Search Results - "Dauphin, Michel"

Rapid Generation of Stable Transgenic Embryonic Stem Cell Lines Using Modular Lentivectors by Suter, David M., Cartier, Laetitia, Bettiol, Esther, Tirefort, Diderik, Jaconi, Marisa E., Dubois‐Dauphin, Michel, Krause, Karl‐Heinz

“…Generation of stable transgenic embryonic stem (ES) cell lines by classic transfection is still a difficult task, requiring time‐consuming clonal selection,…”
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The long-term survival of in vitro engineered nervous tissue derived from the specific neural differentiation of mouse embryonic stem cells by Dubois-Dauphin, Michel L, Toni, Nicolas, Julien, Stéphanie D, Charvet, Igor, Sundstrom, Lars E, Stoppini, Luc

“…Abstract Embryonic stem cells (ESCs) offer attractive prospective as potential source of neurons for cell replacement therapy in human neurodegenerative…”
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Development of Human Nervous Tissue upon Differentiation of Embryonic Stem Cells in Three‐Dimensional Culture by Preynat‐Seauve, Olivier, Suter, David M., Tirefort, Diderik, Turchi, Laurent, Virolle, Thierry, Chneiweiss, Herve, Foti, Michelangelo, Lobrinus, Johannes‐Alexander, Stoppini, Luc, Feki, Anis, Dubois‐Dauphin, Michel, Krause, Karl Heinz

“…Researches on neural differentiation using embryonic stem cells (ESC) require analysis of neurogenesis in conditions mimicking physiological cellular…”
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COB231 targets amyloid plaques in post‐mortem human brain tissue and in an Alzheimer mouse model by Garin, Dominique, Virgone‐Carlotta, Angélique, Gözel, Bülent, Oukhatar, Fatima, Perret, Pascale, Marti‐Battle, Danièle, Touret, Monique, Millet, Philippe, Dubois‐Dauphin, Michel, Meyronet, David, Streichenberger, Nathalie, Laferla, Frank M., Demeunynck, Martine, Chierici, Sabine, Sallanon, Marcelle Moulin, Ghezzi, Catherine

“…Previous works have shown the interest of naturally fluorescent proflavine derivatives to label Abeta deposits in vitro. This study aimed to further…”
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NOX3, a Superoxide-generating NADPH Oxidase of the Inner Ear by Bánfi, Botond, Malgrange, Brigitte, Knisz, Judit, Steger, Klaus, Dubois-Dauphin, Michel, Krause, Karl-Heinz

“…Reactive oxygen species (ROS) play a major role in drug-, noise-, and age-dependent hearing loss, but the source of ROS in the inner ear remains largely…”
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Cellular diversity within embryonic stem cells: pluripotent clonal sublines show distinct differentiation potential by Martinez, Yannick, Béna, Frédérique, Gimelli, Stefania, Tirefort, Diderik, Dubois‐Dauphin, Michel, Krause, Karl‐Heinz, Preynat‐Seauve, Olivier

“…Embryonic stem cells (ESC), derived from the early inner cell mass (ICM), are constituted of theoretically homogeneous pluripotent cells. Our study was…”
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The NADPH oxidase NOX2 controls glutamate release: a novel mechanism involved in psychosis-like ketamine responses by Sorce, Silvia, Schiavone, Stefania, Tucci, Paolo, Colaianna, Marilena, Jaquet, Vincent, Cuomo, Vincenzo, Dubois-Dauphin, Michel, Trabace, Luigia, Krause, Karl-Heinz

“…Subanesthetic doses of NMDA receptor antagonist ketamine induce schizophrenia-like symptoms in humans and behavioral changes in rodents. Subchronic…”
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Bax and Bcl‐2 Interaction in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis by Vukosavic, Slobodanka, Dubois‐Dauphin, Michel, Romero, Norma, Przedborski, Serge

“…: It has been proposed that mutations in copper/zinc‐superoxide dismutase (SOD1), the only proven cause of amyotrophic lateral sclerosis (ALS), induce the…”
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The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior by Lopez-Molina, Luis, Conquet, François, Dubois-Dauphin, Michel, Schibler, Ueli

“…DBP, a PAR leucine zipper transcription factor, accumulates according to a robust circadian rhythm in liver and several other tissues of mouse and rat. Here we…”
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Caspase‐related apoptosis in chronic ischaemic microangiopathy following experimental vein occlusion in mini‐pigs by Donati, Guy, Kapetanios, Anastasios, Dubois‐Dauphin, Michel, Pournaras, Constantin Jean

“… Purpose:  Acute brain ischaemia (stroke) causes a central area of coagulation necrosis. Peripheral to it and after a few hours, apoptosis causes neurons…”
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Fate of undifferentiated mouse embryonic stem cells within the rat heart: role of myocardial infarction and immune suppression by He, Qing, Trindade, Pedro T., Stumm, Michael, Li, Jian, Zammaretti, Prisca, Bettiol, Esther, Dubois‐Dauphin, Michel, Herrmann, François, Kalangos, Afksendyios, Morel, Denis, Jaconi, Marisa E.

