Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model

Highlights • TRPM7 increases after injections of 6-hydroxydopamine into the striatum. • Carvacrol reduces the loss of dopaminergic neurons induced by 6-hydroxydopamine. • Caspase-3 upregulation after 6-hydroxydopamine is attenuated by carvacrol. • Asymmetrical use of the forelimbs after 6-hydroxydop...

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Bibliographic Details
Published in:	Neuroscience Vol. 356; pp. 176 - 181
Main Authors:	Dati, L.M, Ulrich, H, Real, C.C, Feng, Z.P, Sun, H.S, Britto, L.R
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 25-07-2017
Subjects:	Animals carvacrol Disease Models, Animal dopamine Male Mice, Inbred C57BL Monoterpenes - pharmacology Neurology Neurons - drug effects Neurons - metabolism neuroprotection Neuroprotection - drug effects Neuroprotective Agents - pharmacology Parkinson Disease - drug therapy Substantia Nigra - drug effects TRP channels analysis of variance ANOVA neuroprotection PFA SEM standard error of the mean carvacrol paraformaldehyde dopamine TRP channels
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Summary:	Highlights • TRPM7 increases after injections of 6-hydroxydopamine into the striatum. • Carvacrol reduces the loss of dopaminergic neurons induced by 6-hydroxydopamine. • Caspase-3 upregulation after 6-hydroxydopamine is attenuated by carvacrol. • Asymmetrical use of the forelimbs after 6-hydroxydopamine was reduced by carvacrol.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.05.013