Search Results - "Datta, Nabanita S"

Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis by JINHUI LIAO, SCHNEIDER, Abraham, DATTA, Nabanita S, MCCAULEY, Laurie K

“…Prostate cancer almost exclusively metastasizes to skeletal sites, indicating that the bone provides a favorable microenvironment for its localization and…”
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Parathyroid hormone-related peptide protects cardiomyocytes from oxidative stress-induced cell death: First evidence of a novel endocrine–cardiovascular interaction by Datta, Nabanita S., Chukkapalli, Sahiti, Vengalil, Nathan, Zhan, Enbo, Przyklenk, Karin, Lasley, Robert

“…Although there is a growing interest in the molecular cross-talk between the endocrine and cardiovascular systems, the cardiac effects of calcium-regulating…”
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Cyclin D1 as a Target for the Proliferative Effects of PTH and PTHrP in Early Osteoblastic Cells by Datta, Nabanita S, Pettway, Glenda J, Chen, Chen, Koh, Amy J, McCauley, Laurie K

“…PTHrP induced a proliferative cyclin D1 activation in low‐density osteoblastic cells. The process was PKA and MAPK dependent and involved both AP‐1 and CRE…”
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Distinct roles for mitogen-activated protein kinase phosphatase-1 (MKP-1) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation by Datta, Nabanita S., Kolailat, Rola, Fite, Alemu, Pettway, Glenda, Abou-Samra, Abdul B.

“…Parathyroid hormone (PTH) and PTH-related protein (PTHrP) activate one single receptor (PTH1R) which mediates catabolic and anabolic actions in the bone…”
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Cells of the Osteoclast Lineage as Mediators of the Anabolic Actions of Parathyroid Hormone in Bone by Koh, Amy J, Demiralp, Burak, Neiva, Kathleen G, Hooten, Joanna, Nohutcu, Rahime M, Shim, Hyunsuk, Datta, Nabanita S, Taichman, Russell S, McCauley, Laurie K

“…PTH is an anabolic agent used to treat osteoporosis, but its mechanisms of action are unclear. This study elucidated target cells and mechanisms for anabolic…”
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PTH and PTHrP signaling in osteoblasts by Datta, Nabanita S., Abou-Samra, Abdul B.

“…The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging…”
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Mitogen-activated protein kinase phosphatase 1 regulates bone mass, osteoblast gene expression, and responsiveness to parathyroid hormone by Mahalingam, Chandrika D, Datta, Tanuka, Patil, Rashmi V, Kreider, Jaclynn, Bonfil, R Daniel, Kirkwood, Keith L, Goldstein, Steven A, Abou-Samra, Abdul B, Datta, Nabanita S

“…Parathyroid hormone (PTH) signaling via PTH 1 receptor (PTH1R) involves mitogen-activated protein kinase (MAPK) pathways. MAPK phosphatase 1 (MKP1)…”
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Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 is Expressed inOsteoblasts and Regulated by PTH by Sharma, Sonali, Mahalingam, Chandrika D., Das, Varsha, Jamal, Shazia, Levi, Edi, Rishi, Arun K., Datta, Nabanita S.

“…•CARP-1 is identified for the first time in bone cells.•PTH downregulates CARP-1 expression in differentiated osteoblasts.•PTH displaces CARP-1 from nucleus to…”
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Role of Bcl2 in Osteoclastogenesis and PTH Anabolic Actions in Bone by Yamashita, Junro, Datta, Nabanita S, Chun, Yong‐Hee P, Yang, Dong‐Ye, Carey, Allison A, Kreider, Jaclynn M, Goldstein, Steven A, McCauley, Laurie K

“…Introduction: B‐cell leukemia/lymphoma 2 (Bcl2) is a proto‐oncogene best known for its ability to suppress cell death. However, the role of Bcl2 in the…”
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PTHrP Signaling Targets Cyclin D1 and Induces Osteoblastic Cell Growth Arrest by Datta, Nabanita S, Chen, Chen, Berry, Janice E, McCauley, Laurie K

