Search Results - "Daumova, Lenka"

MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells by Golovina, Elena, Heizer, Tomas, Daumova, Lenka, Bajecny, Martin, Fontana, Simona, Griggio, Valentina, Jones, Rebecca, Coscia, Marta, Riganti, Chiara, Savvulidi Vargova, Karina

“…Hypoxia represents one of the key factors that stimulates the growth of leukemic cells in their niche. Leukemic cells in hypoxic conditions are forced to…”
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3,5,7-Substituted Pyrazolo[4,3‑d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models by Jorda, Radek, Havlíček, Libor, Šturc, Antonín, Tušková, Diana, Daumová, Lenka, Alam, Mahmudul, Škerlová, Jana, Nekardová, Michaela, Peřina, Miroslav, Pospíšil, Tomáš, Široká, Jitka, Urbánek, Lubor, Pachl, Petr, Řezáčová, Pavlína, Strnad, Miroslav, Klener, Pavel, Kryštof, Vladimír

“…Cyclin-dependent kinases are therapeutic targets frequently deregulated in various cancers. By convenient alkylation of the 5-sulfanyl group, we synthesized…”
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Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging by Etrych, Tomáš, Daumová, Lenka, Pokorná, Eva, Tušková, Diana, Lidický, Ondřej, Kolářová, Věra, Pankrác, Jan, Šefc, Luděk, Chytil, Petr, Klener, Pavel

“…In this study, we report the in vivo anti-lymphoma efficacy and diagnostic potential of newly designed near-infrared fluorescent dye containing…”
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Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways by Minařík, Lubomír, Pimková, Kristýna, Kokavec, Juraj, Schaffartziková, Adéla, Vellieux, Fréderic, Kulvait, Vojtěch, Daumová, Lenka, Dusilková, Nina, Jonášová, Anna, Vargová, Karina Savvulidi, Králová Viziová, Petra, Sedláček, Radislav, Zemanová, Zuzana, Stopka, Tomáš

“…The mechanisms by which myelodysplastic syndrome (MDS) cells resist the effects of hypomethylating agents (HMA) are currently the subject of intensive…”
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Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies by Bettazova, Nardjas, Senavova, Jana, Kupcova, Kristyna, Sovilj, Dana, Rajmonova, Anezka, Andera, Ladislav, Svobodova, Karla, Berkova, Adela, Zemanova, Zuzana, Daumova, Lenka, Herman, Vaclav, Dolníkova, Alexandra, Davis, R. Eric, Trneny, Marek, Klener, Pavel, Havranek, Ondrej

“…•PIK3CA gain and PTEN loss decrease the dependence of MCL cells on BCR signaling and antiapoptotic BCL2.•PIK3CA gain and PTEN loss lead to complex metabolic…”
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biomarker Driven Strategies for Targeted Elimination of Hypoxia Adapted Lymphoma Cells by Klener, Pavel, Daumová, Lenka, Kazantsev, Dmitry, Anděra, Ladislav, Petrák, Jiří, Dolníková, Alexandra, Bettazová, Nardjas, Kovaříková, Petra, Renešová, Nicol, Tušková, Liliana, Sovilj, Dana, Trněný, Marek, Klanova, Magdalena, Havránek, Ondrej

“…Large body of evidence suggests that hypoxia drives aggressive molecular features irrespective of cancer type. Non-Hodgkin lymphomas (NHL) are the most common…”
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