Search Results - "Daval, Jean‐Luc"

Folate and fetal programming: a play in epigenomics? by Guéant, Jean-Louis, Namour, Fares, Guéant-Rodriguez, Rosa-Maria, Daval, Jean-Luc

“…Folate plays a key role in the interactions between nutrition, fetal programming, and epigenomics. Maternal folate status influences DNA methylation,…”
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N‐homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia by Bossenmeyer‐Pourié, Carine, Smith, A David, Lehmann, Sylvain, Deramecourt, Vincent, Sablonnière, Bernard, Camadro, Jean‐Michel, Pourié, Grégory, Kerek, Racha, Helle, Deborah, Umoret, Remy, Guéant‐Rodriguez, Rosa‐Maria, Rigau, Valérie, Gabelle, Audrey, Sequeira, Jeffrey M, Quadros, Edward V, Daval, Jean‐Luc, Guéant, Jean‐Louis

“…The pathomechanisms that associate a deficit in folate and/or vitamin B12 and the subsequent hyperhomocysteinemia with pathological brain ageing are unclear…”
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The Fate of Transplanted Olfactory Progenitors Is Conditioned by the Cell Phenotypes of the Receiver Brain Tissue in Cocultures by Pourié, Grégory, Akchiche, Nassila, Millot, Jean-Louis, Guéant, Jean-Louis, Daval, Jean-Luc, Bossenmeyer-Pourié, Carine

“…Among the numerous candidates for cell therapy of the central nervous system (CNS), olfactory progenitors (OPs) represent an interesting alternative because…”
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Homocysteinylation of neuronal proteins contributes to folate deficiency‐associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells by Akchiche, Nassila, Bossenmeyer‐Pourié, Carine, Kerek, Racha, Martin, Nicolas, Pourié, Grégory, Koziel, Violette, Helle, Déborah, Alberto, Jean‐Marc, Ortiou, Sandrine, Camadro, Jean‐Michel, Léger, Thibaut, Guéant, Jean‐Louis, Daval, Jean‐Luc

“…Despite the key role in neuronal development of a deficit in the methyl donor folate, little is known on the underlying mechanisms. We therefore studied the…”
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Folate and Cobalamin Deficiencies during Pregnancy Disrupt the Glucocorticoid Response in Hypothalamus through N -Homocysteinilation of the Glucocorticoid Receptor by Michel, Arnaud, Kokten, Tunay, Saber-Cherif, Lynda, Umoret, Rémy, Alberto, Jean-Marc, Helle, Déborah, Julien, Amélia, Daval, Jean-Luc, Guéant, Jean-Louis, Bossenmeyer-Pourié, Carine, Pourié, Grégory

“…Vitamin B9 (folate)/B12 (cobalamin) deficiency is known to induce brain structural and/or functional retardations. In many countries, folate supplementation,…”
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Glucocorticoid Receptor Activation Restores Learning Memory by Modulating Hippocampal Plasticity in a Mouse Model of Brain Vitamin B12 Deficiency by Dreumont, Natacha, Mimoun, Khalid, Pourié, Carine, Quadros, Edward V., Alberto, Jean-Marc, Umoret, Rémy, Helle, Déborah, Robert, Aurélie, Daval, Jean-Luc, Guéant, Jean-Louis, Pourié, Grégory

“…Cobalamin (Cbl, vitamin B 12 ) deficiency or inborn errors of Cbl metabolism can produce neurologic disorders resistant to therapies, including cognitive…”
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Developmental Impairments in a Rat Model of Methyl Donor Deficiency: Effects of a Late Maternal Supplementation with Folic Acid by Geoffroy, Andréa, Saber-Cherif, Lynda, Pourié, Grégory, Helle, Déborah, Umoret, Rémy, Guéant, Jean-Louis, Bossenmeyer-Pourié, Carine, Daval, Jean-Luc

“…Vitamins B9 (folate) and B12 act as methyl donors in the one-carbon metabolism which influences epigenetic mechanisms. We previously showed that an embryofetal…”
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The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9-12 Vitamins by Pourié, Grégory, Martin, Nicolas, Daval, Jean-Luc, Alberto, Jean-Marc, Umoret, Rémy, Guéant, Jean-Louis, Bossenmeyer-Pourié, Carine

“…A deficiency in B-vitamins is known to lead to persistent developmental defects in various organs during early life. The nervous system is particularly…”
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Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase by Guéant, Jean-Louis, Caillerez-Fofou, Maatem, Battaglia-Hsu, Shyuefang, Alberto, Jean-Marc, Freund, Jean-Noel, Dulluc, Isabelle, Adjalla, Charles, Maury, Florence, Merle, Carole, Nicolas, Jean-Pierre, Namour, Fares, Daval, Jean-Luc

“…Vitamin B12 (cobalamin, cbl) is a cofactor of methionine synthase (MTR) in the synthesis of methionine, the precursor of the universal methyl donor…”
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Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus by Saber Cherif, Lynda, Pourié, Grégory, Geoffroy, Andréa, Julien, Amélia, Helle, Déborah, Robert, Aurélie, Umoret, Rémy, Guéant, Jean-Louis, Bossenmeyer-Pourié, Carine, Daval, Jean-Luc

