Search Results - "Daughdrill, Gary W."

Classification of Intrinsically Disordered Regions and Proteins by van der Lee, Robin, Buljan, Marija, Lang, Benjamin, Weatheritt, Robert J, Daughdrill, Gary W, Dunker, A. Keith, Fuxreiter, Monika, Gough, Julian, Gsponer, Joerg, Jones, David T, Kim, Philip M, Kriwacki, Richard W, Oldfield, Christopher J, Pappu, Rohit V, Tompa, Peter, Uversky, Vladimir N, Wright, Peter E, Babu, M. Madan

“…The authors examine the classification of intrinsically disordered regions and proteins…”
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Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding by He, Fan, Borcherds, Wade, Song, Tanjing, Wei, Xi, Das, Mousumi, Chen, Lihong, Daughdrill, Gary W., Chen, Jiandong

“…The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcription to regulate cell survival and proliferation. Dynamic…”
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Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells by Borcherds, Wade, Theillet, François-Xavier, Katzer, Andrea, Finzel, Ana, Mishall, Katie M, Powell, Anne T, Wu, Hongwei, Manieri, Wanda, Dieterich, Christoph, Selenko, Philipp, Loewer, Alexander, Daughdrill, Gary W

“…Increasing residual helicity in the p53 transcriptional activation domain strengthened interactions with Mdm2, resulting in alterations in p53 protein…”
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Sequence Properties of An Intramolecular Interaction That Inhibits p53 DNA Binding by Gregory, Emily, Daughdrill, Gary W

“…An intramolecular interaction between the p53 transactivation and DNA binding domains inhibits DNA binding. To study this autoinhibition, we used a fragment of…”
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Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex by Crabtree, Michael D, Borcherds, Wade, Poosapati, Anusha, Shammas, Sarah L, Daughdrill, Gary W, Clarke, Jane

“…Appropriate integration of cellular signals requires a delicate balance of ligand–target binding affinities. Increasing the level of residual structure in…”
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Uncoupling the Folding and Binding of an Intrinsically Disordered Protein by Poosapati, Anusha, Gregory, Emily, Borcherds, Wade M., Chemes, Lucia B., Daughdrill, Gary W.

“…The relationship between helical stability and binding affinity was examined for the intrinsically disordered transactivation domain of the myeloblastosis…”
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Autoinhibition of MDMX by intramolecular p53 mimicry by Chen, Lihong, Borcherds, Wade, Wu, Shaofang, Becker, Andreas, Schonbrunn, Ernst, Daughdrill, Gary W., Chen, Jiandong

“…The p53 inhibitor MDMX is controlled by multiple stress signaling pathways. Using a proteolytic fragment release (PFR) assay, we detected an intramolecular…”
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Shifts in the host range of a promiscuous plasmid through parallel evolution of its replication initiation protein by Sota, Masahiro, Yano, Hirokazu, M Hughes, Julie, Daughdrill, Gary W, Abdo, Zaid, Forney, Larry J, Top, Eva M

“…The ability of bacterial plasmids to adapt to novel hosts and thereby shift their host range is key to their long-term persistence in bacterial communities…”
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Conserved Glycines Control Disorder and Function in the Cold-Regulated Protein, COR15A by Sowemimo, Oluwakemi T, Knox-Brown, Patrick, Borcherds, Wade, Rindfleisch, Tobias, Thalhammer, Anja, Daughdrill, Gary W

“…Cold-regulated (COR) 15A is an intrinsically disordered protein (IDP) from important for freezing tolerance. During freezing-induced cellular dehydration,…”
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Modeling the accessible conformations of the intrinsically unstructured transactivation domain of p53 by Lowry, David F., Stancik, Amber, Shrestha, Ranjay Mann, Daughdrill, Gary W.

“…Internuclear distances derived from paramagnetic relaxation enhancement (PRE) data were used to restrain molecular dynamics simulations of the intrinsically…”
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Dynamic Behavior of an Intrinsically Unstructured Linker Domain Is Conserved in the Face of Negligible Amino Acid Sequence Conservation by Daughdrill, Gary W, Narayanaswami, Pranesh, Gilmore, Sara H, Belczyk, Agniezka, Brown, Celeste J

“…Proteins or regions of proteins that do not form compact globular structures are classified as intrinsically unstructured proteins (IUPs). IUPs are common in…”
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Disorder predictors also predict backbone dynamics for a family of disordered proteins by Daughdrill, Gary W, Borcherds, Wade M, Wu, Hongwei

“…Several algorithms have been developed that use amino acid sequences to predict whether or not a protein or a region of a protein is disordered. These…”
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Disorder for Dummies: Functional Mutagenesis of Transient Helical Segments in Disordered Proteins by Daughdrill, Gary W

“…Most cytosolic eukaryotic proteins contain a mixture of ordered and disordered regions. Disordered regions facilitate cell signaling by concentrating sites for…”
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Understanding the structural ensembles of a highly extended disordered protein by Daughdrill, Gary W, Kashtanov, Stepan, Stancik, Amber, Hill, Shannon E, Helms, Gregory, Muschol, Martin, Receveur-Bréchot, Véronique, Ytreberg, F Marty

“…Developing a comprehensive description of the equilibrium structural ensembles for intrinsically disordered proteins (IDPs) is essential to understanding their…”
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Evolution and disorder by Brown, Celeste J, Johnson, Audra K, Dunker, A Keith, Daughdrill, Gary W

“…► Intrinsically disordered protein (IDP) evolves differently than ordered protein. ► IDPs have more gaps, different accepted mutations, and generally evolve…”
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Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding by Wei, Xi, Wu, Shaofang, Song, Tanjing, Chen, Lihong, Gao, Ming, Borcherds, Wade, Daughdrill, Gary W., Chen, Jiandong

“…The MDMX oncoprotein is an important regulator of tumor suppressor p53 activity during embryonic development. Despite sequence homology to the ubiquitin E3…”
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Conformational buffering underlies functional selection in intrinsically disordered protein regions by González-Foutel, Nicolás S., Glavina, Juliana, Borcherds, Wade M., Safranchik, Matías, Barrera-Vilarmau, Susana, Sagar, Amin, Estaña, Alejandro, Barozet, Amelie, Garrone, Nicolás A., Fernandez-Ballester, Gregorio, Blanes-Mira, Clara, Sánchez, Ignacio E., de Prat-Gay, Gonzalo, Cortés, Juan, Bernadó, Pau, Pappu, Rohit V., Holehouse, Alex S., Daughdrill, Gary W., Chemes, Lucía B.

“…Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging to identify the mechanisms responsible…”
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Using NMR Chemical Shifts to Determine Residue-Specific Secondary Structure Populations for Intrinsically Disordered Proteins by Borcherds, Wade M, Daughdrill, Gary W

“…Protein disorder is a pervasive phenomenon in biology and a natural consequence of polymer evolution that facilitates cell signaling by organizing sites for…”
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Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX by Borcherds, Wade, Becker, Andreas, Chen, Lihong, Chen, Jiandong, Chemes, Lucía B., Daughdrill, Gary W.

“…MdmX contains an intramolecular binding motif that mimics the binding of the p53 tumor suppressor. This intramolecular binding motif is connected to the p53…”
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Comparing Models of Evolution for Ordered and Disordered Proteins by Brown, Celeste J., Johnson, Audra K., Daughdrill, Gary W.

“…Most models of protein evolution are based upon proteins that form relatively rigid 3D structures. A significant fraction of proteins, the so-called disordered…”
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