Search Results - "Dash, Rupesh"
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The Impact of m6A RNA Modification in Therapy Resistance of Cancer: Implication in Chemotherapy, Radiotherapy, and Immunotherapy
Published in Frontiers in oncology (25-02-2021)“…m6A RNA methylation, which serves as a critical regulator of transcript expression, has gathered tremendous scientific interest in recent years. From RNA…”
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2
Bcl-2 Antiapoptotic Family Proteins and Chemoresistance in Cancer
Published in Advances in cancer research (2018)“…Cancer is a daunting global problem confronting the world's population. The most frequent therapeutic approaches include surgery, chemotherapy, radiotherapy,…”
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3
Role of Excitatory Amino Acid Transporter-2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics
Published in Journal of cellular physiology (01-10-2011)“…Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory amino acid transporter (EAAT)‐2 is one of the major glutamate…”
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4
An integrated approach for identification of a panel of candidate genes arbitrated for invasion and metastasis in oral squamous cell carcinoma
Published in Scientific reports (18-03-2021)“…Oral squamous cell carcinoma (OSCC) is known for its aggressiveness associated with poor prognosis. The molecular mechanisms underlying the invasion and…”
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The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer
Published in Biomaterials (01-05-2011)“…Abstract Celecoxib has shown potential anticancer activity against most carcinomas, especially in patients with familial adenomatous polyposis and precancerous…”
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Natural protective glue protein, sericin bioengineered by silkworms: Potential for biomedical and biotechnological applications
Published in Progress in polymer science (01-10-2008)“…Silk proteins consist of a fibrous core protein, fibroin, and glue proteins called sericins, which envelop the fibroin fiber with successive sticky layers that…”
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Targeting the Bcl-2 family for cancer therapy
Published in Expert opinion on therapeutic targets (01-01-2013)“…Programmed cell death is well-orchestrated process regulated by multiple pro-apoptotic and anti-apoptotic genes, particularly those of the Bcl-2 gene family…”
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Identification of oral cancer related candidate genes by integrating protein-protein interactions, gene ontology, pathway analysis and immunohistochemistry
Published in Scientific reports (30-05-2017)“…In the recent years, bioinformatics methods have been reported with a high degree of success for candidate gene identification. In this milieu, we have used an…”
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RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression
Published in Cancer research (Chicago, Ill.) (15-01-2021)“…DZIP3/hRUL138 is a poorly characterized RNA-binding RING E3-ubiquitin ligase with functions in embryonic development. Here we demonstrate that DZIP3 is a…”
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MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma
Published in Cancer research (Chicago, Ill.) (15-01-2013)“…Melanoma differentiation-associated gene-9 (mda-9/syntenin) encodes an adapter scaffold protein whose expression correlates with and mediates melanoma…”
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Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity
Published in Proceedings of the National Academy of Sciences - PNAS (24-05-2011)“…Limited options are available for treating patients with advanced prostate cancer (PC). Melanoma differentiation associated gene-7/interleukin-24…”
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Correction: RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway
Published in British journal of cancer (08-06-2021)Get full text
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13
Antioxidant potential of silk protein sericin against hydrogen peroxide-induced oxidative stress in skin fibroblasts
Published in BMB reports (31-03-2008)“…The antioxidant potential of silk protein sericin from the non-mulberry tropical tasar silkworm Antheraea mylitta cocoon has been assessed and compared with…”
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Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India
Published in Frontiers in microbiology (30-06-2022)“…The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as a serious pandemic has altered the global socioeconomic dynamics. The wide…”
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CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3β axis
Published in JCI insight (22-02-2021)“…Rewiring tumor cells to undergo drug-induced apoptosis is a promising way to overcome chemoresistance. Therefore, identifying causative factors for…”
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DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG
Published in Apoptosis (London) (01-04-2020)“…Platinum based drugs alone or in combination with 5FU and docetaxel are common regimen chemotherapeutics for the treatment of advanced OSCC. Chemoresistance is…”
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Oncogene AEG-1 Promotes Glioma-Induced Neurodegeneration by Increasing Glutamate Excitotoxicity
Published in Cancer research (Chicago, Ill.) (15-10-2011)“…Aggressive tumor growth, diffuse tissue invasion, and neurodegeneration are hallmarks of malignant glioma. Although glutamate excitotoxicity is considered to…”
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Novel Mechanism of MDA-7/IL-24 Cancer-Specific Apoptosis through SARI Induction
Published in Cancer research (Chicago, Ill.) (15-01-2014)“…Subtraction hybridization combined with induction of cancer cell terminal differentiation in human melanoma cells identified melanoma…”
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Mcl-1 is an important therapeutic target for oral squamous cell carcinomas
Published in Oncotarget (30-06-2015)“…Oral and oropharyngeal cancers are the sixth most common cancers worldwide. Despite intensive investigation, oral squamous cell carcinomas (OSCC) represent a…”
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ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells
Published in Cancer biology & therapy (15-04-2010)“…Abnormalities in gene expression and signaling pathways downstream of the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor…”
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