Search Results - "Darwish, Khaled M"

Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the hACE2 Receptor by Al-Karmalawy, Ahmed A., Dahab, Mohammed A., Metwaly, Ahmed M., Elhady, Sameh S., Elkaeed, Eslam B., Eissa, Ibrahim H., Darwish, Khaled M.

“…The rapid and global spread of a new human coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has produced an immediate urgency to…”
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Calendulaglycoside A showing potential activity against SARS-CoV-2 main protease: Molecular docking, molecular dynamics, and SAR studies by Zaki, Ahmed A., Ashour, Ahmed, Elhady, Sameh S., Darwish, Khaled M., Al-Karmalawy, Ahmed A.

“…Background and aim: The discovery of drugs capable of inhibiting SARS-CoV-2 is a priority for human beings due to the severity of the global health pandemic…”
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Computational and Biological Evaluation of β -Adrenoreceptor Blockers as Promising Bacterial Anti-Virulence Agents by Almalki, Ahmad J, Ibrahim, Tarek S, Elhady, Sameh S, Hegazy, Wael A H, Darwish, Khaled M

“…Bacterial resistance to antibiotics is an increasing public health threat as it has the potential to affect people at any stage of life, as well as veterinary…”
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In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity by Elmaaty, Ayman Abo, Darwish, Khaled M, Chrouda, Amani, Boseila, Amira A, Tantawy, Mohamed A, Elhady, Sameh S, Shaik, Afzal B, Mustafa, Muhamad, Al-Karmalawy, Ahmed A

“…Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated to rise in the next years. On the other hand, vascular endothelial…”
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Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation by Albash, Rofida, Badawi, Noha M, Hamed, Mohammed I A, Ragaie, Maha H, Mohammed, Sahar S, Elbesh, Rovan M, Darwish, Khaled M, Lashkar, Manar O, Elhady, Sameh S, Mosallam, Shaimaa

“…The foremost target of the current work was to formulate and optimize a novel bergamot essential oil (BEO) loaded nano-phytosomes (NPs) and then combine it…”
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Repurposing levocetirizine hydrochloride loaded into cationic ceramide/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization, in- silico and in-vivo studies by Albash, Rofida, El-Dahmy, Rania Moataz, Hamed, Mohammed I. A., Darwish, Khaled M., Alahdal, Abdulrahman M., Kassem, Amira B., Fahmy, Abdurrahman M.

“…Levocetirizine hydrochloride (LVC) is an antihistaminic drug that is repurposed for the treatment of alopecia. This investigation is targeted for formulating…”
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Molecular Docking and Dynamics Simulation Study of Hyrtios erectus Isolated Scalarane Sesterterpenes as Potential SARS-CoV-2 Dual Target Inhibitors by Elhady, Sameh S., Abdelhameed, Reda F. A., Malatani, Rania T., Alahdal, Abdulrahman M., Bogari, Hanin A., Almalki, Ahmad J., Mohammad, Khadijah A., Ahmed, Safwat A., Khedr, Amgad I. M., Darwish, Khaled M.

“…Presently, the world is under the toll of pandemic coronavirus disease-2019 (COVID-19) outbreak caused by SARS-CoV-2. Lack of effective and safe therapeutics…”
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HBD-2 variants and SARS-CoV-2: New insights into inter-individual susceptibility by Behairy, Mohammed Y, Soltan, Mohamed A, Eldeen, Muhammad Alaa, Abdulhakim, Jawaher A, Alnoman, Maryam M, Abdel-Daim, Mohamed M, Otifi, Hassan, Al-Qahtani, Saleh M, Zaki, Mohamed Samir A, Alsharif, Ghadi, Albogami, Sarah, Jafri, Ibrahim, Fayad, Eman, Darwish, Khaled M, Elhady, Sameh S, Eid, Refaat A

“…A deep understanding of the causes of liability to SARS-CoV-2 is essential to develop new diagnostic tests and therapeutics against this serious virus in order…”
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Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations by Fathallah, Noha, Elkady, Wafaa M, Zahran, Sara A, Darwish, Khaled M, Elhady, Sameh S, Elkhawas, Yasmin A

“…Recently, there has been a surge towards searching for primitive treatment strategies to discover novel therapeutic approaches against multi-drug-resistant…”
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Repurposing α -Adrenoreceptor Blockers as Promising Anti-Virulence Agents in Gram-Negative Bacteria by Almalki, Ahmad J, Ibrahim, Tarek S, Elhady, Sameh S, Darwish, Khaled M, Hegazy, Wael A H

“…Antimicrobial resistance is among the world's most urgent public health problems. Diminishing of the virulence of bacteria is a promising approach to decrease…”
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Development of a novel papain gel formulation: Exploring different concentrations for smear-layer deproteinization and enhanced dentin bonding by Kusumasari, Citra, Meidyawati, Ratna, Megantoro, Aryo, Tiara, Rachendra, Meiskya, Agita, Darwish, Khaled M., Abdou, Ahmed

