Search Results - "Das, Debananda"

Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication by Maeda, Kenji, Das, Debananda, Kobayakawa, Takuya, Tamamura, Hirokazu, Takeuchi, Hiroaki

“…The history of the human immunodeficiency virus (HIV)/AIDS therapy, which spans over 30 years, is one of the most dramatic stories of science and medicine…”
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A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication by Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Hayashi, Hironori, Allu, Srinivasa Rao, Raghavaiah, Jakka, Bulut, Haydar, Das, Debananda, Anson, Brandon J., Lendy, Emma K., Takamatsu, Yuki, Takamune, Nobutoki, Kishimoto, Naoki, Murayama, Kazutaka, Hasegawa, Kazuya, Li, Mi, Davis, David A., Kodama, Eiichi N., Yarchoan, Robert, Wlodawer, Alexander, Misumi, Shogo, Mesecar, Andrew D., Ghosh, Arun K., Mitsuya, Hiroaki

“…Except remdesivir, no specific antivirals for SARS-CoV-2 infection are currently available. Here, we characterize two small-molecule-compounds, named GRL-1720…”
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GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection by Hattori, Shin-Ichiro, Higshi-Kuwata, Nobuyo, Raghavaiah, Jakka, Das, Debananda, Bulut, Haydar, Davis, David A, Takamatsu, Yuki, Matsuda, Kouki, Takamune, Nobutoki, Kishimoto, Naoki, Okamura, Tadashi, Misumi, Shogo, Yarchoan, Robert, Maeda, Kenji, Ghosh, Arun K, Mitsuya, Hiroaki

“…We assessed various newly generated compounds that target the main protease (M ) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and various…”
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Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity by Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki

“…HIV-1 protease inhibitors (PIs), such as darunavir (DRV), are the key component of antiretroviral therapy. However, HIV-1 often acquires resistance to PIs…”
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Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance by Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K, Mitsuya, Hiroaki

“…Darunavir (DRV) has bimodal activity against HIV-1 protease, enzymatic inhibition and protease dimerization inhibition, and has an extremely high genetic…”
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Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV by Higashi-Kuwata, Nobuyo, Hayashi, Sanae, Kumamoto, Hiroki, Ogata-Aoki, Hiromi, Das, Debananda, Venzon, David, Hattori, Shin-ichiro, Bulut, Haydar, Hashimoto, Mai, Otagiri, Masaki, Takamune, Nobutoki, Kishimoto, Naoki, Davis, David A., Misumi, Shogo, Kakuni, Masakazu, Tanaka, Yasuhito, Mitsuya, Hiroaki

“…While certain nucleos(t)ide reverse transcriptase inhibitors (NRTIs) are efficacious in treating HBV infection, their effects are yet to be optimized and the…”
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Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir by Hayashi, Hironori, Takamune, Nobutoki, Nirasawa, Takashi, Aoki, Manabu, Morishita, Yoshihiko, Das, Debananda, Koh, Yasuhiro, Ghosh, Arun K., Misumi, Shogo, Mitsuya, Hiroaki

“…Dimerization of HIV-1 protease (PR) subunits is an essential process for PR’s acquisition of proteolytic activity, which plays a critical role in the…”
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Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s by Nakata, Hirotomo, Maeda, Kenji, Das, Debananda, Chang, Simon B., Matsuda, Kouki, Rao, Kalapala Venkateswara, Harada, Shigeyoshi, Yoshimura, Kazuhisa, Ghosh, Arun K., Mitsuya, Hiroaki

“…CCR5 is a member of the G-protein coupled receptor family that serves as an essential co-receptor for cellular entry of R5-tropic HIV-1, and is a validated…”
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Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2 by Higashi-Kuwata, Nobuyo, Tsuji, Kohei, Hayashi, Hironori, Bulut, Haydar, Kiso, Maki, Imai, Masaki, Ogata-Aoki, Hiromi, Ishii, Takahiro, Kobayakawa, Takuya, Nakano, Kenta, Takamune, Nobutoki, Kishimoto, Naoki, Hattori, Shin-ichiro, Das, Debananda, Uemura, Yukari, Shimizu, Yosuke, Aoki, Manabu, Hasegawa, Kazuya, Suzuki, Satoshi, Nishiyama, Akie, Saruwatari, Junji, Shimizu, Yukiko, Sukenaga, Yoshikazu, Takamatsu, Yuki, Tsuchiya, Kiyoto, Maeda, Kenji, Yoshimura, Kazuhisa, Iida, Shun, Ozono, Seiya, Suzuki, Tadaki, Okamura, Tadashi, Misumi, Shogo, Kawaoka, Yoshihiro, Tamamura, Hirokazu, Mitsuya, Hiroaki

