Search Results - "Dash, Raju"
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Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System
Published in Frontiers in molecular neuroscience (02-07-2020)“…Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related disorders, including neurodegenerative diseases and ischemic…”
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Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants
Published in Scientific reports (27-02-2020)“…Recently, the critical roles played by genetic variants of TREM2 (Triggering Receptor Expressed on Myeloid cells 2) in Alzheimer’s disease have been…”
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Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances
Published in Marine drugs (01-07-2020)“…Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites…”
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The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
Published in Frontiers in pharmacology (10-10-2022)“…Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the risk of neurodegenerative diseases. Fisetin is a flavonoid that…”
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Unveiling the Potentiality of Shikonin Derivatives Inhibiting SARS-CoV-2 Main Protease by Molecular Dynamic Simulation Studies
Published in International journal of molecular sciences (01-02-2023)“…Shikonin, a phytochemical present in the roots of is well-known for its broad-spectrum activity against cancer, oxidative stress, inflammation, viruses, and…”
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Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety
Published in Nutrients (24-05-2021)“…Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly…”
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Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway
Published in Frontiers in pharmacology (07-05-2021)“…Bioactive plant derived compounds are important for a wide range of therapeutic applications, and some display promising anticancer properties. Further…”
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Brain modulation by the gut microbiota: From disease to therapy
Published in Journal of advanced research (01-11-2023)“…[Display omitted] •Gut microbiota (GM) and brain have a bidirectional relationship.•A healthy GM composition promotes brain growth and protection by…”
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Phytosterols: Targeting Neuroinflammation in Neurodegeneration
Published in Current pharmaceutical design (2021)“…Plant-derived sterols, phytosterols, are well known for their cholesterol-lowering activity in serum and their anti-inflammatory activities. Recently,…”
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Neuronal Differentiation and Outgrowth Effect of Thymol in Trachyspermum ammi Seed Extract via BDNF/TrkB Signaling Pathway in Prenatal Maternal Supplementation and Primary Hippocampal Culture
Published in International journal of molecular sciences (10-05-2023)“…Reviving the neuronal functions in neurodegenerative disorders requires the promotion of neurite outgrowth. Thymol, which is a principal component of seed…”
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Computational SNP Analysis and Molecular Simulation Revealed the Most Deleterious Missense Variants in the NBD1 Domain of Human ABCA1 Transporter
Published in International journal of molecular sciences (14-10-2020)“…The ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound exporter protein involved in regulating serum HDL level by exporting cholesterol and…”
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Revisiting potential druggable targets against SARS‐CoV‐2 and repurposing therapeutics under preclinical study and clinical trials: A comprehensive review
Published in Drug development research (01-12-2020)“…Coronavirus disease‐19 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is one of the most contagious diseases in human…”
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Differential Effects of the Processed and Unprocessed Garlic (Allium sativum L.) Ethanol Extracts on Neuritogenesis and Synaptogenesis in Rat Primary Hippocampal Neurons
Published in International journal of molecular sciences (01-09-2023)“…Garlic (Allium sativum L.) is an aromatic herb known for its culinary and medicinal uses for centuries. Both unprocessed (white) and processed (black) garlic…”
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Role of Actin-Binding Proteins in Skeletal Myogenesis
Published in Cells (Basel, Switzerland) (25-10-2023)“…Maintenance of skeletal muscle quantity and quality is essential to ensure various vital functions of the body. Muscle homeostasis is regulated by multiple…”
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Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review
Published in Heliyon (01-01-2022)“…Cancer has become a significant concern in the medical sector with increasing disease complexity. Although some available conventional treatments are still a…”
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N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance
Published in Cell death & disease (14-08-2020)“…Emerging evidence indicates that neurodegenerative diseases (NDs) result from a failure to clear toxic protein aggregates rather than from their generation. We…”
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Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function
Published in Scientific reports (07-06-2022)“…Single nucleotide variations in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) are associated with many neurodegenerative diseases, including…”
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Prospects of Marine Sterols against Pathobiology of Alzheimer's Disease: Pharmacological Insights and Technological Advances
Published in Marine drugs (20-03-2021)“…Alzheimer's disease (AD) is a degenerative brain disorder characterized by a progressive decline in memory and cognition, mostly affecting the elderly…”
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Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation
Published in Cells (Basel, Switzerland) (01-06-2024)“…Ubiquitin-specific protease 14 (USP14), one of the three major proteasome-associated deubiquitinating enzymes (DUBs), is known to be activated by the…”
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Unveiling the Structural Insights into the Selective Inhibition of Protein Kinase D1
Published in Current pharmaceutical design (01-01-2019)“…Although protein kinase D1 (PKD1) has been proved to be an efficient target for anticancer drug development, lack of structural details and substrate binding…”
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