Search Results - "Darwin, K Heran"

Structural determinants of regulated proteolysis in pathogenic bacteria by ClpP and the proteasome by Kahne, Shoshanna C, Darwin, K Heran

“…•As in eukaryotes, chambered proteases are essential for normal physiology in bacteria.•The timing and selection of specific substrates for degradation is…”
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Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis by Pearce, Michael J, Mintseris, Julian, Ferreyra, Jessica, Gygi, Steven P, Darwin, K. Heran

“…The protein modifier ubiquitin is a signal for proteasome-mediated degradation in eukaryotes. Proteasome-bearing prokaryotes have been thought to degrade…”
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Copper in Microbial Pathogenesis: Meddling with the Metal by Samanovic, Marie I., Ding, Chen, Thiele, Dennis J., Darwin, K. Heran

“…Transition metals such as iron, zinc, copper, and manganese are essential for the growth and development of organisms ranging from bacteria to mammals…”
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Bacterial Proteasomes: Mechanistic and Functional Insights by Becker, Samuel H, Darwin, K Heran

“…Regulated proteolysis is essential for the normal physiology of all organisms. While all eukaryotes and archaea use proteasomes for protein degradation, only…”
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Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra by Ji, Daisy X., Yamashiro, Livia H., Chen, Katherine J., Mukaida, Naofumi, Kramnik, Igor, Darwin, K. Heran, Vance, Russell E.

“…The bacterium Mycobacterium tuberculosis (Mtb) causes tuberculosis and is responsible for more human mortality than any other single pathogen 1 . Progression…”
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The mycobacterial proteasomal ATPase Mpa forms a gapped ring to engage the 20S proteasome by Yin, Yanting, Kovach, Amanda, Hsu, Hao-Chi, Darwin, K. Heran, Li, Huilin

“…Although many bacterial species do not possess proteasome systems, the actinobacteria, including the human pathogen Mycobacterium tuberculosis, use proteasome…”
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Proteasome substrate capture and gate opening by the accessory factor PafE from Mycobacterium tuberculosis by Hu, Kuan, Jastrab, Jordan B., Zhang, Susan, Kovach, Amanda, Zhao, Gongpu, Darwin, K. Heran, Li, Huilin

“…In all domains of life, proteasomes are gated, chambered proteases that require opening by activators to facilitate protein degradation. Twelve proteasome…”
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Aldehyde accumulation in Mycobacterium tuberculosis with defective proteasomal degradation results in copper sensitivity by Limón, Gina, Samhadaneh, Nora M, Pironti, Alejandro, Darwin, K Heran

“…is a major human pathogen and the causative agent of tuberculosis disease. is able to persist in the face of host-derived antimicrobial molecules nitric oxide…”
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Proteasomal Control of Cytokinin Synthesis Protects Mycobacterium tuberculosis against Nitric Oxide by Samanovic, Marie I., Tu, Shengjiang, Novák, Ondřej, Iyer, Lakshminarayan M., McAllister, Fiona E., Aravind, L., Gygi, Steven P., Hubbard, Stevan R., Strnad, Miroslav, Darwin, K. Heran

“…One of several roles of the Mycobacterium tuberculosis proteasome is to defend against host-produced nitric oxide (NO), a free radical that can damage numerous…”
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Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation by Darwin, K Heran, Li, Huilin, Wang, Tao

“…The prokaryotic ubiquitin-like protein Pup is involved in the Mycobacterium tuberculosis proteasome pathway but is an intrinsically disordered protein, unlike…”
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The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors by Darwin, K Heran, Stanley, Sarah A

“…There are many reactive intermediates found in metabolic pathways. Could these potentially toxic molecules be exploited for an organism's benefit? We propose…”
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Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons by Ji, Daisy X, Witt, Kristen C, Kotov, Dmitri I, Margolis, Shally R, Louie, Alexander, Chevée, Victoria, Chen, Katherine J, Gaidt, Moritz M, Dhaliwal, Harmandeep S, Lee, Angus Y, Nishimura, Stephen L, Zamboni, Dario S, Kramnik, Igor, Portnoy, Daniel A, Darwin, K Heran, Vance, Russell E

