Search Results - "Dasararaju, Gayathri"

Impact of aliphatic acyl and aromatic thioamide substituents on the anticancer activity of Ru(II)- p -cymene complexes with acylthiourea ligands- in vitro and in vivo studies by Swaminathan, Srividya, Haribabu, Jebiti, Mohamed Subarkhan, Mohamed Kasim, Gayathri, Dasararaju, Balakrishnan, Nithya, Bhuvanesh, Nattamai, Echeverria, Cesar, Karvembu, Ramasamy

“…Six different acylthiourea ligands (L1-L6) and their corresponding Ru(II)- -cymene complexes (P1-P6) were designed to explore the structure-activity…”
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Enhanced anticancer activity of half-sandwich Ru(II)-p-cymene complex bearing heterocyclic hydrazone ligand by Haribabu, Jebiti, Srividya, Swaminathan, Umapathi, Reddicherla, Gayathri, Dasararaju, Venkatesu, Pannuru, Bhuvanesh, Nattamai, Karvembu, Ramasamy

“…Ru(II)-p-cymene complex bearing indole hydrazone ligand was synthesized and characterized. The complex showed greater anticancer activity against A549 and HeLa…”
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Effective inhibition of insulin amyloid fibril aggregation by nickel(II) complexes containing heterocyclic thiosemicarbazones by Gomathi, Kannayiram, Haribabu, Jebiti, Saranya, Sivaraj, Gayathri, Dasararaju, Jeyalakshmi, Kumaramangalam, Sendilvelan, Subramanian, Echeverria, Cesar, Karvembu, Ramasamy

“…The sensitivity of protein molecular structures makes them susceptible to aggregation in conditions unfavorable for the maintenance of their native folds. The…”
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Synthesis, crystal structure, Hirshfeld analysis and in silico studies of 2-chloro-3-(p-tolyl)-3,4-dihydro-2H-benzo[e][1,3,2]oxazaphosphinine 2-sulfide by Kameswara Rao, Kodagala, Hari Hara Surendra Babu, Velakaturi, Syam Prasad, Gandavaram, Krishnaiah, Musali, Suresh Reddy, Cirandur, Gayathri, Dasararaju

“…Molecular structure of 2-chloro-3-(p-tolyl)-3,4-dihydro-2H-benzo[e][1,3,2]oxazaphosphinine 2-sulfide was determined using single crystal X-ray diffraction…”
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Crystal structures of the Schiff base derivatives ( E )- N ′-[(1 H -indol-3-yl)methylidene]isonicotinohydrazide ethanol monosolvate and ( E )- N -methyl-2-[1-(2-oxo-2 H -chromen-3-yl)ethylidene]hydrazinecarbothioamide by Saranya, Sivaraj, Haribabu, Jebiti, Bhuvanesh, Nattamai S. P., Karvembu, Ramasamy, Gayathri, Dasararaju

“…The crystal structures of two title Schiff base derivatives, C 15 H 12 N 4 O·C 2 H 6 O ( 1·EtOH ) and C 13 H 13 N 3 O 2 S ( 2 ), were determined at 110 and 100…”
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Crystal structure of 2-cyano-N-(furan-2-ylmeth-yl)acetamide by Subhadramma, Shivanna, Siddaraju, Budanur Papaiah, Naveen, Chandra, Saravanan, Janardhanan, Gayathri, Dasararaju

“…In the title compound, C8H8N2O2, the acetamide unit is inclined to the furan ring by 76.7 (1)°. In the crystal, mol-ecules are linked by N-H⋯O and C-H⋯O…”
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Crystal structure of 2-cyano-N-(furan-2-ylmeth-yl)-3-(3-nitro-phen-yl)propanamide by Subhadramma, Shivanna, Siddaraju, Budanur Papaiah, Chandra, Naveen, Saravanan, Janardhanan, Gayathri, Dasararaju

“…In the title compound, C15H11N3O4, the acetamide group is inclined to the furan ring by 66.5 (1)°. The dihedral angle between the furan ring and the benzene…”
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Crystal structure of 2-cyano- N -(furan-2-ylmethyl)acetamide. Corrigendum by Subhadramma, Shivanna, Siddaraju, Budanur Papaiah, Naveen, Chandra, Saravanan, Janardhanan, Gayathri, Dasararaju

“…The address of one of the authors in the paper by Subhadramma et al. [ Acta Cryst. (2015), E 71 , o455–o456] is corrected…”
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Synthesis of Palladium(II) Complexes via Michael Addition: Antiproliferative Effects through ROS-Mediated Mitochondrial Apoptosis and Docking with SARS-CoV‑2 by Haribabu, Jebiti, Srividya, Swaminathan, Mahendiran, Dharmasivam, Gayathri, Dasararaju, Venkatramu, Vemula, Bhuvanesh, Nattamai, Karvembu, Ramasamy

“…Metal complexes have numerous applications in the current era, particularly in the field of pharmaceutical chemistry and catalysis. A novel synthetic approach…”
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Discovery of potential TAAR1 agonist targeting neurological and psychiatric disorders: An in silico approach by Garisetti, Vasavi, Dhanabalan, Anantha Krishnan, Dasararaju, Gayathri

