Search Results - "Dastugue, N"

IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951 by Clappier, E, Grardel, N, Bakkus, M, Rapion, J, De Moerloose, B, Kastner, P, Caye, A, Vivent, J, Costa, V, Ferster, A, Lutz, P, Mazingue, F, Millot, F, Plantaz, D, Plat, G, Plouvier, E, Poirée, M, Sirvent, N, Uyttebroeck, A, Yakouben, K, Girard, S, Dastugue, N, Suciu, S, Benoit, Y, Bertrand, Y, Cavé, H

“…The added value of IKZF1 gene deletion ( IKZF1 del ) as a stratifying criterion in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is still debated. We…”
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An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions by Clappier, E, Auclerc, M-F, Rapion, J, Bakkus, M, Caye, A, Khemiri, A, Giroux, C, Hernandez, L, Kabongo, E, Savola, S, Leblanc, T, Yakouben, K, Plat, G, Costa, V, Ferster, A, Girard, S, Fenneteau, O, Cayuela, J-M, Sigaux, F, Dastugue, N, Suciu, S, Benoit, Y, Bertrand, Y, Soulier, J, Cavé, H

“…Oncogenic subtypes in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are used for risk stratification. However, a significant number of…”
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RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation by Ballerini, P, Struski, S, Cresson, C, Prade, N, Toujani, S, Deswarte, C, Dobbelstein, S, Petit, A, Lapillonne, H, Gautier, E-F, Demur, C, Lippert, E, Pages, P, Mansat- De Mas, V, Donadieu, J, Huguet, F, Dastugue, N, Broccardo, C, Perot, C, Delabesse, E

“…Myeloproliferative neoplasms are frequently associated with aberrant constitutive tyrosine kinase (TK) activity resulting from chimaeric fusion genes or point…”
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NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951 by Clappier, E, Collette, S, Grardel, N, Girard, S, Suarez, L, Brunie, G, Kaltenbach, S, Yakouben, K, Mazingue, F, Robert, A, Boutard, P, Plantaz, D, Rohrlich, P, van Vlierberghe, P, Preudhomme, C, Otten, J, Speleman, F, Dastugue, N, Suciu, S, Benoit, Y, Bertrand, Y, Cavé, H

“…Risk-adjusted treatment stratification in T-cell acute lymphoblastic leukemias (T-ALLs) is currently based only on early response to chemotherapy. We…”
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Cytogenetics and outcome of allogeneic transplantation in first remission of acute myeloid leukemia: the French pediatric experience by Alloin, A-L, Leverger, G, Dalle, J-H, Galambrun, C, Bertrand, Y, Baruchel, A, Auvrignon, A, Gandemer, V, Ragu, C, Loundou, A, Bilhou-Nabera, C, Lafage-Pochitaloff, M, Dastugue, N, Nelken, B, Jubert, C, Rialland, F, Plat, G, Pochon, C, Vannier, J-P, Rohrlich, P-S, Kanold, J, Lutz, P, Sirvent, A, Oudin, C, Cuccuini, W, Michel, G

“…We analyzed the impact of cytogenetics on 193 children enrolled in two successive French trials (LAME89/91 and ELAM02), who received hematopoietic stem cell…”
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Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia: results of the EORTC CLG 58881 and 58951 trials by Piette, C, Suciu, S, Clappier, E, Bertrand, Y, Drunat, S, Girard, S, Yakouben, K, Plat, G, Dastugue, N, Mazingue, F, Grardel, N, van Roy, N, Uyttebroeck, A, Costa, V, Minckes, O, Sirvent, N, Simon, P, Lutz, P, Ferster, A, Pluchart, C, Poirée, M, Freycon, C, Dresse, M-F, Millot, F, Chantrain, C, van der Werff ten Bosch, J, Norga, K, Gilotay, C, Rohrlich, P-S, Benoit, Y, Cavé, H

“…In childhood B-cell precursor acute lymphoblastic leukaemias (BCP-ALL), the presence of an ETV6-RUNX1 fusion transcript defines one of the most prevalent…”
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PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study by Familiades, J, Bousquet, M, Lafage-Pochitaloff, M, Béné, M-C, Beldjord, K, De Vos, J, Dastugue, N, Coyaud, E, Struski, S, Quelen, C, Prade-Houdellier, N, Dobbelstein, S, Cayuela, J-M, Soulier, J, Grardel, N, Preudhomme, C, Cavé, H, Blanchet, O, Lhéritier, V, Delannoy, A, Chalandon, Y, Ifrah, N, Pigneux, A, Brousset, P, Macintyre, E A, Huguet, F, Dombret, H, Broccardo, C, Delabesse, É

