Search Results - "Davalli, P."
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Genetic inactivation of ApoJ clusterin: effects on prostate tumourigenesis and metastatic spread
Published in Oncogene (10-12-2009)“…ApoJ/Clusterin (CLU) is a heterodimeric protein localized in the nucleus, cytoplasm or secretory organelles and involved in cell survival and neoplastic…”
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Manipulation of the expression of regulatory genes of polyamine metabolism results in specific alterations of the cell-cycle progression
Published in Biochemical journal (15-02-2001)“…We have previously reported that cyclical phases of accumulation and depletion of polyamines occur during cell-cycle progression. Regulatory ornithine…”
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Coordinate changes of polyamine metabolism regulatory proteins during the cell cycle of normal human dermal fibroblasts
Published in FEBS letters (05-03-1999)“…In human dermal fibroblasts, brought to quiescence (G 0) by serum starvation, the S phase peaked 24 h and G 2/M phases 36 h after serum re-addition. Under the…”
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Different localization of spermidine/spermine N 1 -acetyltransferase and ornithine decarboxylase transcripts in the rat kidney
Published in FEBS letters (27-12-1995)“…In situ hybridization histochemistry of transverse sections from male rat kidney showed that the mRNA of the regulatory enzyme of polyamine degradation,…”
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Androgen responsiveness and intrarenal localization of transcripts coding for the enzymes of polyamine metabolism in the mouse
Published in Biochemistry and cell biology (2001)“…Polyamines, spermidine (SPD), and spermine (SPM) are intracellular polycations required for cell growth and differentiation. Their biosynthetic precursor, the…”
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In vivo accumulation of sulfated glycoprotein 2 mRNA in rat thymocytes upon dexamethasone-induced cell death
Published in Biochemical and biophysical research communications (29-03-1991)“…Two hours after a single intraperitoneal injection of dexamethasone (20 micrograms/Kg b.w.) into adult male rats, a typical ladder of DNA fragments was…”
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Gene relaxation and aging: Changes in the abundance of rat ventral prostate SGP-2 (clusterin) and ornithine decarboxylase mRNAs
Published in FEBS letters (18-07-1994)“…Sulfated glycoprotein 2 (SGP-2) mRNA progressively increased in the ventral prostate of the aging rat, reaching, at 24 months, 4-fold higher than at 3 months…”
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The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression
Published in Carcinogenesis (New York) (01-11-2004)“…Clusterin (CLU) protein is widely distributed in animal tissues and is involved in many different processes, including apoptosis and neoplastic transformation…”
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Increased levels of clusterin mRNA in the ventral prostate of the aging rat are associated to increases in cuboidal (atrophic) cell population and not to changes in apoptotic activity
Published in Biochemistry and cell biology (01-11-1994)“…In the ventral prostate of the intact rat, clusterin mRNA is expressed in a small population of cuboidal epithelial cells undergoing apoptosis, but not in the…”
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Increased brain concentrations of polyamines in rats with encephalopathy due to a galactosamine-induced fulminant hepatic failure
Published in Pharmacological research (01-07-1995)“…Polyamine concentrations including putrescine, spermidine and spermine were documented in two brain areas of rats with mild and severe stages of hepatic…”
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Cadmium induction of renal and hepatic ornithine decarboxylase activity in the rat. Effects of sex hormones and involvement of the renin-angiotensin system
Published in Biochemical pharmacology (18-08-1992)“…We investigated the effect of sex hormones on the sex-dependent response of rat kidney ornithine decarboxylase (ODC) activity to cadmium (Cd) administration…”
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Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression
Published in Oncogene (20-06-2002)“…Clusterin is a highly conserved, widely distributed glycoprotein whose biological significance is still debated. Involved in many biological processes and…”
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Molecular classification of green tea catechin-sensitive and green tea catechin-resistant prostate cancer in the TRAMP mice model by quantitative real-time PCR gene profiling
Published in Carcinogenesis (New York) (01-05-2006)“…We previously found that human prostate cancer (CaP) progression is accompanied by differential expression of a panel of 8 informative genes, some of which are…”
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Determination of the polyamine content of rat heart mitochondria by the use of heparin-Sepharose
Published in Applied biochemistry and biotechnology (01-06-1985)“…Heparin-sepharose has been utilized to remove polyamines adsorbed to the cytoplasmic surface of rat heart mitochondria. The results obtained can be summarized…”
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Polyamine distribution and activity of their biosynthetic enzymes in the European sea bass (Dicentrarchus labrax L.) compared to the rat
Published in Comparative biochemistry and physiology. B, Comparative biochemistry (1987)“…1. In the liver, heart and brain of the European sea bass, putrescine concentrations are much higher than in the equivalent rat tissues; spermidine and…”
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Tumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin (sulfated glycoprotein 2) in human prostate cancer specimens
Published in Cancer research (Chicago, Ill.) (2000)“…Using Northern blotting, the expression levels of the genes for polyamine metabolism regulatory proteins and clusterin have been measured in a series of 23…”
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Effects of neurotoxic and mechanical lesions of the mesostriatal dopamine pathway on striatal polyamine levels in the rat: modulation by chronic ganglioside GM1 treatment
Published in Neuroscience letters (11-11-1985)“…In male rats, partial hemitransections but not 6-hydroxydopamine (6-OHDA)-induced lesions of the mesostriatal dopamine (DA) pathway produce after 7 days a…”
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Successful prediction of prostate cancer recurrence by gene profiling in combination with clinical data: A 5-year follow-up study
Published in Cancer research (Chicago, Ill.) (01-07-2003)“…We show here that gene expression profiling, performed with conventional techniques and focused on a selected group of genes, when used in combination with…”
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