NO-generating neurons in the medullary cardiovascular centers of rodents and carnivores

The aim of the study was to characterize the species-related differences in the distribution of nitric oxide synthase (NOS)-containing neurons in rodents and carnivores medullary cardiovascular centers that take part in regulation of the sympathetic or parasympathetic drives. The order of the mean n...

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Published in:	Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Vol. 136; no. 3; pp. 605 - 612
Main Authors:	Maisky, Vladimir A., Datsenko, Vladimir V., Moibenko, Alexei A., Bugaychenko, Larisa A., Pilyavskii, Alexander I., Kostyukov, Alexander I., Kalezic, Ivana, Johansson, Håkan
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2003
Subjects:	Animals Cardiovascular centers Cardiovascular System - innervation Cat Cats Dog Dogs Medulla Oblongata - cytology Medulla Oblongata - metabolism NADP - metabolism NADPH Dehydrogenase - metabolism Neurons - enzymology Neurons - metabolism Nitric Oxide - biosynthesis Nitric oxide synthase Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Rat Rats Rats, Wistar Species Specificity DMV, dorsal motor nucleus of vagus 7-NI, 7-nitroindazole Rat NOS, nitric oxide synthase Cardiovascular centers NO, nitric oxide CVLM, caudal ventrolateral medulla Cat Nitric oxide synthase L-NNA, nitro- l-arginine NTS, nucleus tractus solitarius RVLM, rostral ventrolateral medulla Dog NADPH-d, nicotinamide adenine dinucleotide phosphate-diaphorase
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Summary:	The aim of the study was to characterize the species-related differences in the distribution of nitric oxide synthase (NOS)-containing neurons in rodents and carnivores medullary cardiovascular centers that take part in regulation of the sympathetic or parasympathetic drives. The order of the mean number of NOS-containing neurons in the dorsomedial and ventrolateral medulla (per section) in different animals was as follows: dog>cat>rat. Although the density of the positive cells in the both regions was changed in the following sequence: rat=cat>dog. Within the dorsal motor nucleus of vagus significant exceeding of the mean number and density of positive cells (preganglionic vagal neurons) in dog were found. Differences in the distribution of NO-generating neurons in the medullary cardiovascular centers and the heterogeneity in the basal level of NO release may contribute to the distinctive alterations of the hemodynamic reactions in the studied species after administration of NOS inhibitors.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1095-6433 1531-4332
DOI:	10.1016/S1095-6433(03)00214-9