Search Results - "Darzy, Ken"

Radiation-induced hypopituitarism after cancer therapy: who, how and when to test by Darzy, Ken H

“…Abnormalities in hypothalamic–pituitary axis function frequently occur in cancer survivors following prophylactic or therapeutic cranial irradiation. Growth…”
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Radiation-induced hypopituitarism by Darzy, Ken H.

“…Progressive and irreversible neuro-endocrine dysfunction following radiation-induced damage to the hypothalamic-pituitary (h-p) axis is the most common…”
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Modified-Release Hydrocortisone to Provide Circadian Cortisol Profiles by Debono, Miguel, Ghobadi, Cyrus, Rostami-Hodjegan, Amin, Huatan, Hiep, Campbell, Michael J., Newell-Price, John, Darzy, Ken, Merke, Deborah P., Arlt, Wiebke, Ross, Richard J.

“…Context: Cortisol has a distinct circadian rhythm regulated by the brain’s central pacemaker. Loss of this rhythm is associated with metabolic abnormalities,…”
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Hypopituitarism following radiotherapy by Darzy, Ken H, Shalet, Stephen M

“…Deficiencies in anterior pituitary hormones secretion ranging from subtle to complete occur following radiation damage to the hypothalamic-pituitary (h-p)…”
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1105-P: The Effect of Canagliflozin on Alanine Aminotransferase (ALT) Levels: Data from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit Programme by CRABTREE, THOMAS S.J., PHILLIPS, SUZANNE M., EVANS, ALISON, SENNIK, DEVESH K., ROHILLA, ANURITA, BICKERTON, ALEX, DARZY, KEN H., WINOCOUR, PETER, CULL, MELISSA L., STRZELECKA, ANNA, RAGHAVAN, RAJEEV P., GALLEN, IAN W., YADAGIRI, MAHENDER, RYDER, ROBERT E.

“…Background: Nonalcoholic fatty liver disease (NAFLD) is common amongst those with type 2 diabetes (T2DM). Alanine aminotransferase (ALT) is known to correlate…”
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1209-P: Relationship between Canagliflozin Treatment Response and Duration of Diabetes: The Association of British Clinical Diabetologists (ABCD) Nationwide Canagliflozin Audit by RYDER, ROBERT E.J., PHILLIPS, SUZANNE M., EVANS, ALISON, SENNIK, DEVESH K., ROHILLA, ANURITA, BICKERTON, ALEX, THONG, KEN, YADAGIRI, MAHENDER, CULL, MELISSA L., WYRES, MELANIE C., WINOCOUR, PETER, DARZY, KEN H., STRZELECKA, ANNA, GOHIL, SHAILESH G., GALLAGHER, ALISON, GALLEN, IAN W.

“…In the ABCD nationwide liraglutide audit the impact of liraglutide on HbA1c was found to lessen with increasing duration of diabetes (abstract 1038-P, ADA…”
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Circadian secretion pattern of copeptin, the C-terminal vasopressin precursor fragment by Darzy, Ken H, Dixit, Kashinath C, Shalet, Stephen M, Morgenthaler, Nils G, Brabant, Georg

“…Interestingly, the expected large increase in cortisol during the second half of the night in these individuals [see (4 )] is not related to copeptin. Because…”
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Cranial Irradiation and Growth Hormone Neurosecretory Dysfunction: A Critical Appraisal by Darzy, Ken H., Pezzoli, Suzan S., Thorner, Michael O., Shalet, Stephen M.

“…Context: It has been suggested that radiation-induced GH neurosecretory dysfunction exists in children; however, the pathophysiology is poorly understood, and…”
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Circadian and Stimulated Thyrotropin Secretion in Cranially Irradiated Adult Cancer Survivors by Darzy, Ken H., Shalet, Stephen M.

“…Context: It has been claimed that with the use of the TRH test and knowledge of the nocturnal TSH surge, the diagnosis of so-called hidden central…”
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Cranially irradiated adult cancer survivors may have normal spontaneous GH secretion in the presence of discordant peak GH responses to stimulation tests (compensated GH deficiency) by Darzy, Ken H., Thorner, Michael O., Shalet, Stephen M.

“…Summary Context  We have previously demonstrated that spontaneous (physiological) GH secretion was entirely normal in cranially irradiated patients who had…”
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Hypopituitarism following Radiotherapy Revisited by Darzy, Ken H, Shalet, Stephen M

“…Neuroendocrine disturbances in anterior pituitary hormone secretion are common following radiation damage to the hypothalamic-pituitary (H-P) axis, the…”
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Hypopituitarism as a consequence of brain tumours and radiotherapy by Darzy, Ken H, Shalet, Stephen M

“…Radiation-induced damage to the hypothalamic-pituitary (h-p) axis is associated with a wide spectrum of subtle and frank abnormalities in anterior pituitary…”
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Absence of Adrenocorticotropin (ACTH) Neurosecretory Dysfunction but Increased Cortisol Concentrations and Production Rates in ACTH-Replete Adult Cancer Survivors after Cranial Irradiation for Nonpituitary Brain Tumors by Darzy, Ken H., Shalet, Stephen M.

