Search Results - "Datar, Rajan"
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Circulating tumor cell assay to non-invasively evaluate PD-L1 and other therapeutic targets in multiple cancers
Published in PloS one (17-06-2022)“…Biomarker directed selection of targeted anti-neoplastic agents such as immune checkpoint inhibitors, small molecule inhibitors and monoclonal antibodies form…”
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Multi-analyte liquid biopsies for molecular pathway guided personalized treatment selection in advanced refractory cancers: A clinical utility pilot study
Published in Frontiers in oncology (23-12-2022)“…The selection of safe and efficacious anticancer regimens for treatment of patients with broadly refractory metastatic cancers remains a clinical challenge…”
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Development and validation of a multigene variant profiling assay to guide targeted and immuno therapy selection in solid tumors
Published in PloS one (08-02-2021)“…We present data on analytical validation of the multigene variant profiling assay (CellDx) to provide actionable indications for selection of targeted and…”
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Accurate prostate cancer detection based on enrichment and characterization of prostate cancer specific circulating tumor cells
Published in Cancer medicine (Malden, MA) (01-04-2023)“…Background The low specificity of serum PSA resulting in the inability to effectively differentiate prostate cancer from benign prostate conditions is a…”
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Tussle of tertiary testing laboratories amid the coronavirus disease-2019 crisis
Published in Cancer research, statistics, and treatment (Online) (01-01-2020)Get full text
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Response to pazopanib‐based combination regimen in a case of FGFR3 amplified gastric adenocarcinoma
Published in Clinical case reports (01-11-2021)“…Angiogenesis inhibitors (AGI) are not presently used for the treatment of gastric cancers. This report demonstrates that angiogenesis inhibitor can be safely…”
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Outcomes of personalized therapy guided by Exacta encyclopedic tumor analysis for women with broadly refractory advanced breast cancer
Published in Journal of clinical oncology (01-06-2024)“…e13124 Background: Following the failure of three lines of systemic treatments in breast cancers, Standard of Care guidelines typically recommend palliative…”
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Evaluation of survival outcomes in patients with solid organ cancer with brain metastasis treated with exacta encylopedic tumor analysis based treatments
Published in Journal of clinical oncology (01-06-2024)“…2033 Background: Brain metastasis in solid organ cancers presents a challenging scenario with an adverse prognosis and limited systemic treatment options…”
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Profiling of circulating glial cells for accurate blood‐based diagnosis of glial malignancies
Published in International journal of cancer (01-04-2024)“…Here, we describe a blood test for the detection of glial malignancies (GLI‐M) based on the identification of circulating glial cells (CGCs). The test is…”
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Enhancing cancer detection through AI-driven high content analysis of circulating tumor cells
Published in Journal of clinical oncology (01-06-2024)“…3054 Background: The advancements in automated High Content Analysis (HCA) for Circulating Tumor Cells (CTCs) detection necessitate the integration of…”
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Abstract P4-01-05: Circulating ensembles of tumor associated cells for detection of breast cancer
Published in Cancer research (Chicago, Ill.) (15-02-2020)“…Abstract Background: Mammographic screening for breast cancer offers the possibility of reducing morbidity and mortality from the disease but has economic and…”
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Accurate Screening for Early-Stage Breast Cancer by Detection and Profiling of Circulating Tumor Cells
Published in Cancers (09-07-2022)“…Background: The early detection of breast cancer (BrC) is associated with improved survival. We describe a blood-based breast cancer detection test based on…”
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Circulating ensembles of tumor‐associated cells: A redoubtable new systemic hallmark of cancer
Published in International journal of cancer (15-06-2020)“…Circulating ensembles of tumor‐associated cells (C‐ETACs) which comprise tumor emboli, immune cells and fibroblasts pose well‐recognized risks of thrombosis…”
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Abstract A49: Viable circulating ensembles of tumor-associated cells persist in pretreated patients with solid organ cancers showing no radiologically detectable disease
Published in Clinical cancer research (01-06-2020)“…Abstract The success of treatment in solid organ cancers is ascertained by radiologic imaging as per standard-of-care protocol, with PET-CT being the modality…”
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Abstract B15: Circulating tumor cells express tissue specific antigens in multiple cancers
Published in Clinical cancer research (01-06-2020)“…Abstract Definitive diagnosis of solid organ cancers is based on histopathologic analysis of tumor tissue obtained by invasive biopsies. However, invasive…”
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Abstract B17: An mRNA signature that accurately discerns gliomas from healthy individuals
Published in Clinical cancer research (01-06-2020)“…Abstract Diagnosis of suspected cases of gliomas such as intracranial space-occupying lesions (ICSOLs) is based on histopathologic analysis of tumor tissue…”
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Abstract B61: Encyclopedic noninvasive liquid biopsies for differential diagnosis in prostate cancer
Published in Clinical cancer research (01-06-2020)“…Abstract Differential diagnosis of prostatic adenocarcinomas is based on histopathologic analysis of tumor tissue obtained by transrectal ultrasound…”
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Abstract B16: Noninvasive liquid biopsies for guideline-compliant diagnostic assessment in ovarian cancers
Published in Clinical cancer research (01-06-2020)“…Abstract Diagnosis of ovarian adenocarcinomas is based on histopathologic analysis of tumor tissue obtained by invasive biopsies. However, invasive biopsies…”
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Addendum: A case report of androgen receptor inhibitor therapy in recurrent high-grade serous ovarian cancer
Published in Oncotarget (04-08-2022)Get full text
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