Search Results - "Dartois, Véronique"

The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells by Dartois, Véronique

“…Understanding the pharmacokinetic and pharmacodynamic properties of anti-tuberculosis drugs is crucial for designing more effective dosing regimens. In this…”
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Therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease by Dartois, Véronique, Dick, Thomas

“…Tuberculosis (TB) drug discovery and development has undergone nothing short of a revolution over the past 20 years. Successful public–private partnerships and…”
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Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters by Sarathy, Jansy P, Dartois, Véronique

“…Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-recalcitrant persisting mycobacteria. Caseum is found in closed nodules…”
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Drug development challenges in nontuberculous mycobacterial lung disease: TB to the rescue by Dartois, Véronique, Dick, Thomas

“…Nontuberculous mycobacterial pulmonary disease (NTM-PD) is treated with multiple repurposed drugs. Chemotherapy is long and often toxic, includes parenteral…”
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Visualization of Mycobacterial Biomarkers and Tuberculosis Drugs in Infected Tissue by MALDI-MS Imaging by Blanc, Landry, Lenaerts, Anne, Dartois, Véronique, Prideaux, Brendan

“…MALDI mass-spectrometry imaging (MALDI-MSI) is a technique capable of the label-free identification and visualization of analytes in tissue sections. We have…”
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Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses by Lenaerts, Anne, Barry III, Clifton E., Dartois, Véronique

“…Summary Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple types and fates of pulmonary lesions that form following…”
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NTM drug discovery: status, gaps and the way forward by Wu, Mu-Lu, Aziz, Dinah B., Dartois, Véronique, Dick, Thomas

“…•Incidence of lung disease caused by non-TB mycobacteria (NTM) is increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug…”
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A Ginger Root or Plum Model for the Tuberculosis "Granuloma"? by Dartois, Véronique, Dick, Thomas

“…Many tuberculosis (TB) researchers tend to view lung lesions as largely spherical "granulomas" and cavities as granulomas that have become necrotic, expand,…”
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Shortening Tuberculosis Treatment — A Strategic Retreat by Dartois, Véronique, Rubin, Eric J.

“…Our current treatment regimen for tuberculosis, which goes by the somewhat ironic name of “directly observed therapy, short course,” is anything but short…”
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Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties by Negatu, Dereje Abate, Gengenbacher, Martin, Dartois, Véronique, Dick, Thomas

“…Most antibiotics are produced by soil microbes and typically interfere with macromolecular synthesis processes as their antibacterial mechanism of action…”
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Imaging and spatially resolved quantification of drug distribution in tissues by mass spectrometry by Prideaux, Brendan, Lenaerts, Anne, Dartois, Véronique

“…•An overview of recent advances in MSI for drug localization is presented.•MSI provides label-free imaging of drugs and metabolites at high lateral…”
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Reduced Drug Uptake in Phenotypically Resistant Nutrient-Starved Nonreplicating Mycobacterium tuberculosis by SARATHY, Jansy, DARTOIS, Veronique, DICK, Thomas, GENGENBACHER, Martin

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Critical discussion on drug efflux in Mycobacterium tuberculosis by Remm, Sille, Earp, Jennifer C, Dick, Thomas, Dartois, Véronique, Seeger, Markus A

“…Abstract Mycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important goal of tuberculosis research is to shorten the treatment…”
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Rifabutin Is Active against Mycobacterium abscessus in Mice by Dick, Thomas, Shin, Sung Jae, Koh, Won-Jung, Dartois, Véronique, Gengenbacher, Martin

“…There is no reliable cure for lung disease. Rifampin is not used clinically due to poor potency. In contrast, we have shown that rifabutin, another approved…”
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High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions by Prideaux, Brendan, Dartois, Véronique, Staab, Dieter, Weiner, Danielle M, Goh, Anne, Via, Laura E, Barry, Clifton E, Stoeckli, Markus

“…MALDI-MSI is a powerful technology for localizing drug and metabolite distributions in biological tissues. To enhance our understanding of tuberculosis (TB)…”
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Rifampicin has no role in treatment of Mycobacterium avium complex pulmonary disease and bactericidal sterilising drugs are needed: a viewpoint by van Ingen, Jakko, Hoefsloot, Wouter, Dartois, Véronique, Dick, Thomas

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The spectrum of latent tuberculosis: rethinking the biology and intervention strategies by Young, Douglas, Barry, Clifton E, Boshoff, Helena I, Dartois, Véronique, Dick, Thomas, Ehrt, Sabine, Flynn, JoAnne, Schnappinger, Dirk, Wilkinson, Robert J

“…Key Points Latent tuberculosis is defined by the presence of an antigen-specific T cell response in the absence of clinical symptoms. It includes conditions…”
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Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization by Strydom, Natasha, Gupta, Sneha V, Fox, William S, Via, Laura E, Bang, Hyeeun, Lee, Myungsun, Eum, Seokyong, Shim, TaeSun, Barry, 3rd, Clifton E, Zimmerman, Matthew, Dartois, Véronique, Savic, Radojka M

“…The sites of mycobacterial infection in the lungs of tuberculosis (TB) patients have complex structures and poor vascularization, which obstructs drug…”
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Rifabutin Is Active against Mycobacterium abscessus Complex by Aziz, Dinah Binte, Low, Jian Liang, Wu, Mu-Lu, Gengenbacher, Martin, Teo, Jeanette W P, Dartois, Véronique, Dick, Thomas

“…Lung infections caused by are emerging as a global threat to individuals with cystic fibrosis and to other patient groups. Recent evidence for human-to-human…”
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CinA mediates multidrug tolerance in Mycobacterium tuberculosis by Kreutzfeldt, Kaj M., Jansen, Robert S., Hartman, Travis E., Gouzy, Alexandre, Wang, Ruojun, Krieger, Inna V., Zimmerman, Matthew D., Gengenbacher, Martin, Sarathy, Jansy P., Xie, Min, Dartois, Véronique, Sacchettini, James C., Rhee, Kyu Y., Schnappinger, Dirk, Ehrt, Sabine

“…The ability of Mycobacterium tuberculosis ( Mtb ) to resist and tolerate antibiotics complicates the development of improved tuberculosis (TB) chemotherapies…”
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