Peranteau, William H.

“…Delivery of mRNA-based therapeutics to the perinatal brain holds great potential in treating congenital brain diseases. However, nonviral delivery platforms…”
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Biomimetic and synthetic esophageal tissue engineering by Jensen, Todd, Blanchette, Alex, Vadasz, Stephanie, Dave, Apeksha, Canfarotta, Michael, Sayej, Wael N, Finck, Christine

“…Abstract Background/Purpose A tissue-engineered esophagus offers an alternative for the treatment of pediatric patients suffering from severe esophageal…”
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National Congenital Diaphragmatic Hernia Outcomes: Assessing Volume-Outcomes Relationships Using the 2016 KID Database by Bose, Sourav, Dave, Apeksha, White, Brandon, Dasani, Serena, Palanki, Rohan, Teerdhala, Shiva S., Rintoul, Natalie, Laje, Pablo, Hedrick, Holly L., Peranteau, William H.

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Preexisting maternal immunity to AAV but not Cas9 impairs in utero gene editing in mice by Riley, John S, Luks, Valerie L, Berkowitz, Cara L, Dumitru, Ana Maria, Kus, Nicole J, Dave, Apeksha, Menon, Pallavi, De Paepe, Monique E, Jain, Rajan, Li, Li, Dugoff, Lorraine, Teefey, Christina Paidas, Alameh, Mohamad-Gabriel, Zoltick, Philip W, Peranteau, William H

“…In utero gene editing (IUGE) is a potential treatment for inherited diseases that cause pathology before or soon after birth. Preexisting immunity to…”
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Assessment of extremely premature lambs supported by the Extrauterine Environment for Neonatal Development (EXTEND) by Peers de Nieuwburgh, Maureen, Dave, Apeksha, Khan, Sameer A, Ngo, Michelle, Hayes, Kevin B, Slipenchuk, Matthew, Lieberman, Evan, Youssef, Mohanad R, Crompton, Dan, Choudhry, Alia Mohsin, Guo, Nan, Tian, Zhiyun, Rychik, Jack, Davey, Marcus G, Flake, Alan W

“…Our team has previously reported physiologic support by the EXTra-uterine Environment for Neonatal Development (EXTEND) of 105 to 117 days gestational age (GA)…”
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Comment on: Premature delivery in the domestic sow in response to in utero delivery of AAV9 to fetal piglets by Dave, Apeksha, Berkowitz, Cara L., Luks, Valerie L., White, Brandon M., Palanki, Rohan, Carpenter, Marco D., Riley, John S., Bose, Sourav K., Li, Haiying, Li, Li, Menon, Pallavi V., Teerdhala, Shiva, Ebrahimi, Mina, Zoltick, Philip W., Peranteau, William H.

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In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells by Palanki, Rohan, Riley, John S, Bose, Sourav K, Luks, Valerie, Dave, Apeksha, Kus, Nicole, White, Brandon M, Ricciardi, Adele S, Swingle, Kelsey L, Xue, Lulu, Sung, Derek, Thatte, Ajay S, Safford, Hannah C, Chaluvadi, Venkata S, Carpenter, Marco, Han, Emily L, Maganti, Rohin, Hamilton, Alex G, Mrksich, Kaitlin, Billingsley, Margaret B, Zoltick, Philip W, Alameh, Mohamad-Gabriel, Weissman, Drew, Mitchell, Michael J, Peranteau, William H

“…Monogenic blood diseases are among the most common genetic disorders worldwide. These diseases result in significant pediatric and adult morbidity, and some…”
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