“…Context: For the first time, physiological cortisol secretion has been studied in ACTH-replete adult cancer survivors to explore any discrepancy between…”
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The Dynamics of Growth Hormone (GH) Secretion in Adult Cancer Survivors with Severe GH Deficiency Acquired after Brain Irradiation in Childhood for Nonpituitary Brain Tumors: Evidence for Preserved Pulsatility and Diurnal Variation with Increased Secretory Disorderliness by Darzy, Ken H., Pezzoli, Suzan S., Thorner, Michael O., Shalet, Stephen M.

“…Dynamics of GH secretion in patients with GH deficiency due to radiation damage of the hypothalamic-pituitary (h-p) axis acquired in childhood has rarely been…”
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Pathophysiology of radiation-induced growth hormone deficiency: Efficacy and safety of GH replacement by Darzy, Ken H., Shalet, Stephen M.

“…Radiation-induced growth hormone deficiency (GHD) is primarily due to hypothalamic damage. GH secretion by the pituitary may be affected either secondary to…”
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The Impact of Short-Term Fasting on the Dynamics of 24-Hour Growth Hormone (GH) Secretion in Patients with Severe Radiation-Induced GH Deficiency by Darzy, Ken H., Murray, Robert D., Gleeson, Helena K., Pezzoli, Suzan S., Thorner, Michael O., Shalet, Stephen M.

“…Context: In patients with severe radiation-induced GH deficiency, we previously demonstrated that pulsatile GH secretion and diurnal rhythm are maintained in…”
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Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers by Hernández-Ramírez, Laura C, Gabrovska, Plamena, Dénes, Judit, Stals, Karen, Trivellin, Giampaolo, Tilley, Daniel, Ferraù, Francesco, Evanson, Jane, Ellard, Sian, Grossman, Ashley B, Roncaroli, Federico, Gadelha, Mônica R, Korbonits, Márta

“…Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease…”
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Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype-phenotype correlations, codon bias and dominant-negative effects by Hannan, Fadil M, Howles, Sarah A, Rogers, Angela, Cranston, Treena, Gorvin, Caroline M, Babinsky, Valerie N, Reed, Anita A, Thakker, Clare E, Bockenhauer, Detlef, Brown, Rosalind S, Connell, John M, Cook, Jacqueline, Darzy, Ken, Ehtisham, Sarah, Graham, Una, Hulse, Tony, Hunter, Steven J, Izatt, Louise, Kumar, Dhavendra, McKenna, Malachi J, McKnight, John A, Morrison, Patrick J, Mughal, M Zulf, O'Halloran, Domhnall, Pearce, Simon H, Porteous, Mary E, Rahman, Mushtaqur, Richardson, Tristan, Robinson, Robert, Scheers, Isabelle, Siddique, Haroon, Van't Hoff, William G, Wang, Timothy, Whyte, Michael P, Nesbit, M Andrew, Thakker, Rajesh V

“…The adaptor protein-2 sigma subunit (AP2σ2) is pivotal for clathrin-mediated endocytosis of plasma membrane constituents such as the calcium-sensing receptor…”
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Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families by Igreja, Susana, Chahal, Harvinder S., King, Peter, Bolger, Graeme B., Srirangalingam, Umasuthan, Guasti, Leonardo, Chapple, J. Paul, Trivellin, Giampaolo, Gueorguiev, Maria, Guegan, Katie, Stals, Karen, Khoo, Bernard, Kumar, Ajith V., Ellard, Sian, Grossman, Ashley B., Korbonits, Márta

“…Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable genetic background and incomplete penetrance. Germline mutations of…”
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A seven-day diabetes service for inpatients and the emergency department in an acute hospital setting - the East and North Herts Diabetes Outreach Team (DOT) by Solomon, Andrew, George, Stella, Al-Sabbagh, Samer, Joharatnam, Jalini, Stanisstreet, Debbie, Currie, Anne, Hardy, Dawn, Jones, Carolyn, Abraham, Manjumol, Barker, Lynn, Summerhayes, Bev, Ford, Margaret, Chapman, Linda, O'Donnell, Laura, Kaplan, Felicity, Darzy, Ken, Zalin, Ben, Winocour, Peter

“…There is evidence that all hospital-based care needs to improve across 7 days. Inpatients with diabetes require better specialist attention and improved…”
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