Search Results - "Das, Shipra"

Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer by Das, Shipra, Krainer, Adrian R

“…Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splicing regulators. Since its discovery over two decades ago,…”
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Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy by Das, Shipra, Valton, Julien, Duchateau, Philippe, Poirot, Laurent

“…Adoptive cell therapy based on chimeric antigen receptor (CAR)-engineered T-cells has proven to be lifesaving for many cancer patients. However, its…”
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BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis by Das, Shipra, Bar-Sagi, Dafna

“…The immune microenvironment of pancreatic ductal adenocarcinoma (PDA) is comprised of a heterogeneous population of cells that are critical for disease…”
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IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia by Pylayeva-Gupta, Yuliya, Das, Shipra, Handler, Jesse S, Hajdu, Cristina H, Coffre, Maryaline, Koralov, Sergei B, Bar-Sagi, Dafna

“…A salient feature of pancreatic ductal adenocarcinoma (PDAC) is an abundant fibroinflammatory response characterized by the recruitment of immune and…”
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The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation by Anczuków, Olga, Rosenberg, Avi Z, Akerman, Martin, Das, Shipra, Zhan, Lixing, Karni, Rotem, Muthuswamy, Senthil K, Krainer, Adrian R

“…The splicing factor SRSF1 is an oncoprotein that is upregulated in human tumors, including breast cancer tumors. New in vitro and in vivo analyses reveal…”
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Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing by Jo, Sumin, Das, Shipra, Williams, Alan, Chretien, Anne-Sophie, Pagliardini, Thomas, Le Roy, Aude, Fernandez, Jorge Postigo, Le Clerre, Diane, Jahangiri, Billal, Chion-Sotinel, Isabelle, Rozlan, Sandra, Dessez, Emilie, Gouble, Agnes, Dusséaux, Mathilde, Galetto, Roman, Duclert, Aymeric, Marcenaro, Emanuela, Devillier, Raynier, Olive, Daniel, Duchateau, Philippe, Poirot, Laurent, Valton, Julien

“…Universal CAR T-cell therapies are poised to revolutionize cancer treatment and to improve patient outcomes. However, realizing these advantages in an…”
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Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC by Das, Shipra, Anczuków, Olga, Akerman, Martin, Krainer, Adrian R.

“…The SR protein splicing factor SRSF1 is a potent proto-oncogene that is frequently upregulated in cancer. Here, we show that SRSF1 is a direct target of the…”
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Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis by Park, SungHee, Brugiolo, Mattia, Akerman, Martin, Das, Shipra, Urbanski, Laura, Geier, Adam, Kesarwani, Anil K., Fan, Martin, Leclair, Nathan, Lin, Kuan-Ting, Hu, Leo, Hua, Ian, George, Joshy, Muthuswamy, Senthil K., Krainer, Adrian R., Anczuków, Olga

“…Misregulation of alternative splicing is a hallmark of human tumors, yet to what extent and how it contributes to malignancy are only beginning to be…”
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Differential connectivity of splicing activators and repressors to the human spliceosome by Akerman, Martin, Fregoso, Oliver I, Das, Shipra, Ruse, Cristian, Jensen, Mads A, Pappin, Darryl J, Zhang, Michael Q, Krainer, Adrian R

“…During spliceosome assembly, protein-protein interactions (PPI) are sequentially formed and disrupted to accommodate the spatial requirements of pre-mRNA…”
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Tumor Cell-Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer by Das, Shipra, Shapiro, Beny, Vucic, Emily A, Vogt, Sandra, Bar-Sagi, Dafna

“…Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes…”
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Kras and Tumor Immunity: Friend or Foe? by Cullis, Jane, Das, Shipra, Bar-Sagi, Dafna

“…With the recent breakthroughs in immunotherapy as curative treatments in certain tumor types, there has been renewed interest in the relationship between…”
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BTK signaling drives CD1d.sup.hiCD5.sup.+ regulatory B-cell differentiation to promote pancreatic carcinogenesis by Das, Shipra, Bar-Sagi, Dafna

“…The immune microenvironment of pancreatic ductal adenocarcinoma (PDA) is comprised of a heterogeneous population of cells that are critical for disease…”
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Screening, production, optimization and characterization of cyanobacterial polysaccharide by Singh, Surendra, Das, Shipra

“…Biotechnological applications of algal polysaccharide as emulsifiers, thickeners and laxatives have led to the screening and selection of certain diazotrophic…”
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Chemistry and Physics of Triple Perovskite Oxides: A Topical Review by De, Santanu, Kurian, Mahima M., Solaiappan, Leelashree, Kumar, Arun, Das, Shipra, Samanta, Sourav, Arafath, Yasar K., Nagappan Nair, Santhosh P.

“…Triple perovskites have garnered research interest in recent years because of their diverse physical properties. This review article delves into the…”
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TUMOR CELL-DERIVED IL-1β PROMOTES DESMOPLASIA AND IMMUNE SUPPRESSION IN PANCREATIC CANCER by Das, Shipra, Shapiro, Beny, Vucic, Emily A., Vogt, Sandra, Bar-Sagi, Dafna

“…Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes…”
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BTK signaling drives CD1d hi CD5 + regulatory B-cell differentiation to promote pancreatic carcinogenesis by Das, Shipra, Bar-Sagi, Dafna

“…The immune microenvironment of pancreatic ductal adenocarcinoma (PDA) is comprised of a heterogeneous population of cells that are critical for disease…”
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Splicing-Factor Oncoprotein SRSF1 Stabilizes p53 via RPL5 and Induces Cellular Senescence by Fregoso, Oliver I., Das, Shipra, Akerman, Martin, Krainer, Adrian R.

“…Splicing and translation are highly regulated steps of gene expression. Altered expression of proteins involved in these processes can be deleterious…”
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Abstract A50: Nonredundant functions of splicing factors in breast-cancer initiation and metastasis by Anczuków, Olga, Das, Shipra, Lin, Kuan-Ting, Wu, Jie, Akerman, Martin, Muthuswamy, Senthil K., Krainer, Adrian R.

“…Abstract Alternative splicing is a key control point in gene expression, whose misregulation contributes to cancer malignancy. Although certain splicing…”
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A new path to oncogene-induced senescence: At the crossroads of splicing and translation by Das, Shipra, Fregoso, Oliver I., Krainer, Adrian R.

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Abstract B53: Differential functions of splicing factors in breast-cancer initiation and metastasis by Anczukow, Olga, Lin, Kuan-Ting, Akerman, Martin, Das, Shipra, Muthuswamy, Senthil K., Krainer, Adrian

“…Abstract Cancer cells often display aberrant profiles of alternative splicing, leading to the production of isoforms that can stimulate cell proliferation and…”
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