Search Results - "Dasilva, J N"

Kinetic model-based factor analysis of dynamic sequences for 82-rubidium cardiac positron emission tomography by Klein, R., Beanlands, R. S., Wassenaar, R. W., Thorn, S. L., Lamoureux, M., DaSilva, J. N., Adler, A., deKemp, R. A.

“…Purpose: Factor analysis has been pursued as a means to decompose dynamic cardiac PET images into different tissue types based on their unique temporal…”
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In Vivo Imaging of the Brain Vesicular Monoamine Transporter by Frey, K.A, Vander Borght, T.M, Killbourn, M.R, DaSilva, J.N, Carey, J.E, Kuhl, D.E

“…In the search for an in vivo marker of monoamine nerve terminal integrity, we investigated methoxytetrabenazine (MTBZ) as a tracer of the brain synaptic…”
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Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)γ₃ results in increased oxidative capacity and glucose uptake in human primary myotubes by Crawford, S. A, Costford, S. R, Aguer, C, Thomas, S. C, deKemp, R. A, DaSilva, J. N, Lafontaine, D, Kendall, M, Dent, R, Beanlands, R. S. B, McPherson, R, Harper, M.-E

“…Aims/hypothesis AMP-activated protein kinase (AMPK) has a broad role in the regulation of glucose and lipid metabolism making it a promising target in the…”
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Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes by Crawford, S A, Costford, S R, Aguer, C, Thomas, S C, deKemp, R A, DaSilva, J N, Lafontaine, D, Kendall, M, Dent, R, Beanlands, R S B, McPherson, R, Harper, M-E

“…AMP-activated protein kinase (AMPK) has a broad role in the regulation of glucose and lipid metabolism making it a promising target in the treatment of type 2…”
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In vivo evaluation of [ 11C]-and [ 18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography by Wilson, Alan A., DaSilva, Jean N., Houle, Sylvain

“…Four analogues of the potent dopamine transporter ligand, WIN 35,428, were radiolabelled with 11C and 18F at the 2-β-carboxy position for evaluation as…”
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Dysfunctional Attitudes and 5-HT2 Receptors During Depression and Self-Harm by Meyer, Jeffrey H., McMain, Shelley, Kennedy, Sidney H., Korman, Lorne, Brown, Gregory M., DaSilva, Jean N., Wilson, Alan A., Blak, Thomas, Eynan-Harvey, Rahel, Goulding, Verdell S., Houle, Sylvain, Links, Paul

“…OBJECTIVE: Dysfunctional attitudes are negatively biased assumptions and beliefs regarding oneself, the world, and the future. In healthy subjects, increasing…”
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Imaging 5-HT1A receptors with positron emission tomography: initial human studies with [11C]CPC-222 by Houle, S, Wilson, A A, Inaba, T, Fisher, N, DaSilva, J N

“…The novel radioligand [11C]CPC-222 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)-2-bicyclo [2,2,2]octane carboxamide) was evaluated as an in…”
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Derivatives of WAY 100635 as potential imaging agents for 5-HT1A receptors : Syntheses, radiosyntheses, and in vitro and in vivo evaluation by WILSON, A. A, INABA, T, FISCHER, N, DIXON, L. M, NOBREGA, J, DASILVA, J. N, HOULE, S

“…Analogues of the potent and selective 5-HT1A ligand, WAY 100635, were synthesized and examined as potential candidates for imaging 5-HT1A receptors by positron…”
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Neuromodulation of frontal and temporal cortex by intravenous d-fenfluramine : an [15O]H2O PET study in humans by MEYER, J. H, KAPUR, S, WILSON, A. A, DASILVA, J. N, HOULE, S, BROWN, G. M

“…This study assessed the modulatory effect of a serotonergic agonist, d-fenfluramine, on localized neuronal firing as indexed by changes in regional cerebral…”
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[18F]fluoroalkyl analogues of the potent 5-HT1A antagonist WAY 100635 : Radiosyntheses and In vivo evaluation by WILSON, A. A, DASILVA, J. N, HOULE, S

