Search Results - "Datson, Nicole A"

Stress and corticosteroids regulate rat hippocampal mitochondrial DNA gene expression via the glucocorticoid receptor by Hunter, Richard G., Seligsohn, Ma’ayan, Rubin, Todd G., Griffiths, Brian B., Ozdemir, Yildirim, Pfaff, Donald W., Datson, Nicole A., McEwen, Bruce S.

“…Glucocorticoids (GCs) are involved in stress and circadian regulation, and produce many actions via the GC receptor (GR), which is classically understood to…”
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Use of capillary Western immunoassay (Wes) for quantification of dystrophin levels in skeletal muscle of healthy controls and individuals with Becker and Duchenne muscular dystrophy by Beekman, Chantal, Janson, Anneke A, Baghat, Aabed, van Deutekom, Judith C, Datson, Nicole A

“…Duchenne muscular dystrophy (DMD) is a neuromuscular disease characterized by progressive weakness of the skeletal and cardiac muscles. This X-linked disorder…”
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The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain by Datson, Nicole A, González-Barriga, Anchel, Kourkouta, Eleni, Weij, Rudie, van de Giessen, Jeroen, Mulders, Susan, Kontkanen, Outi, Heikkinen, Taneli, Lehtimäki, Kimmo, van Deutekom, Judith C T

“…The aim of these studies was to demonstrate the therapeutic capacity of an antisense oligonucleotide with the sequence (CUG)7 targeting the expanded CAG repeat…”
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Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response by Hunter, Richard G, Murakami, Gen, Dewell, Scott, Seligsohn, Ma’ayan, Baker, Miriam E. R, Datson, Nicole A, McEwen, Bruce S, Pfaff, Donald W

“…The hippocampus is a highly plastic brain region particularly susceptible to the effects of environmental stress; it also shows dynamic changes in epigenetic…”
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Two Populations of Glucocorticoid Receptor-Binding Sites in the Male Rat Hippocampal Genome by Polman, J. Annelies E, de Kloet, E. Ronald, Datson, Nicole A

“…In the present study, genomic binding sites of glucocorticoid receptors (GR) were identified in vivo in the rat hippocampus applying chromatin…”
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Genome-wide coexpression of steroid receptors in the mouse brain: Identifying signaling pathways and functionally coordinated regions by Mahfouz, Ahmed, Lelieveldt, Boudewijn P. F., Grefhorst, Aldo, van Weert, Lisa T. C. M., Mol, Isabel M., Sips, Hetty C. M., van den Heuvel, José K., Datson, Nicole A., Visser, Jenny A., Reinders, Marcel J. T., Meijer, Onno C.

“…Steroid receptors are pleiotropic transcription factors that coordinate adaptation to different physiological states. An important target organ is the brain,…”
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NeuroD Factors Discriminate Mineralocorticoid From Glucocorticoid Receptor DNA Binding in the Male Rat Brain by van Weert, Lisa T.C.M., Buurstede, Jacobus C., Mahfouz, Ahmed, Braakhuis, Pamela S.M., Polman, J. Annelies E., Sips, Hetty C.M., Roozendaal, Benno, Balog, Judit, de Kloet, E. Ronald, Datson, Nicole A., Meijer, Onno C.

“…In the limbic brain, mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) both function as receptors for the naturally occurring…”
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Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator by Zalachoras, Ioannis, Houtman, René, Atucha, Erika, Devos, Rene, Tijssen, Ans M. I., Hu, Pu, Lockey, Peter M., Datson, Nicole A., Belanoff, Joseph K., Lucassen, Paul J., Joëls, Marian, de Kloet, E. Ronald, Roozendaal, Benno, Hunt, Hazel, Meijer, Onno C.

“…Glucocorticoid receptor (GR) antagonism may be of considerable therapeutic value in stress-related psychopathology such as depression. However, blockade of all…”
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Previous History of Chronic Stress Changes the Transcriptional Response to Glucocorticoid Challenge in the Dentate Gyrus Region of the Male Rat Hippocampus by Datson, Nicole A, van den Oever, Jessica M.E, Korobko, Oksana B, Magarinos, Ana Maria, de Kloet, E. Ronald, McEwen, Bruce S

“…Chronic stress is a risk factor for several neuropsychiatric diseases, such as depression and psychosis. In response to stress glucocorticoids (GCs) are…”
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Digital Droplet PCR for the Absolute Quantification of Exon Skipping Induced by Antisense Oligonucleotides in (Pre-)Clinical Development for Duchenne Muscular Dystrophy by Verheul, Ruurd C, van Deutekom, Judith C T, Datson, Nicole A

“…Antisense oligonucleotides (AONs) in clinical development for Duchenne muscular dystrophy (DMD) aim to induce skipping of a specific exon of the dystrophin…”
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Epigenetic mechanisms in migraine: a promising avenue? by Eising, Else, A Datson, Nicole, van den Maagdenberg, Arn M J M, Ferrari, Michel D

“…Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms…”
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Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide by Kourkouta, Eleni, Weij, Rudie, González-Barriga, Anchel, Mulder, Melissa, Verheul, Ruurd, Bosgra, Sieto, Groenendaal, Bas, Puoliväli, Jukka, Toivanen, Jussi, van Deutekom, Judith C.T., Datson, Nicole A.

