Search Results - "Das, Sonia G"

A Novel Class of Human ADAM8 Inhibitory Antibodies for Treatment of Triple-Negative Breast Cancer by Mineva, Nora D, Pianetti, Stefania, Das, Sonia G, Srinivasan, Srimathi, Billiald, Nicolas M, Sonenshein, Gail E

“…New targeted treatments are urgently needed to improve triple-negative breast cancer (TNBC) patient survival. Previously, we identified the cell surface…”
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A Facile Asymmetric Synthesis of Either Enantiomer of 2-Substituted Pyrrolidines by Rajender Reddy, Leleti, Das, Sonia G, Liu, Yugang, Prashad, Mahavir

“…A new and general method for asymmetric synthesis of either enantiomer of 2-substituted pyrrolidines from a single starting material is described. Reductive…”
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Overexpression of Mcl-1 confers multidrug resistance, whereas topoisomerase IIβ downregulation introduces mitoxantrone-specific drug resistance in acute myeloid leukemia by Hermanson, David L, Das, Sonia G, Li, Yunfang, Xing, Chengguo

“…Drug resistance is a serious challenge in cancer treatment and can be acquired through multiple mechanisms. These molecular changes may introduce varied…”
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miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells by Das, Sonia G, Romagnoli, Mathilde, Mineva, Nora D, Barillé-Nion, Sophie, Jézéquel, Pascal, Campone, Mario, Sonenshein, Gail E

“…ADAM8 (a disintegrin and metalloproteinase 8) protein promotes the invasive and metastatic phenotype of triple-negative breast cancer (TNBC) cells. High ADAM8…”
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Putative Identification of New Phragmaline-Type Limonoids from the Leaves of Swietenia macrophylla King: A Case Study Using Mass Spectrometry-Based Molecular Networking by Reis, José, Gomes, Paulo, Sá, Paulo, Pamplona, Sônia, Silva, Consuelo, da Silva, Maria, Bishayee, Anupam, da Silva, Milton

“…Swietenia macrophylla King is a plant commonly known as Brazilian mahogany. The wood from its stem is highly prized for its exceptional quality, while its…”
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Structure–Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and Its Analogues by Das, Sonia G, Srinivasan, Balasubramanian, Hermanson, David L, Bleeker, Nicholas P, Doshi, Jignesh M, Tang, Ruoping, Beck, William T, Xing, Chengguo

“…Multidrug resistance (MDR) in cancer is a phenomenon in which administration of a single chemotherapeutic agent causes cross-resistance of cancer cells to a…”
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Structure−Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4H-chromene-3-carboxylate (sHA 14-1) and Its Analogues by Das, Sonia G, Doshi, Jignesh M, Tian, Defeng, Addo, Sadiya N, Srinivasan, Balasubramanian, Hermanson, David L, Xing, Chengguo

“…Rapid development of multiple drug resistance against current therapies is a major barrier in the treatment of cancer. Therefore, anticancer agents that can…”
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Untargeted-based metabolomics analysis and in vitro/in silico antiviral activity of extracts from Phyllanthus brasiliensis (Aubl.) Poir by Carvalho, Alice Rhelly V, Reis, José Diogo E, Gomes, Paulo Wender P, Ferraz, Ariane Coelho, Mardegan, Horrana A, Menegatto, Marília Bueno da Silva, Souza Lima, Rafaela Lameira, de Sarges, Maria Rosilda V, Pamplona, Sônia das G S R, Jeunon Gontijo, Karen Sartori, de Magalhães, José Carlos, da Silva, Milton N, Magalhães, Cintia Lopes de Brito, Silva, Consuelo Yumiko Yoshioka E

“…This study describes the molecular profile and the potential antiviral activity of extracts from Phyllanthus brasiliensis, a plant widely found in the…”
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sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell by Tian, Defeng, Das, Sonia G, Doshi, Jignesh M, Peng, Jun, Lin, Jialing, Xing, Chengguo

“…Abstract HA 14-1, a small-molecule antagonist against anti-apoptotic Bcl-2 proteins, was demonstrated to induce selective cytotoxicity toward malignant cells…”
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Ethyl 2‑Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)‑4H‑chromene-3-carboxylate (CXL017): A Novel Scaffold That Resensitizes Multidrug Resistant Leukemia Cells to Chemotherapy by Das, Sonia G, Hermanson, David L, Bleeker, Nicholas, Lowman, Xazmin, Li, Yunfang, Kelekar, Ameeta, Xing, Chengguo

“…Multidrug resistance (MDR) is a major hurdle in the treatment of cancer, and there is a pressing need for new therapies. We have recently developed ethyl…”
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Abstract 23: Antibody targeting of ADAM8 for treatment of triple-negative breast cancer by Das, Sonia G., Pianetti, Stefania, Sonenshein, Gail E., Mineva, Nora D.

