Total synthesis of agomelatine via Friedel–Crafts acylation followed by Willgerodt–Kindler reaction

Total synthesis of agomelatine via Friedel–Crafts acylation followed by Willgerodt–Kindler reaction

Total synthesis of antidepressant drug, agomelatine is reported. Regio selective Friedel–Crafts acylation followed by Willgerodt–Kindler reactions is used as the key steps for the synthesis of agomelatine.

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Bibliographic Details
Published in:Tetrahedron letters Vol. 55; no. 29; pp. 3885 - 3887
Main Authors: Vujjini, Satish Kumar, Datla, V.R. Krishnam Raju, Badarla, Krishna Rao, Vetukuri, V.N.K.V. Prasada Raju, Bandichhor, Rakeshwar, Kagga, Mukkanti, Cherukupally, Praveen
Format: Journal Article
Language:English
Published: Elsevier Ltd 16-07-2014
Subjects:
Acylation
Agomelatine
Antidepressant drug
Antidepressants
Drugs
Friedel–Crafts acylation
Regio selectivity
Synthesis (chemistry)
Tetrahedrons
Willgerodt–Kindler reaction
Friedel–Crafts acylation
Regio selectivity
Agomelatine
Antidepressant drug
Willgerodt–Kindler reaction
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Summary:Total synthesis of antidepressant drug, agomelatine is reported. Regio selective Friedel–Crafts acylation followed by Willgerodt–Kindler reactions is used as the key steps for the synthesis of agomelatine.
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ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.03.106