“…Spinocerebellar ataxia type 3 (SCA3) and type 1 (SCA1) are dominantly inherited neurodegenerative disorders that are currently incurable. Both diseases are…”
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A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells by Polman, J Annelies E, Welten, Jennifer E, Bosch, Danny S, de Jonge, Robert T, Balog, Judit, van der Maarel, Silvère M, de Kloet, E Ronald, Datson, Nicole A

“…Glucocorticoids, secreted by the adrenals in response to stress, profoundly affect structure and plasticity of neurons. Glucocorticoid action in neurons is…”
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Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History by Polman, J. Annelies E, Hunter, Richard G, Speksnijder, Niels, van den Oever, Jessica M.E, Korobko, Oksana B, McEwen, Bruce S, de Kloet, E. Ronald, Datson, Nicole A

“…Glucocorticoid (GC) hormones, released by the adrenals in response to stress, are key regulators of neuronal plasticity. In the brain, the hippocampus is a…”
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A multicenter comparison of quantification methods for antisense oligonucleotide-induced DMD exon 51 skipping in Duchenne muscular dystrophy cell cultures by Hiller, Monika, Falzarano, Maria Sofia, Garcia-Jimenez, Iker, Sardone, Valentina, Verheul, Ruurd C, Popplewell, Linda, Anthony, Karen, Ruiz-Del-Yerro, Estibaliz, Osman, Hana, Goeman, Jelle J, Mamchaoui, Kamel, Dickson, George, Ferlini, Alessandra, Muntoni, Francesco, Aartsma-Rus, Annemieke, Arechavala-Gomeza, Virginia, Datson, Nicole A, Spitali, Pietro

“…Duchenne muscular dystrophy is a lethal disease caused by lack of dystrophin. Skipping of exons adjacent to out-of-frame deletions has proven to restore…”
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Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression by Datson, Nicole A., Van Der Perk, Jeannette, De Kloet, E. Ronald, Vreugdenhil, Erno

“…Adrenal corticosteroids (CORT) have a profound effect on the function of the hippocampus. This is mediated in a coordinated manner by mineralocorticoid (MR)…”
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Flibanserin and 8‐OH‐DPAT Implicate Serotonin in Association between Female Marmoset Monkey Sexual Behavior and Changes in Pair‐Bond Quality by Aubert, Yves, Gustison, Morgan L., Gardner, Lindsey A., Bohl, Michael A., Lange, Jason R., Allers, Kelly A., Sommer, Bernd, Datson, Nicole A., Abbott, David H.

“…Psychopathological origins of personally distressing, hypoactive sexual desire disorder (HSDD) in women are unknown, but are generally attributed to an…”
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Antisense-mediated isoform switching of steroid receptor coactivator-1 in the central nucleus of the amygdala of the mouse brain by Zalachoras, Ioannis, Grootaers, Gwendolynn, van Weert, Lisa T C M, Aubert, Yves, de Kreij, Suzanne R, Datson, Nicole A, van Roon-Mom, Willeke M C, Aartsma-Rus, Annemieke, Meijer, Onno C

“…Antisense oligonucleotide (AON)-mediated exon skipping is a powerful tool to manipulate gene expression. In the present study we investigated the potential of…”
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Cloning and characterization of a novel bicoid -related homeobox transcription factor gene, RIEG , involved in Rieger syndrome by Alward, W. Lee M, Semina, Elena V, Small, Kent W, Datson, Nicole A, Siegel-Bartelt, Jacqueline, Murray, Jeffrey C, Bierke-Nelson, Diane, Reiter, Rebecca, Zabel, Bernhard U, Carey, John C, Bitoun, Pierre, Leysens, Nancy J

“…Rieger syndrome (RIEG) is an autosomal-dominant human disorder that includes anomalies of the anterior chamber of the eye, dental hypoplasia and a protuberant…”
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Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis by Evans, Simon J., Datson, Nicole A., Kabbaj, Mohamed, Thompson, Robert C., Vreugdenhil, Erno, De Kloet, E. Ronald, Watson, Stanley J., Akil, Huda

“…DNA microarrays are a powerful tool for monitoring thousands of transcript levels simultaneously. However, the use of DNA microarrays in studying the central…”
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