relationship between folate and docosahexaenoic acid in men

Objective: Docosahexaenoic acid (DHA, 22:6n-3), an essential omega 3 fatty acid, may protect against disorders of emotional regulation as well as cardiovascular disease. Animal studies demonstrate that dietary folate can increase tissue concentrations of DHA, although the literature, to date, includ...

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Published in:	European journal of clinical nutrition Vol. 60; no. 3; pp. 352 - 357
Main Authors:	Umhau, J.C, Dauphinais, K.M, Patel, S.H, Nahrwold, D.A, Hibbeln, J.R, Rawlings, R.R, George, D.T
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing 01-03-2006 Nature Publishing Group
Subjects:	Adult aggression Aggression - physiology Alcohol abuse Alcoholic beverages Alcoholism Animal diseases Biological and medical sciences blood lipids Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Case-Control Studies Correlation analysis Disorders Docosahexaenoic acid Docosahexaenoic Acids - blood Domestic Violence Drug abuse Emotions Erythrocytes Erythrocytes - chemistry essential fatty acids Fatty acids Fish oils Folic acid Folic Acid - administration & dosage Folic Acid - blood Food, Fortified hostility human behavior human nutrition Humans Male Medical sciences Men Mental disorders Metabolic diseases nutrient-nutrient interactions Nutrients nutritional status Pathogenesis Plasma polyunsaturated fatty acids Retrospective Studies Vitamin B United States Human RBC folate Nutrition Enzyme Transferases Vitamin Lipids Male n-3 fatty acids Docosahexaenoic acid n-3 fatty acid phosphatidylethanolamine-N-methyltransferase Folic acid Folate Methyltransferases Unsaturated fatty acid Phosphatidylethanolamine N-methyltransferase
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Summary:	Objective: Docosahexaenoic acid (DHA, 22:6n-3), an essential omega 3 fatty acid, may protect against disorders of emotional regulation as well as cardiovascular disease. Animal studies demonstrate that dietary folate can increase tissue concentrations of DHA, although the literature, to date, includes no human studies examining the possibility that folate status may affect plasma DHA concentrations. The objective of this study is to determine if the blood concentrations of folate and DHA are correlated in humans. Design: Retrospective study. Setting: An American research hospital. Subjects: A total of 15 normal and 22 hostile and aggressive subjects, with a mean age of 38 years. Methods: Concentrations of plasma polyunsaturated essential fatty acids and red blood cell folate (RBC folate) were obtained prior to 1996, before American flour was enriched with folate. Results: RBC folate was significantly correlated with plasma DHA, r=0.57, P=0.005 in the aggressive group. Age, smoking and alcohol consumption did not alter the results. No other essential fatty acids were significantly associated with RBC folate in either group. Conclusions: The positive relationship between plasma DHA and RBC folate concentrations suggests that these two nutrients should be examined together in order to make the most accurate inferences about their relative contributions to disease pathogenesis. Our findings present one explanation why some conditions associated with hostility and low DHA status, such as cardiovascular disease and emotional disorders, are also associated with low folate status. Sponsorship: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism.
Bibliography:	http://dx.doi.org/10.1038/sj.ejcn.1602321 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0954-3007 1476-5640
DOI:	10.1038/sj.ejcn.1602321