“…COVID-19 caused by SARS-CoV-2 has continually been serious threat to public health worldwide. While a few anti-SARS-CoV-2 therapeutics are currently available,…”
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4′‐modified nucleoside analogs: Potent inhibitors active against entecavir‐resistant hepatitis B virus by Takamatsu, Yuki, Tanaka, Yasuhito, Kohgo, Satoru, Murakami, Shuko, Singh, Kamalendra, Das, Debananda, Venzon, David J., Amano, Masayuki, Higashi‐Kuwata, Nobuyo, Aoki, Manabu, Delino, Nicole S., Hayashi, Sanae, Takahashi, Satoru, Sukenaga, Yoshikazu, Haraguchi, Kazuhiro, Sarafianos, Stefan G., Maeda, Kenji, Mitsuya, Hiroaki

“…Certain nucleoside/nucleotide reverse transcriptase (RT) inhibitors (NRTIs) are effective against human immunodeficiency virus type 1 (HIV‐1) and hepatitis B…”
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In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors by KOH, Yasuhiro, AMANO, Masayuki, TOWATA, Tomomi, DANISH, Matthew, LESHCHENKO-YASHCHUK, Sofiya, DAS, Debananda, NAKAYAMA, Maki, TOJO, Yasushi, GHOSH, Arun K, MITSUYA, Hiroaki

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GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants by Delino, Nicole S, Aoki, Manabu, Hayashi, Hironori, Hattori, Shin-Ichiro, Chang, Simon B, Takamatsu, Yuki, Martyr, Cuthbert D, Das, Debananda, Ghosh, Arun K, Mitsuya, Hiroaki

“…We identified four novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs), GRL-078, -079, -077, and -058, containing an…”
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A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency by Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-Ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki

“…Antiretroviral therapy for HIV-1 infection/AIDS has significantly extended the life expectancy of HIV-1-infected individuals and reduced HIV-1 transmission at…”
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Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl Small Molecule Inhibitors of Protease Dimerization by Koh, Yasuhiro, Matsumi, Shintaro, Das, Debananda, Amano, Masayuki, Davis, David A., Li, Jianfeng, Leschenko, Sofiya, Baldridge, Abigail, Shioda, Tatsuo, Yarchoan, Robert, Ghosh, Arun K., Mitsuya, Hiroaki

“…Dimerization of HIV-1 protease subunits is essential for its proteolytic activity, which plays a critical role in HIV-1 replication. Hence, the inhibition of…”
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C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir by Aoki, Manabu, Hayashi, Hironori, Yedidi, Ravikiran S, Martyr, Cuthbert D, Takamatsu, Yuki, Aoki-Ogata, Hiromi, Nakamura, Teruya, Nakata, Hirotomo, Das, Debananda, Yamagata, Yuriko, Ghosh, Arun K, Mitsuya, Hiroaki

“…We identified three nonpeptidic HIV-1 protease inhibitors (PIs), GRL-015, -085, and -097, containing tetrahydropyrano-tetrahydrofuran (Tp-THF) with a C-5…”
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Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV-1 by AOKI, Manabu, DANISH, Matthew L, AOKI-OGATA, Hiromi, AMANO, Masayuki, IDE, Kazuhiko, DAS, Debananda, KOH, Yasuhiro, MITSUYA, Hiroaki

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Potent and biostable inhibitors of the main protease of SARS-CoV-2 by Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Higashi-Kuwata, Nobuyo, Azuma, Chika, Nakayama, Miyuki, Onishi, Takato, Nakano, Hiroki, Wada, Naoya, Hori, Miki, Shinohara, Kouki, Miura, Yutaro, Kawada, Takuma, Hayashi, Hironori, Hattori, Shin-ichiro, Bulut, Haydar, Das, Debananda, Takamune, Nobutoki, Kishimoto, Naoki, Saruwatari, Junji, Okamura, Tadashi, Nakano, Kenta, Misumi, Shogo, Mitsuya, Hiroaki, Tamamura, Hirokazu

“…Potent and biostable inhibitors of the main protease (Mpro) of SARS-CoV-2 were designed and synthesized based on an active hit compound 5h (2). Our strategy…”
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Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1 by KOH, Yasuhiro, AOKI, Manabu, DANISH, Matthew L, AOKI-OGATA, Hiromi, AMANO, Masayuki, DAS, Debananda, SHAFER, Robert W, GHOSH, Arun K, MITSUYA, Hiroaki

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A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance by Aoki, Manabu, Chang, Simon B., Das, Debananda, Martyr, Cuthbert, Delino, Nicole S., Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki

“…We designed, synthesized, and identified two novel nonpeptidic HIV-1 protease inhibitors (PIs), GRL-037 and GRL-044, containing…”
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GRL-04810 and GRL-05010, Difluoride-Containing Nonpeptidic HIV-1 Protease Inhibitors (PIs) That Inhibit the Replication of Multi-PI-Resistant HIV-1 In Vitro and Possess Favorable Lipophilicity That May Allow Blood-Brain Barrier Penetration by SALCEDO GOMEZ, Pedro Miguel, AMANO, Masayuki, YASHCHUK, Sofiya, MIZUNO, Akira, DAS, Debananda, GHOSH, Arun K, MITSUYA, Hiroaki

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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