“…Adult and child B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) differ in terms of incidence and prognosis. These disparities are mainly due to the…”
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Analyses of TET2 mutations in post-myeloproliferative neoplasm acute myeloid leukemias by Couronné, L, Lippert, E, Andrieux, J, Kosmider, O, Radford-Weiss, I, Penther, D, Dastugue, N, Mugneret, F, Lafage, M, Gachard, N, Nadal, N, Bernard, O A, Nguyen-Khac, F

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CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes by DIK, W. A, BRAHIM, W, BRAUN, C, ASNAFI, V, DASTUGUE, N, BERNARD, O. A, VAN DONGEN, J. M, LANGERAK, A. W, MACINTYRE, E. A, DELABESSE, E

“…The t(10;11)(p13;q14-21) is found in T-ALL and acute myeloid leukemia and fuses CALM (Clathrin-Assembly protein-like Lymphoid-Myeloid leukaemia gene) to AF10…”
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Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH) by Dastugue, Nicole, Lafage-Pochitaloff, Marina, Pagès, Marie-Pierre, Radford, Isabelle, Bastard, Christian, Talmant, Pascaline, Mozziconacci, Marie Joelle, Léonard, Claude, Bilhou-Nabéra, Christelle, Cabrol, Christine, Capodano, Anne-Marie, Cornillet-Lefebvre, Pascale, Lessard, Michel, Mugneret, Francine, Pérot, Christine, Taviaux, Sylvie, Fenneteaux, Odile, Duchayne, Eliane, Berger, Roland

“…To draw the cytogenetic profile of childhood and adult acute megakaryoblastic leukemia (M7), the Groupe Français de Cytogénétique Hématologique collected 53…”
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Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia by Graux, C, Stevens-Kroef, M, Lafage, M, Dastugue, N, Harrison, C J, Mugneret, F, Bahloula, K, Struski, S, Grégoire, M J, Nadal, N, Lippert, E, Taviaux, S, Simons, A, Kuiper, R P, Moorman, A V, Barber, K, Bosly, A, Michaux, L, Vandenberghe, P, Lahortiga, I, De Keersmaecker, K, Wlodarska, I, Cools, J, Hagemeijer, A, Poirel, H A

“…Episomes with the NUP214-ABL1 fusion gene have been observed in 6% of T-ALL. In this multicentric study we collected 27 cases of NUP214-ABL1 -positive T-ALL…”
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Long-term results of three randomized trials (58831, 58832, 58881) in childhood acute lymphoblastic leukemia : a CLCG-EORTC report by VILMER, E, SUCIU, S, MANEL, A.-M, ROBERT, A, NELKEN, B, MILLOT, F, LUTZ, P, RIALLAND, X, MECHINAUD, F, BOUTARD, P, BEHAR, C, CHANTRAINE, J-M, FERSTER, A, PLOUVIER, E, LAUREYS, G, BROCK, P, UYTTEBROECK, A, MARGUERITTE, G, PLANTAZ, D, NORTON, L, FRANCOTTE, N, GYSELINCK, J, WATERKEYN, C, BERTRAND, Y, SOLBU, G, PHILIPPE, N, OTTEN, J, CAVE, H, THYSS, A, BENOIT, Y, DASTUGUE, N, FOURNIER, M, SOUILLET, G

“…We present here the long-term results of three randomized clinical trials conducted on children with newly diagnosed acute lymphoblastic leukemia (ALL) between…”
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Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party by Grimwade, David, Biondi, Andrea, Mozziconacci, Marie-Joëlle, Hagemeijer, Anne, Berger, Roland, Neat, Michael, Howe, Kathy, Dastugue, Nicole, Jansen, Joop, Radford-Weiss, Isabelle, Coco, Francesco Lo, Lessard, Michel, Hernandez, Jesus-Maria, Delabesse, Eric, Head, David, Liso, Vincenzo, Sainty, Danielle, Flandrin, Georges, Solomon, Ellen, Birg, Françoise, Lafage-Pochitaloff, Marina

“…Acute promyelocytic leukemia (APL) is typified by the t(15;17), generating the PML-RARα fusion and predicting a beneficial response to retinoids. However, a…”
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Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRβ locus rearrangements and putative new T-cell oncogenes by CAUWELIER, B, DASTUGUE, N, COOLS, J, POPPE, B, HERENS, C, DE PAEPE, A, HAGEMEIJER, A, SPELEMAN, F