“…It has recently been suggested that the infarcted rat heart microenvironment could direct pluripotent mouse embryonic stem cells to differentiate into…”
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A key role for the microglial NADPH oxidase in APP-dependent killing of neurons by Qin, Bin, Cartier, Laetitia, Dubois-Dauphin, Michel, Li, Bin, Serrander, Lena, Krause, Karl-Heinz

“…Reactive oxygen species (ROS) and deposition of cleaved products of amyloid precursor protein (APP) are thought to contribute to neuronal loss observed in…”
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Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases by Cartier, Laetitia, Hartley, Oliver, Dubois-Dauphin, Michel, Krause, Karl-Heinz

“…Chemokines were originally described as chemotactic cytokines involved in leukocyte trafficking. Research over the last decade, however, has shown that…”
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Stem Cell―Derived Neurons Grafted in the Striatum Are Expelled Out of the Brain After Chronic Cortical Stroke by DUBOIS-DAUPHIN, Michel, JULIEN, Stéphanie

“…In humans and rodents, cortical stroke can lead to cortex atrophy in long-term survivors. In the rodent, fetal brain neural precursors or stem cell-derived…”
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Sequential activation of individual caspases, and of alterations in Bcl‐2 proapoptotic signals in a mouse model of Huntington's disease by Zhang, Yu, Ona, Victor O., Li, Mingwei, Drozda, Martin, Dubois‐Dauphin, Michel, Przedborski, Serge, Ferrante, Robert J., Friedlander, Robert M.

“…Caspases play an important role in neurodegeneration in Huntington's disease (HD). Members of the Bcl‐2 family are critical modulators of terminal cell death…”
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Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis by Kostic, Vladimir, Jackson-Lewis, Vernice, de Bilbao, Fabienne, Dubois-Dauphin, Michel, Przedborski, Serge

“…Mutations in the gene encoding copper/zinc superoxide dismutase enzyme produce an animal model of familial amyotrophic lateral sclerosis (FALS), a fatal…”
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NOX4 Expression in Human Microglia Leads to Constitutive Generation of Reactive Oxygen Species and to Constitutive IL-6 Expression by Li, Bin, Bedard, Karen, Sorce, Silvia, Hinz, Boris, Dubois-Dauphin, Michel, Krause, Karl-Heinz

“…Reactive oxygen species (ROS) generation by microglia is implicated in neuroinflammation and neurotoxicity, as well as in host defense, cell proliferation and…”
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Elimination of proliferating cells from CNS grafts using a Ki67 promoter-driven thymidine kinase by Tieng, Vannary, Cherpin, Ophelie, Gutzwiller, Eveline, Zambon, Alexander C, Delgado, Christophe, Salmon, Patrick, Dubois-Dauphin, Michel, Krause, Karl-Heinz

“…Pluripotent stem cell (PSC)-based cell therapy is an attractive concept for neurodegenerative diseases, but can lead to tumor formation. This is particularly…”
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Delaying Caspase Activation by Bcl-2: A Clue to Disease Retardation in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis by Vukosavic, Slobodanka, Stefanis, Leonidas, Jackson-Lewis, Vernice, Guegan, Christelle, Romero, Norma, Chen, Caiping, Dubois-Dauphin, Michel, Przedborski, Serge

“…Molecular mechanisms of apoptosis may participate in motor neuron degeneration produced by mutant copper/zinc superoxide dismutase (mSOD1), the only proven…”
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Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia by Martinou, J C, Dubois-Dauphin, M, Staple, J K, Rodriguez, I, Frankowski, H, Missotten, M, Albertini, P, Talabot, D, Catsicas, S, Pietra, C

“…Naturally occurring cell death (NOCD) is a prominent feature of the developing nervous system. During this process, neurons express bcl-2, a major regulator of…”
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