“…PTHrP control of the MC3T3‐E1 cell cycle machinery showed that, during differentiation, PTHrP induced G1 growth arrest. Cyclin D1 was a critical mediator as a…”
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Role of PTH1R internalization in osteoblasts and bone mass using a phosphorylation-deficient knock-in mouse model by Datta, Nabanita S, Samra, Tareq A, Mahalingam, Chandrika D, Datta, Tanuka, Abou-Samra, Abdul B

“…Phosphorylation, internalization, and desensitization of G protein-coupled receptors, such as the parathyroid hormone (PTH) and PTH-related peptide (PTHrP)…”
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Rap1GAP Inhibits Tumor Growth in Oropharyngeal Squamous Cell Carcinoma by Zhang, Zhaocheng, Mitra, Raj S., Henson, Bradley S., Datta, Nabanita S., McCauley, Laurie K., Kumar, Pawan, Lee, Julia S.-J., Carey, Thomas E., D'Silva, Nisha J.

“…Rap1, a growth regulatory protein that is strongly expressed in human squamous cell carcinoma (SCC), is inactivated by rap1GAP. Recent evidence in normal rat…”
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Muscle–bone and fat–bone interactions in regulating bone mass: do PTH and PTHrP play any role? by Datta, Nabanita S.

“…Metabolic bone disease occurs when there is a net loss in bone density. Osteoporosis, the most common metabolic bone disease, is a devastating problem and an…”
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Impact of the Mitogen-activated Protein Kinase Pathway on Parathyroid Hormone-related Protein Actions in Osteoblasts by Chen, Chen, Koh, Amy J, Datta, Nabanita S, Zhang, Jian, Keller, Evan T, Xiao, Guozhi, Franceschi, Renny T, D'Silva, Nisha J, McCauley, Laurie K

“…Parathyroid hormone-related protein (PTHrP) regulates proliferation and differentiation of osteoblastic cells via binding to the parathyroid hormone receptor…”
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Parathyroid Hormone-Related Peptide: A Novel Endocrine Cardioprotective "Conditioning Mimetic" by Datta, Tanuka, Przyklenk, Karin, Datta, Nabanita S

“…An as-yet limited body of evidence suggests that calcium-regulating endocrine hormones-in particular, parathyroid hormone-related peptide (PTHrP)-may have…”
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JunB as a Downstream Mediator of PTHrP Actions in Cementoblasts by Berry, Janice E, Ealba, Erin L, Pettway, Glenda J, Datta, Nabanita S, Swanson, Erica C, Somerman, Martha J, McCauley, Laurie K

“…The role of AP‐1 family members in the action of PTHrP was examined in cementoblasts. PTHrP increased mRNA and protein levels of all Fos members, but only one…”
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Mitogen-activated protein kinase phosphatase-1: function and regulation in bone and related tissues by Broome, David T, Datta, Nabanita S

“…In this review, we have highlighted work that has clearly demonstrated that mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), a negative regulator…”
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Membrane Type I Matrix Metalloproteinase Usurps Tumor Growth Control Imposed by the Three-Dimensional Extracellular Matrix by Hotary, Kevin B, Allen, Edward D, Brooks, Peter C, Datta, Nabanita S, Long, Michael W, Weiss, Stephen J

“…Cancer cells are able to proliferate at accelerated rates within the confines of a three-dimensional (3D) extracellular matrix (ECM) that is rich in type I…”
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Parathyroid Hormone-Related Peptide and Its Analog, Abaloparatide, Attenuate Lethal Myocardial Ischemia-Reperfusion Injury by Wider, Joseph, Undyala, Vishnu V R, Lanske, Beate, Datta, Nabanita S, Przyklenk, Karin

“…Parathyroid hormone-related peptide (PTHrP) is well-known to play a role in bone formation, and abaloparatide, an analog of PTHrP(1-34), is approved for the…”
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PTHrP attenuates osteoblast cell death and apoptosis induced by a novel class of anti-cancer agents by Chukkapalli, Sahiti, Levi, Edi, Rishi, Arun K., Datta, Nabanita S.

“…The effectiveness of chemotherapeutic agents often limits their use due to their negative effects on normal cells. Apoptosis regulatory protein (CARP)-1…”
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