“…Two analogues of the potent 5-HT1A antagonist WAY 100635 have been synthesized and radiolabelled with 18F, namely N-[2-[4-(2-2'-[18F]…”
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An admonition when measuring the lipophilicity of radiotracers using counting techniques by Wilson, Alan A, Jin, Li, Garcia, Armando, DaSilva, Jean N, Houle, Sylvain

“…Log P measurements are a fundamental physico-chemical parameter and one of the cornerstones of structure–activity relationships in medicinal chemistry. Despite…”
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Characterization of [11C]tetrabenazine as an in vivo radioligand for the vesicular monoamine transporter by DaSilva, J N, Carey, J E, Sherman, P S, Pisani, T J, Kilbourn, M R

“…[11C]Tetrabenazine ([11C]TBZ) is a new in vivo radioligand for positron emission tomographic (PET) imaging of vesicular monoamine transporters. The in vivo…”
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Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders by Yoshinaga, Keiichiro, Chow, Benjamin J W, dekemp, Robert A, Thorn, Stephanie, Ruddy, Terrence D, Davies, Ross A, DaSilva, Jean N, Beanlands, Rob

“…The incidence of cardiovascular disease is increasing with the aging population. This has stimulated a need for innovative means to evaluate and develop…”
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Synthesis of a [11C]methoxy derivative of alpha-dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter by DaSilva, J N, Kilbourn, M R, Mangner, T J

“…The synthesis of [11C]TBZOMe, a [11C]methoxy derivative at the 2-hydroxy position of alpha-dihydrotetrabenazine, was carried out by an O-[11C]methylation…”
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Synthesis and structure-affinity of a series of 7α-undecylestradiol derivatives: a potential vector for therapy and imaging of estrogen-receptor-positive cancers by DASILVA, J. N, VAN LIER, J. E

“…A series of 7 alpha-undecylestradiol derivatives, featuring various substituents at the end of the undecyl spacer chain, were synthesized and evaluated for…”
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In vivo imaging of vesicular monoamine transporters in human brain using [11C]tetrabenazine and positron emission tomography by Kilbourn, M R, DaSilva, J N, Frey, K A, Koeppe, R A, Kuhl, D E

“…The pharmacokinetics of [11C]tetrabenazine, a high-affinity radioligand for the monoamine vesicular transporter, were determined in living human brain using in…”
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Dopamine D1 agonist R-[11C]SKF 82957 : Synthesis and in vivo characterization in rats by DASILVA, J. N, SCHWARTZ, R. A, GREENWALD, E. R, LOURENCO, C. M, WILSON, A. A, HOULE, S

“…The active enantiomer R-SKF 82957 was labeled with 11C by N-[11C]methylation of the full dopamine (D1) agonist R-SKF 81297, using [11C]methyl iodide in the…”
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Solid-phase radiosynthesis of [11C]WAY 100635 by Wilson, Alan A., DaSilva, Jean N., Houle, Sylvain

“…An efficient, fast and simple method is described for the radiosynthesis of the potent and selective 5‐HT1A antagonist…”
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In vivo binding of [11C]tetrabenazine to vesicular monoamine transporters in mouse brain by DaSilva, J N, Kilbourn, M R

“…The time course of regional mouse brain distribution of radioactivity after i.v. injection of a tracer dose of [11C]tetrabenazine ([11C]TBZ) has been…”
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Analogues of WAY 100635 as radiotracers for in vivo imaging of 5-HT1A receptors by Wilson, Alan A., Garcia, Armando, Li, Jin, Dasilva, Jean N., Houle, Sylvain

“…Two diastereoisomeric analogues of the potent 5‐HT1A antagonist W A Y 100635 have been synthesized and radiolabelled with 11C; namely trans‐ and…”
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