“…Abstract Triple-Negative Breast Cancer (TNBC) accounts for 25% of breast cancer deaths. Current therapeutic options are restricted to chemotherapy (CT) and…”
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Abstract 6639: SRF617, a potent enzymatic inhibitor of CD39, demonstrates single-agent activity and cooperates with various cancer therapies in both solid tumor and hematologic malignancies by Das, Sonia G., Dulak, Austin, Tan, Gege, Johnson, Marc, Zaidi, Tauqeer H., Warren, Michael C., Koseoglu, Secil, Devereaux, Erik, Peluso, Marisa O., Paterson, Alison M., Lee, Benjamin H., Palombella, Vito J., Holland, Pamela M., Lake, Andrew C.

“…Abstract CD39 (ENTPD1) is a key enzyme responsible for the degradation of extracellular adenosine triphosphate (ATP) and is upregulated in the tumor…”
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Abstract 1137: ADAM8 drives aggressive phenotype of triple-negative inflammatory breast cancer & constitutes a novel therapeutic target by Romagnoli, Mathilde, Pianetti, Stefania, Das, Sonia G., Loussouarn, Delphine, Gourmelon, Carole, Campone, Mario, Barillé-Nion, Sophie, Nguyen, Giang T., Srinivasan, Srimathi, Sonenshein, Gail E., Mineva, Nora D.

“…Abstract Inflammatory Breast Cancer (IBC) is a rare, highly aggressive form of cancer that is frequently locally advanced or metastasized at the time of…”
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Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4 H -chromene-3-carboxylate (CXL017): A Novel Scaffold That Resensitizes Multidrug Resistant Leukemia Cells to Chemotherapy by Das, Sonia G., Hermanson, David L., Bleeker, Nicholas, Lowman, Xazmin, Li, Yunfang, Kelekar, Ameeta, Xing, Chengguo

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Characterization of a tetrameric proanthocyanidin in Stryphnodendron pulcherrimum and an overview on potential health benefits of condensed tannins via interaction with gut microbiota by Gomes, Paulo Wender P., Gomes, Emilli Roberta S., Carvalho, Alice R.V., Mannochio-Russo, Helena, Leão, Tiago F., Reis, José Diogo E., de Sarges, Maria Rosilda V., Mardegan, Horrana A., Pamplona, Sônia das G.S.R., Y. e Silva, Consuelo Yumiko, da Silva, Milton N.

“…[Display omitted] •A tetrameric condensed tannin of (epi)catechin-(epi)gallocatechin was described for the first time in the barks from Stryphnodendron…”
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Abstract B166: MicroRNAs downstream of ADAM8 as therapeutic targets and non-invasive biomarkers for triple-negative breast cancer by Das, Sonia G., Romagnoli, Mathilde, Mineva, Nora D., Sonenshein, Gail E.

“…Abstract Triple-negative breast cancer (TNBC) represents ∼20% of breast cancers, is highly aggressive and lacks targeted therapies due to the absence of…”
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Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) – a novel scaffold that re-sensitizes multidrug resistant leukemia cells to chemotherapy by Das, Sonia G., Hermanson, David L., Bleeker, Nicholas, Lowman, Xazmin, Li, Yunfang, Kelekar, Ameeta, Xing, Chengguo

“…Multidrug resistance (MDR) is a major hurdle in the treatment of cancer and there is a pressing need for new therapies. We have recently developed ethyl…”
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Structure–Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4 H -chromene-3-carboxylate (CXL017) and Its Analogues by Das, Sonia G., Srinivasan, Balasubramanian, Hermanson, David L., Bleeker, Nicholas P., Doshi, Jignesh M., Tang, Ruoping, Beck, William T., Xing, Chengguo

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Structure−Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4 H -chromene-3-carboxylate (sHA 14-1) and Its Analogues by Das, Sonia G., Doshi, Jignesh M., Tian, Defeng, Addo, Sadiya N., Srinivasan, Balasubramanian, Hermanson, David L., Xing, Chengguo

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Putative Identification of New Phragmaline-Type Limonoids from the Leaves of ISwietenia macrophylla/I King: A Case Study Using Mass Spectrometry-Based Molecular Networking by Reis, José Diogo E, Gomes, Paulo Wender P, Sá, Paulo R. da C, Pamplona, Sônia das G. S. R, Silva, Consuelo Yumiko Y. e, da Silva, Maria Fátima das G. F, Bishayee, Anupam, da Silva, Milton Nascimento

“…Swietenia macrophylla King is a plant commonly known as Brazilian mahogany. The wood from its stem is highly prized for its exceptional quality, while its…”
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