“…The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence…”
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Gestational Vitamin B Deficiency Leads to Homocysteine-Associated Brain Apoptosis and Alters Neurobehavioral Development in Rats by Blaise, Sébastien A, Nédélec, Emmanuelle, Schroeder, Henri, Alberto, Jean-Marc, Bossenmeyer-Pourié, Carine, Guéant, Jean-Louis, Daval, Jean-Luc

“…Hyperhomocysteinemia has been identified as a risk factor for neurological disorders. To study the influence of early deficiency in nutritional determinants of…”
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Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE by Battaglia-Hsu, Shyue-fang, Akchiche, Nassila, Noel, Nicole, Alberto, Jean-Marc, Jeannesson, Elise, Orozco-Barrios, Carlos Enrique, Martinez-Fong, Daniel, Daval, Jean-Luc, Guéant, Jean-Louis

“…Vitamin B12 (cobalamin, Cbl) is indispensable for proper brain development and functioning, suggesting that it has neurotrophic effects beside its well-known…”
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Non-injurious neonatal hypoxia confers resistance to brain senescence in aged male rats by Martin, Nicolas, Bossenmeyer-Pourié, Carine, Koziel, Violette, Jazi, Rozat, Audonnet, Sandra, Vert, Paul, Guéant, Jean-Louis, Daval, Jean-Luc, Pourié, Grégory

“…Whereas brief acute or intermittent episodes of hypoxia have been shown to exert a protective role in the central nervous system and to stimulate neurogenesis,…”
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Methyl Donor Deficiency Affects Fetal Programming of Gastric Ghrelin Cell Organization and Function in the Rat by Bossenmeyer-Pourié, Carine, Blaise, Sébastien, Pourié, Grégory, Tomasetto, Catherine, Audonnet, Sandra, Ortiou, Sandrine, Koziel, Violette, Rio, Marie-Christine, Daval, Jean-Luc, Guéant, Jean-Louis, Beck, Bernard

“…Methyl donor deficiency (MDD) during pregnancy influences intrauterine development. Ghrelin is expressed in the stomach of fetuses and influences fetal growth,…”
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Vitamin B12-Impaired Metabolism Produces Apoptosis and Parkinson Phenotype in Rats Expressing the Transcobalamin-Oleosin Chimera in Substantia Nigra by Orozco-Barrios, Carlos Enrique, Battaglia-Hsu, Shyue-Fang, Arango-Rodriguez, Martha Ligia, Ayala-Davila, Jose, Chery, Celine, Alberto, Jean-Marc, Schroeder, Henry, Daval, Jean-Luc, Martinez-Fong, Daniel, Gueant, Jean-Louis

“…Background: Vitamin B12 is indispensable for proper brain functioning and cytosolic synthesis of S-adenosylmethionine. Whether its deficiency produces effects…”
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Differentiation and neural integration of hippocampal neuronal progenitors: Signaling pathways sequentially involved by Akchiche, Nassila, Bossenmeyer-Pourié, Carine, Pourié, Grégory, Koziel, Violette, Nédélec, Emmanuelle, Guéant, Jean-Louis, Daval, Jean-Luc

“…In the context of their potential implication in regenerative strategies, we characterized cell mechanisms underlying the fate of embryonic rat hippocampal…”
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Bilirubin Induces Apoptosis via Activation of NMDA Receptors in Developing Rat Brain Neurons by Grojean, Stéphanie, Koziel, Violette, Vert, Paul, Daval, Jean-Luc

“…Increased amounts of bilirubin, the end product of heme degradation, are known to be detrimental to the central nervous system, especially in preterm newborns…”
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Conditioning-like Brief Neonatal Hypoxia Improves Cognitive Function and Brain Tissue Properties with Marked Gender Dimorphism in Adult Rats by Martin, Nicolas, Pourié, Grégory, PhD, Bossenmeyer-Pourié, Carine, PhD, Jazi, Rozat, PhD, Guéant, Jean-Louis, MD, PhD, Vert, Paul, MD, Daval, Jean-Luc, PhD

“…Although recent studies have documented compensatory generation of neurons in adult brains in response to various insults, a noninjurious short episode of…”
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Vitamin B deficiency causes neural cell loss and cognitive impairment in the developing rat by Daval, Jean-Luc, Blaise, Sébastien, Guéant, Jean-Louis

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Late Maternal Folate Supplementation Rescues from Methyl Donor Deficiency-Associated Brain Defects by Restoring Let-7 and miR-34 Pathways by Geoffroy, Andréa, Kerek, Racha, Pourié, Grégory, Helle, Déborah, Guéant, Jean-Louis, Daval, Jean-Luc, Bossenmeyer-Pourié, Carine

“…The micronutrients folate and vitamin B12 are essential for the proper development of the central nervous system, and their deficiency during pregnancy has…”
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