Search Results - "Daryl L. Fernandes"

GlycoStore: a database of retention properties for glycan analysis by Zhao, Sophie, Walsh, Ian, Abrahams, Jodie L, Royle, Louise, Nguyen-Khuong, Terry, Spencer, Daniel, Fernandes, Daryl L, Packer, Nicolle H, Rudd, Pauline M, Campbell, Matthew P

“…Abstract Summary GlycoStore is a curated chromatographic, electrophoretic and mass-spectrometry composition database of N-, O-, glycosphingolipid (GSL) glycans…”
Get full text

High-throughput Serum N-Glycomics: Method Comparison and Application to Study Rheumatoid Arthritis and Pregnancy-associated Changes[S] by Reiding, Karli R., Bondt, Albert, Hennig, René, Gardner, Richard A., O'Flaherty, Roisin, Trbojević-Akmačić, Irena, Shubhakar, Archana, Hazes, Johanna M.W., Reichl, Udo, Fernandes, Daryl L., Pučić-Baković, Maja, Rapp, Erdmann, Spencer, Daniel I.R., Dolhain, Radboud J.E.M., Rudd, Pauline M., Lauc, Gordan, Wuhrer, Manfred

“…N-Glycosylation is a fundamentally important protein modification with a major impact on glycoprotein characteristics such as serum half-life and receptor…”
Get full text

High-Throughput Analysis and Automation for Glycomics Studies by Shubhakar, Archana, Reiding, Karli R, Gardner, Richard A, Spencer, Daniel I. R, Fernandes, Daryl L, Wuhrer, Manfred

“…This review covers advances in analytical technologies for high-throughput (HTP) glycomics. Our focus is on structural studies of glycoprotein glycosylation to…”
Get full text

Protein O-glycosylation analysis by Zauner, Gerhild, Kozak, Radoslaw P, Gardner, Richard A, Fernandes, Daryl L, Deelder, André M, Wuhrer, Manfred

“…This review provides an overview on the methods available for analysis of O-glycosylation. Three major themes are addressed: analysis of released O-glycans…”
Get more information

Suppression of peeling during the release of O-glycans by hydrazinolysis by Kozak, Radoslaw P., Royle, Louise, Gardner, Richard A., Fernandes, Daryl L., Wuhrer, Manfred

“…The analysis of O-glycans is essential for better understanding their functions in biological processes. Although many techniques for O-glycan release have…”
Get full text

Variation of Human Salivary O-Glycome by Kozak, Radoslaw P, Urbanowicz, Paulina A, Punyadeera, Chamindie, Reiding, Karli R, Jansen, Bas C, Royle, Louise, Spencer, Daniel I, Fernandes, Daryl L, Wuhrer, Manfred

“…The study of saliva O-glycosylation is receiving increasing attention due to the potential of glycans for disease biomarkers, but also due to easy access and…”
Get full text

Longitudinal monitoring of immunoglobulin A glycosylation during pregnancy by simultaneous MALDI-FTICR-MS analysis of N- and O-glycopeptides by Bondt, Albert, Nicolardi, Simone, Jansen, Bas C., Stavenhagen, Kathrin, Blank, Dennis, Kammeijer, Guinevere S. M., Kozak, Radoslaw P., Fernandes, Daryl L., Hensbergen, Paul J., Hazes, Johanna M. W., van der Burgt, Yuri E. M., Dolhain, Radboud J. E. M., Wuhrer, Manfred

“…Immunoglobulin A (IgA) is a glycoprotein of which altered glycosylation has been associated with several pathologies. Conventional methods for IgA N - and O…”
Get full text

Correction: changes to serum sample tube and processing methodology does not cause inter-individual variation in automated whole serum N-glycan profiling in health and disease by Ventham, Nicholas T, Gardner, Richard A, Kennedy, Nicholas A, Shubhakar, Archana, Kalla, Rahul, Nimmo, Elaine R, Fernandes, Daryl L, Satsangi, Jack, Spencer, Daniel I R

Get full text

Comparison of procainamide and 2-aminobenzamide labeling for profiling and identification of glycans by liquid chromatography with fluorescence detection coupled to electrospray ionization–mass spectrometry by Kozak, Radoslaw P., Tortosa, Concepcion Badia, Fernandes, Daryl L., Spencer, Daniel I.R.