“…Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important…”
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The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control pathway by Becker, Samuel H., Jastrab, Jordan B., Dhabaria, Avantika, Chaton, Catherine T., Rush, Jeffrey S., Korotkov, Konstantin V., Ueberheide, Beatrix, Darwin, K. Heran

“…The human pathogen Mycobacterium tuberculosis encodes a proteasome that carries out regulated degradation of bacterial proteins. It has been proposed that the…”
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A novel copper‐responsive regulon in Mycobacterium tuberculosis by Festa, Richard A., Jones, Marcus B., Butler‐Wu, Susan, Sinsimer, Daniel, Gerads, Russell, Bishai, William R., Peterson, Scott N., Darwin, K. Heran

“…Summary In this work we describe the identification of a copper‐inducible regulon in Mycobacterium tuberculosis (Mtb). Among the regulated genes was…”
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Mycobacterium tuberculosis proteasomal ATPase Mpa has a β‐grasp domain that hinders docking with the proteasome core protease by Wu, Yujie, Hu, Kuan, Li, Defeng, Bai, Lin, Yang, Shaoqing, Jastrab, Jordan B., Xiao, Shuhao, Hu, Yonglin, Zhang, Susan, Darwin, K. Heran, Wang, Tao, Li, Huilin

“…Summary Mycobacterium tuberculosis (Mtb) has a proteasome system that is essential for its ability to cause lethal infections in mice. A key component of the…”
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Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone by Becker, Samuel H., Ulrich, Kathrin, Dhabaria, Avantika, Ueberheide, Beatrix, Beavers, William, Skaar, Eric P., Iyer, Lakshminarayan M., Aravind, L., Jakob, Ursula, Darwin, K. Heran

“…M. tuberculosis infections are responsible for more than 1 million deaths per year. Developing effective strategies to combat this disease requires a greater…”
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Characterization of Guided Entry of Tail-Anchored Proteins 3 Homologues in Mycobacterium tuberculosis by Hu, Kuan, Jordan, Ashley T, Zhang, Susan, Dhabaria, Avantika, Kovach, Amanda, Rangel, Margarita V, Ueberheide, Beatrix, Li, Huilin, Darwin, K Heran

“…We characterized an operon in , Rv3679-Rv3680, in which each open reading frame is annotated to encode "anion transporter ATPase" homologues. Using structure…”
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Prokayrotic Ubiquitin-Like Protein (Pup) Proteome of Mycobacterium tuberculosis by Festa, Richard A, McAllister, Fiona, Pearce, Michael J, Mintseris, Julian, Burns, Kristin E, Gygi, Steven P, Darwin, K. Heran

“…Prokaryotic ubiquitin-like protein (Pup) in Mycobacterium tuberculosis (Mtb) is the first known post-translational small protein modifier in prokaryotes, and…”
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The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence by Shi, Xiaoshan, Festa, Richard A, Ioerger, Thomas R, Butler-Wu, Susan, Sacchettini, James C, Darwin, K Heran, Samanovic, Marie I

“…As with most life on Earth, the transition metal copper (Cu) is essential for the viability of the human pathogen Mycobacterium tuberculosis. However, infected…”
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“Depupylation” of Prokaryotic Ubiquitin-like Protein from Mycobacterial Proteasome Substrates by Burns, Kristin E., Cerda-Maira, Francisca A., Wang, Tao, Li, Huilin, Bishai, William R., Darwin, K. Heran

“…Ubiquitin (Ub) provides the recognition and specificity required to deliver proteins to the eukaryotic proteasome for destruction. Prokaryotic ubiquitin-like…”
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