Search Results - "Dasso Lang, Maria Chiara"
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Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family
Published in Journal of medicinal chemistry (24-03-2016)“…Preventing HIV transmission by the use of a vaginal microbicide is a topic of considerable interest in the fight against AIDS. Both a potent anti-HIV agent and…”
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Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV‑1 Nucleocapsid Protein
Published in ACS medicinal chemistry letters (11-04-2019)“…Small molecule inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the…”
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Insights into the interaction of high potency inhibitor IRC‐083864 with phosphatase CDC25
Published in Proteins, structure, function, and bioinformatics (01-04-2017)“…ABSTRACT CDC25 phosphatases play a crucial role in cell cycle regulation. They have been found to be over‐expressed in various human tumours and to be valuable…”
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5,6-Dihydroxypyrimidine Scaffold to Target HIV‑1 Nucleocapsid Protein
Published in ACS medicinal chemistry letters (14-05-2020)“…The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a…”
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Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity
Published in Bioorganic & medicinal chemistry letters (01-12-2014)“…[Display omitted] Antibiotic resistance has reached alarming levels in many clinically-relevant human pathogens, and there is an increasing clinical need for…”
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Structure-Based Identification of HIV‑1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV‑1 Strains
Published in ACS chemical biology (19-01-2018)“…HIV/AIDS is still one of the leading causes of death worldwide. Current drugs that target the canonical steps of the HIV-1 life cycle are efficient in blocking…”
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Functional and Structural Characterization of 2‑Amino-4-phenylthiazole Inhibitors of the HIV‑1 Nucleocapsid Protein with Antiviral Activity
Published in ACS chemical biology (19-09-2014)“…The nucleocapsid protein (NC) is a highly conserved protein in diverse HIV-1 subtypes that plays a central role in virus replication, mainly by interacting…”
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Functional and Structural Characterization of 2-Amino-4-phenylthiazole Inhibitors of the HIV-1 Nucleocapsid Protein with Antiviral Activity
Published in ACS chemical biology (19-09-2014)“…The nucleocapsid protein (NC) is a highly conserved protein in diverse HIV-1 subtypes that plays a central role in virus replication, mainly by interacting…”
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Journal Article -
9
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N‑Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family
Published in Journal of medicinal chemistry (24-03-2016)“…Preventing HIV transmission by the use of a vaginal microbicide is a topic of considerable interest in the fight against AIDS. Both a potent anti-HIV agent and…”
Get full text
Journal Article