“…One of the most widely used methods for glycan analysis is fluorescent labeling of released glycans followed by hydrophilic interaction…”
Get full text

Automated High-Throughput Permethylation for Glycosylation Analysis of Biologics Using MALDI-TOF-MS by Shubhakar, Archana, Kozak, Radoslaw P, Reiding, Karli R, Royle, Louise, Spencer, Daniel I. R, Fernandes, Daryl L, Wuhrer, Manfred

“…Monitoring glycoprotein therapeutics for changes in glycosylation throughout the drug’s life cycle is vital, as glycans significantly modulate the stability,…”
Get full text

Mass spectrometry for glycosylation analysis of biopharmaceuticals by Dotz, Viktoria, Haselberg, Rob, Shubhakar, Archana, Kozak, Radoslaw P., Falck, David, Rombouts, Yoann, Reusch, Dietmar, Somsen, Govert W., Fernandes, Daryl L., Wuhrer, Manfred

“…•Biopharmaceuticals are very promising for the treatment of multiple diseases.•Therapeutic proteins often bear sugar chains that can influence their…”
Get full text

Improved nonreductive O-glycan release by hydrazinolysis with ethylenediaminetetraacetic acid addition by Kozak, Radoslaw P., Royle, Louise, Gardner, Richard A., Bondt, Albert, Fernandes, Daryl L., Wuhrer, Manfred

“…The study of protein O-glycosylation is receiving increasing attention in biological, medical, and biopharmaceutical research. Improved techniques are required…”
Get full text

Analysis of Three Epoetin Alpha Products by LC and LC-MS Indicates Differences in Glycosylation Critical Quality Attributes, Including Sialic Acid Content by Thomson, Rebecca I, Gardner, Richard A, Strohfeldt, Katja, Fernandes, Daryl L, Stafford, Graham P, Spencer, Daniel I. R, Osborn, Helen M. I

“…Erythropoietin (EPO) is one of the main therapeutics used to treat anemic patients, greatly improving their quality of life. In this study, biosimilars…”
Get full text

Serum N-Glycomic Biomarkers Predict Treatment Escalation in Inflammatory Bowel Disease by Shubhakar, Archana, Jansen, Bas C, Adams, Alex T, Reiding, Karli R, Ventham, Nicholas T, Kalla, Rahul, Bergemalm, Daniel, Urbanowicz, Paulina A, Gardner, Richard A, Wuhrer, Manfred, Halfvarson, Jonas, Satsangi, Jack, Fernandes, Daryl L, Spencer, Daniel I R

“…Abstract Biomarkers to guide clinical decision making at diagnosis of inflammatory bowel disease [IBD] are urgently needed. We investigated a composite serum…”
Get full text

Towards automation of glycomic profiling of complex biological materials by Shubhakar, Archana, Pang, Poh-Choo, Fernandes, Daryl L., Dell, Anne, Spencer, Daniel I. R., Haslam, Stuart M.

“…Glycosylation is considered one of the most complex and structurally diverse post-translational modifications of proteins. Glycans play important roles in many…”
Get full text

Changes to Serum Sample Tube and Processing Methodology Does Not Cause Inter-Individual Variation in Automated Whole Serum N-Glycan Profiling in Health and Disease by Ventham, Nicholas T., Gardner, Richard A., Kennedy, Nicholas A., Shubhakar, Archana, Kalla, Rahul, Nimmo, Elaine R., Fernandes, Daryl L., Satsangi, Jack, Spencer, Daniel I. R.

“…Introduction Serum N-glycans have been identified as putative biomarkers for numerous diseases. The impact of different serum sample tubes and processing…”
Get full text

Changes to serum sample tube and processing methodology does not cause Intra-Individual [corrected] variation in automated whole serum N-glycan profiling in health and disease by Ventham, Nicholas T, Gardner, Richard A, Kennedy, Nicholas A, Shubhakar, Archana, Kalla, Rahul, Nimmo, Elaine R, Fernandes, Daryl L, Satsangi, Jack, Spencer, Daniel I R

“…Serum N-glycans have been identified as putative biomarkers for numerous diseases. The impact of different serum sample tubes and processing methods on…”
Get full text

Identification of highly fucosylated N‐linked oligosaccharides from the human parotid gland by Guile, Geoffrey R., Harvey, David J., O'Donnell, Niall, Powell, Andrew K., Hunter, Ann P., Zamze, Susanne, Fernandes, Daryl L., Dwek, Raymond A., Wing, David R.

“…The glycosylation of a number of constituents of human saliva is known to modify its biological roles, such as its lubricating properties and binding of…”
Get full text

High-throughput Serum N-Glycomics: Method Comparison and Application to Study Rheumatoid Arthritis and Pregnancy-associated Changes by Reiding, Karli R, Bondt, Albert, Hennig, René, Gardner, Richard A, O'Flaherty, Roisin, Trbojević-Akmačić, Irena, Shubhakar, Archana, Hazes, Johanna M W, Reichl, Udo, Fernandes, Daryl L, Pučić-Baković, Maja, Rapp, Erdmann, Spencer, Daniel I R, Dolhain, Radboud J E M, Rudd, Pauline M, Lauc, Gordan, Wuhrer, Manfred

“…N-Glycosylation is a fundamentally important protein modification with a major impact on glycoprotein characteristics such as serum half-life and receptor…”
Get full text