“…Trace amine-associated receptor 1 (TAAR1) is a G-protein-coupled receptor which is primarily expressed in the brain. It is activated by trace amines which play…”
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Orphan receptor GPR88 as a potential therapeutic target for CNS disorders - an in silico approach by Garisetti, Vasavi, Dhanabalan, Anantha Krishnan, Dasararaju, Gayathri

“…The G-protein-coupled receptors are a part of the largest and most physiologically relevant family of membrane proteins. One-third of the medications, now on…”
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Design and synthesis of heterocyclic azole based bioactive compounds: Molecular structures, quantum simulation, and mechanistic studies through docking as multi-target inhibitors of SARS-CoV-2 and cytotoxicity by Haribabu, Jebiti, Garisetti, Vasavi, Malekshah, Rahime Eshaghi, Srividya, Swaminathan, Gayathri, Dasararaju, Bhuvanesh, Nattamai, Mangalaraja, Ramalinga Viswanathan, Echeverria, Cesar, Karvembu, Ramasamy

“…•Synthesis and characterization of two heterocyclic azole compounds.•Theoretical studies were ascertained for azole compounds.•Azole compounds showed effective…”
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Synthesis, cytotoxicity and docking studies (with SARS-CoV-2) of water-soluble binuclear Ru-p-cymene complex holding indole thiosemicarbazone ligand by Haribabu, Jebiti, Balakrishnan, Nithya, Swaminathan, Srividya, Peter, Jerome, Gayathri, Dasararaju, Echeverria, Cesar, Bhuvanesh, Nattamai, Karvembu, Ramasamy

“…Piano-stool water-soluble binuclear organometallic Ru-p-cymene complex was synthesized and characterized. The complex exhibited superior activity than…”
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Anti-Cancer Compounds from Terrestrial and Marine Resources -In silico and Experimental Studies by Devadasan, Velmurugan, Raman, Pachiappan, Dasararaju, Gayathri

“…In both developing and developed countries, cancer is among the leading causes of millions of deaths. The incidence of cancer is increasing due to…”
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Synthesis, spectroscopic characterizations, single crystal X-ray analysis, DFT calculations, in vitro biological evaluation and in silico evaluation studies of thiosemicarbazones based 1,3,4-thiadiazoles by Palakkeezhillam, Vishnunarayanan Namboothiri Vadakkedathu, Haribabu, Jebiti, Manakkadan, Vipin, Rasin, Puthiyavalappil, Varughese, Roslin Elsa, Gayathri, Dasararaju, Bhuvanesh, Nattamai, Echeverria, Cesar, Sreekanth, Anandaram

“…•Two pyrene-based thiosemicarbazones and their cyclized thiadiazole compounds synthesized and characterized.•The molecular structure of both types was…”
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Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives by Mohd Siddique, Mohd Usman, Thakur, Abhishek, Shilkar, Deepak, Yasmin, Sabina, Halakova, Dominika, Kovacikova, Lucia, Prnova, Marta Soltesova, Stefek, Milan, Acevedo, Orlando, Dasararaju, Gayathri, Devadasan, Velmurugan, Mondal, Susanta Kumar, Jayaprakash, Venkatesan

“…In search of dually active PPAR-modulators/aldose reductase (ALR2) inhibitors, 16 benzylidene thiazolidinedione derivatives, previously reported as partial…”
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Synthesis, crystal structure, and in vitro and in silico molecular docking of novel acyl thiourea derivatives by Haribabu, Jebiti, Subhashree, Govindarajulu Rangabashyam, Saranya, Sivaraj, Gomathi, Kannayiram, Karvembu, Ramasamy, Gayathri, Dasararaju

“…A series of six biologically active acyl thiourea compounds has been synthesized and characterized by various spectroscopic techniques. Three dimensional…”
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Virtual screening, molecular docking and dynamics simulation studies to identify potential agonists of orphan receptor GPR78 targeting CNS disorders by Garisetti, Vasavi, Varughese, Roslin Elsa, Anandamurthy, Arthikasree, Haribabu, Jebiti, Allard Garrote, Claudio, Dasararaju, Gayathri

“…G protein-coupled receptors (GPCRs) are important targets in drug discovery because of their roles in physiological and pathological processes. Orphan GPCRs…”
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Multifaceted exploration of acylthiourea compounds: In vitro cytotoxicity, DFT calculations, molecular docking and dynamics simulation studies by Haribabu, Jebiti, Madhavan, Geetha, Swaminathan, Srividya, Panneerselvam, Murugesan, Moraga, Daniel, Dasararaju, Gayathri, Echeverria, Cesar, Arulraj, Arunachalam, Mangalaraja, Ramalinga Viswanathan, Kokkarachedu, Varaprasad, Santibanez, Juan F., Ramirez-Tagle, Rodrigo

“…This study reports the synthesis and analysis of biologically active acylthiourea compounds (1 and 2) with a cyclohexyl moiety. The compounds were…”
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Bis(acylthiourea) compounds as enzyme inhibitors: Synthesis, characterization, crystal structures and in silico molecular docking studies by Jerome, Peter, Haribabu, Jebiti, Dorairaj, Dorothy Priyanka, Azam, Mohammad, Madhavan, Geetha, Gayathri, Dasararaju, Ramirez-Tagle, Rodrigo, Bhuvanesh, Nattamai, Gallardo-Nelson, María José, Oh, Tae Hwan, Karvembu, Ramasamy

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