“…Chromosomal aberrations of T-cell receptor (TCR) gene loci often involve the TCRαδ (14q11) locus and affect various known T-cell oncogenes. A systematic…”
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A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias by SPELEMAN, F, CAUWELIER, B, BOOGAERTS, M, DE MOERLOOSE, B, BENOIT, Y, SELLESLAG, D, BILLIET, J, ROBERT, A, HUGUET, F, VANDENBERGHE, P, DE PAEPE, A, MARYNEN, P, DASTUGUE, N, HAGEMEIJER, A, COOLS, J, VERHASSELT, B, POPPE, B, VAN ROY, N, VANDESOMPELE, J, GRAUX, C, UYTTEBROECK, A

“…Chromosomal translocations with breakpoints in T-cell receptor (TCR) genes are recurrent in T-cell malignancies. These translocations involve the TCRalphadelta…”
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NUP98 rearrangements in hematopoietic malignancies : a study of the Groupe francophone de cytogénétique hématologique by ROMANA, S. P, RADFORD-WEISS, I, MOZZICONACCI, M.-J, ANDRIEU, J, LAI, J.-L, TERRE, C, RACK, K, CORNILLET-LEFEBVRE, P, LUQUET, I, NADAL, N, NGUYEN-KHAC, F, PEROT, C, BEN ABDELALI, R, VAN DEN AKKER, J, FERT-FERRER, S, CABROL, C, CHARRIN, C, TIGAUD, I, POIREL, H, VEKEMANS, M, BERNARD, O. A, BERGER, R, SCHLUTH, C, PETIT, A, DASTUGUE, N, TALMANT, P, BILHOU-NABERA, C, MUGNERET, F, LAFAGE-POCHITALOFF, M

“…The NUP98 gene is fused with 19 different partner genes in various human hematopoietic malignancies. In order to gain additional clinico-hematological data and…”
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High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21 by Preudhomme, Claude, Warot-Loze, Delphine, Roumier, Christophe, Grardel-Duflos, Nalthalie, Garand, Richard, Lai, Jean Luc, Dastugue, Nicole, Macintyre, Elizabeth, Denis, Claude, Bauters, Francis, Kerckaert, Jean Pierre, Cosson, Alain, Fenaux, Pierre

“…The AML1 gene, situated in 21q22, is often rearranged in acute leukemias through t(8;21) translocation, t(12;21) translocation, or less often t(3;21)…”
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Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia by TERRE, C, ECLACHE, V, DASTUGUE, N, TALMANT, P, VAN DEN AKKER, J, LEONARD, C, N'GUYEN KHAC, F, MUGNERET, F, VIGUIE, F, LAFAGE-POCHITALOFF, M, BASTIE, J. N, ROUX, G. L, ROUSSELOT, P, NICOLINI, F, MALOISEL, F, VEY, N, LAURENT, G, RECHER, C, VIGIER, M, YACOUBEN, Y, GIRAUDIER, S, VERNANT, J. P, SALLES, B, IMBERT, M, ROUSSI, J, CASTAIGNE, S, LEYMARIE, V, FLANDRIN, G, LESSARD, M, CHARRIN, C, GERVAIS, C, MOZZICONACCI, M. J, MAAREK, O, MOSSAFA, H, AUGER, N

“…Imatinib mesylate (Gleevec), an inhibitor of the BCR-ABL tyrosine kinase, was introduced recently into the therapy of chronic myeloid leukemia (CML). Several…”
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Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies by POPPE, Bruce, VANDESOMPELE, Jo, YIGIT, Nurten, DE PAEPE, Anne, HAGEMEIJER, Anne, SPELEMAN, Frank, SCHOCH, Claudia, LINDVALL, Charlotta, MROZEK, Krzysztof, BLOOMFIELD, Clara D, BEVERLOO, H. Berna, MICHAUX, Lucienne, DASTUGUE, Nicole, HERENS, Christian

“…MLL amplification was recently recognized as a recurrent aberration in acute myeloid leukemia (AML) and myelodys-plastic syndrome (MDS), associated with…”
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PAX5-AUTS2 fusion resulting from t(7;9)(q11.2;p13.2) can now be classified as recurrent in B cell acute lymphoblastic leukemia by Coyaud, E, Struski, S, Dastugue, N, Brousset, P, Broccardo, C, Bradtke, J

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