“…The self-etch adhesive system modifies but does not completely remove the smear layer, leading to the weakening of the bond strength due to the formation of a…”
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Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: in silico studies, statistical optimization, ex vivo, and in vivo studies by Albash, Rofida, Fahmy, Abdurrahman M., Hamed, Mohammed I.A., Darwish, Khaled M., El-Dahmy, Rania Moataz

“…Spironolactone (SP) is a potassium sparing diuretic with antiandrogenic properties. This study aimed at formulating SP into hyaluronic acid enriched cerosomes…”
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Mining of Marburg Virus Proteome for Designing an Epitope-Based Vaccine by Soltan, Mohamed A., Abdulsahib, Waleed K., Amer, Mahmoud, Refaat, Ahmed M., Bagalagel, Alaa A., Diri, Reem M., Albogami, Sarah, Fayad, Eman, Eid, Refaat A., Sharaf, Sherin M. A., Elhady, Sameh S., Darwish, Khaled M., Eldeen, Muhammad Alaa

“…Marburg virus (MARV) is one of the most harmful zoonotic viruses with deadly effects on both humans and nonhuman primates. Because of its severe outbreaks with…”
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Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein by Nagy, Manar I, Darwish, Khaled M, Kishk, Safaa M, Tantawy, Mohamed A, Nasr, Ali M, Qushawy, Mona, Swidan, Shady A, Mostafa, Samia M, Salama, Ismail

“…Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition of Bcl-2 for triggered pro-apoptotic signaling…”
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The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme by Malebari, Azizah M., Ibrahim, Tarek S., Salem, Ibrahim M., Salama, Ismail, Khayyat, Ahdab N., Mostafa, Samia M., El-Sabbagh, Osama I., Darwish, Khaled M.

“…The membrane-bound human carbonic anhydrase (hCA) IX is widely recognized as a marker of tumor hypoxia and a prognostic factor within several human cancers…”
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Computational Analysis of Deleterious SNPs in NRAS to Assess Their Potential Correlation With Carcinogenesis by Behairy, Mohammed Y., Soltan, Mohamed A., Adam, Mohamed S., Refaat, Ahmed M., Ezz, Ehab M., Albogami, Sarah, Fayad, Eman, Althobaiti, Fayez, Gouda, Ahmed M., Sileem, Ashraf E., Elfaky, Mahmoud A., Darwish, Khaled M., Alaa Eldeen, Muhammad

“…The NRAS gene is a well-known oncogene that acts as a major player in carcinogenesis. Mutations in the NRAS gene have been linked to multiple types of human…”
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Repurposing of Sitagliptin- Melittin Optimized Nanoformula against SARS-CoV-2: Antiviral Screening and Molecular Docking Studies by Al-Rabia, Mohammed W, Alhakamy, Nabil A, Ahmed, Osama A A, Eljaaly, Khalid, Aloafi, Ahmed L, Mostafa, Ahmed, Asfour, Hani Z, Aldarmahi, Ahmed A, Darwish, Khaled M, Ibrahim, Tarek S, Fahmy, Usama A

“…The outbreak of the COVID-19 pandemic in China has become an urgent health and economic challenge. The objective of the current work was to evaluate the…”
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The Anti-Virulence Activities of the Antihypertensive Drug Propranolol in Light of Its Anti-Quorum Sensing Effects against Pseudomonas aeruginosa and Serratia marcescens by Alotaibi, Hadil Faris, Alotaibi, Haifa, Darwish, Khaled M, Khafagy, El-Sayed, Abu Lila, Amr S, Ali, Mohamed A M, Hegazy, Wael A H, Alshawwa, Samar Zuhair

“…The development of bacterial resistance is an increasing global concern that requires discovering new antibacterial agents and strategies. Bacterial quorum…”
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Integration of Chemoinformatics and Multi-Omics Analysis Defines ECT2 as a Potential Target for Cancer Drug Therapy by Soltan, Mohamed A, Eldeen, Muhammad Alaa, Sajer, Bayan H, Abdelhameed, Reda F A, Al-Salmi, Fawziah A, Fayad, Eman, Jafri, Ibrahim, Ahmed, Hebatallah Emam Mohammed, Eid, Refaat A, Hassan, Hesham M, Al-Shraim, Mubarak, Negm, Amr, Noreldin, Ahmed E, Darwish, Khaled M

“…Epithelial cell transforming 2 (ECT2) is a potential oncogene and a number of recent studies have correlated it with the progression of several human cancers…”
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In Silico Designing of a Multitope Vaccine against Rhizopus microsporus with Potential Activity against Other Mucormycosis Causing Fungi by Soltan, Mohamed A, Eldeen, Muhammad Alaa, Elbassiouny, Nada, Kamel, Hasnaa L, Abdelraheem, Kareem M, El-Gayyed, Hanaa Abd, Gouda, Ahmed M, Sheha, Mohammed F, Fayad, Eman, Ali, Ola A Abu, Ghany, Khalid Abd El, El-Damasy, Dalia A, Darwish, Khaled M, Elhady, Sameh S, Sileem, Ashraf E

“…During the current era of the COVID-19 pandemic, the dissemination of Mucorales has been reported globally, with elevated rates of infection in India, and…”
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